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Acirax (Acyclovir)
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Acirax

Acirax is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis. Acirax is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old.

Other names for this medication:
Accrivir, Aciherpin, Acirax, Acivir, Acloriv, Aclovir, Acvirall, Acycloguanosine, Acyclor, Acylab, Axovir, Cloviderm, Cutivir, Cycloex, Cyclopiz, Docvir, Herperax, Herpex, Herporax, Herzovir, Kayvir, Lovir, Lyrovir, Nisivir, Ocurax, Okavir, Ophtrhovir, Oveer, Psyvir, Rivol, Rovir, Rowapil, Spaclovir, Trikase, Virclo, Virex, Viroderm, Viroxit, Vivorax, Zoylex

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Also known as: Acyclovir

Description

Acirax (acyclovir) is an antiviral drug. Acyclovir slows the growth and spread of the herpes virus in the body.

Acirax is used to treat infections caused by herpes viruses, such as genital herpes, cold sores, shingles, and chickenpox.

Acirax will not cure herpes, but it can lessen the symptoms of the infection.

Dosage

Patient information about the treatment of herpes, chickenpox, or shingles is available with this medicine. Read it carefully before using this medicine.

Acyclovir is best used as soon as possible after the symptoms of herpes infection or shingles (for example, pain, burning, blisters) begin to appear.

If you are taking acyclovir for the treatment of chickenpox, it is best to start taking acyclovir as soon as possible after the first sign of the chickenpox rash, usually within one day.

Acyclovir capsules, tablets, and oral suspension may be taken with meals or on an empty stomach.

Acyclovir is best taken with a full glass (8 ounces) of water.

If you are using acyclovir oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your herpes infection, chickenpox, or shingles, keep taking acyclovir for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses. However, do not use this medicine more often or for a longer time than your doctor ordered.

If you are taking acyclovir capsules, tablets, or oral suspension, you should drink plenty of water to avoid becoming dehydrated.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules, oral suspension, or tablets): For treatment of genital herpes: Adults and children 12 years of age and older—200 milligrams (mg) five times a day for ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For prevention of recurrent outbreaks of genital herpes infections: Adults and children 12 years of age and older—200 to 400 mg two to five times a day for five days or up to twelve months, depending on how often your outbreaks of infection occur. Children up to 12 years of age—Use and dose must be determined by the doctor. For treatment of chickenpox: Adults and children who weigh over 88 pounds (40 kilograms)—800 mg four times a day for five days. Children 2 years of age and older and weighing 88 pounds (40 kilograms) or less—Dose is based on body weight and must be determined by the doctor. The usual dose is 20 mg per kilogram (kg) of body weight, up to 800 mg, four times a day for five days. Children up to 2 years of age—Use and dose must be determined by the doctor. For treatment of shingles: Adults and children 12 years of age and older—800 mg five times a day for seven to ten days. Children up to 12 years of age—Use and dose must be determined by the doctor. For injection dosage form: For treatment of herpes of the brain, genitals, or mucous membranes, or for the treatment of shingles: Adults and children 12 years of age and older—Dose is based on body weight and must be determined by the doctor. The usual dose is 5 to 10 mg of acyclovir per kg (2.3 to 4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days. Children up to 12 years of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg to 20 mg of acyclovir per kg (4.5 mg to 9.1 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for seven to ten days. For treatment of widespread herpes virus infection in newborns: Infants from birth to 3 months of age—Dose is based on body weight and must be determined by the doctor. The usual dose is 10 mg of acyclovir per kg (4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period and repeated every eight hours for ten days.

Overdose

An overdose of Acirax Topical is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Storage

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acirax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Acirax if you are allergic to acyclovir or valacyclovir (Valtrex).

To make sure Acirax is safe for you, tell your doctor if you have:

kidney disease; or a weak immune system (caused by disease or by using certain medicine).

Tell your doctor if you are pregnant or breastfeeding.

Herpes can be passed to your baby during childbirth if you have a genital lesion when your baby is born. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy. Take your medicine as directed to best control your infection.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Acirax should not be given to a child younger than 2 years old.

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The integration of newly developed technologies will provide new insights and highlight the value of natural products for use as biological probes and new drug candidates. Thus, the predominant forms of 6-methoxysalicylamides will be very different in the aqueous and organic phases. Poor metabolizers were more anxiety-prone and less successfully socialized than extensive metabolizers of debrisoquine. Relationship of C5a receptor modulation to the functional responsiveness of human polymorphonuclear leukocytes to C5a. On the latter view, the sensory/functional dimension provides the fundamental organizing principle of the semantic system.

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Based on these findings, we suggest modifications for future versions of these guidelines that may increase their usefulness to managed care settings. Replacement of the counter ions with ionic detergents dramatically alters the solubility properties of the molecule. FADD/Mort1 is a Fas-associated protein that is thought to mediate apoptosis by recruiting the protease caspase-8. Five-fold deuterated analogues of both enantiomers were used as internal standard. Here, we explore a de novo sequencing strategy in which we combine Lys-N protein digestion with differential isotopic dimethyl labeling to facilitate the (de novo) identification of multiply charged peptides in ESI-MS, both under CID and ETD conditions. Replication of human immunodeficiency virus type 1 (HIV-1) is regulated by a host transcription factor, nuclear factor kappaB (NF-kappaB). In cocultures with osteoblasts and spleen cells from IFN-gamma receptor type II-deficient mice, IL-18 was found to inhibit OCL formation, indicating that IL-18 acted independently of IFN-gamma production: IFN-gamma had no effect in these cocultures. The expression levels of NK group 2, member D (NKG2D), CD107a and FasL on cell surface and cytotoxic ability of miRNAs transfected NKL cells against SMMC-7721 cells were evaluated. 3 restructures agencies that investigate fraud in federal health care programs, Part 1. Exofacial epitope-tagged glucose transporter chimeras reveal COOH-terminal sequences governing cellular localization.

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The gas-chromatography on the volatile oils of the plants belonging to Asiasarum and Asarum genera. New evidence suggests that there may be a genetic predisposition linked to the HLA-A1 antigen. The myocardial formation of reactive oxygen species and mtDNA mutations was enhanced in zidovudine and zalcitabine treated animals. A transcriptional network classifier was inferred from the molecular profiles of 111 human lung carcinomas. We have taken two different approaches to study the cellular events involved in nasal polyposis. Cyathostomins are considered to be the primary helminth pathogen of horses and macrocyclic lactones (ML) are the most frequently used anthelmintics.

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