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Aclene (Adapalene)

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Aclene is a topical retinoid with FDA approval for the treatment of acne vulgaris. Clinicians use retinoids are used to treat a wide variety of skin disorders. Aclene also has multiple off-label therapeutic applications.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Valtrex, Anafranil, Arava, Moduretic, Maxalt, Avapro, Colospa, Etinact, Rosalox, Neurontin, Oxitine, Spaclovir,

Also known as: Adapalene


Aclene is a third-generation topical retinoid primarily used in the treatment of acne. Aclene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Aclene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Aclene works under the skin surface to unclog pores and clear up pimples. Aclene is also known as Adapalene, Adapen, Adaferin. Generic name of Aclene is Adapalene.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


If you overdose Aclene and you don't feel good you should visit your doctor or health care provider immediately.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aclene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Aclene if you are allergic to Aclene components. It is not known whether Aclene will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Aclene in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Aclene, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Aclene. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Aclene suddenly.

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Effect of diethylstilbestrol and steroid hormones on glutaminase activity in the mitochondrial fraction of rat brain. Self-assembled heterogeneous argon/neon core-shell clusters studied by photoelectron spectroscopy. Suppressed mice, however, contain control numbers of B cells expressing genes of the S107VH family and producing VHT15 after mitogenic stimulation. In this study, we engineered a three-dimensional (3D) tissue with a neuronal network that can be easily manipulated and transplanted onto the host brain tissue in vivo. Three different tissue models-pure porcine (porcine graft fixed in porcine tibia, group 1), combination (human hamstring graft and porcine tibia, group 2), and pure human (human graft and tibia, group 3)-were compared using both cyclic-loading and subsequent single-cycle load-to-failure tests to assess the effect of graft and bone tissue source (porcine vs human) on the fixation strength of anterior cruciate ligament reconstruction. Exon skipping and gene transfer restore dystrophin expression in hiPSC-cardiomyocytes harbouring DMD mutations. A retrospective analysis to assess the prognostic and predictive clinical value of breast tumor ErbB-2 receptor expression quantified by enzyme immunoassay (EIA), to compare levels measured by EIA with ErbB-2 status determined by immunohistochemistry (IHC), and to correlate receptor content with levels of phosphorylated (Y1248-P) ErbB-2, a measure of functional tyrosine kinase activity. Solution NMR studies of colicin E1 C-terminal thermolytic peptide.

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The results demonstrate that AR expression in the primordial male reproductive system is highly specific to time and cell type and modify previous understanding on the timing of AR expression in the testicular tissue. pleuropneumoniae) apxIIC gene mutant, HB04C(-), which conferred protection to mice against infection with A. We therefore consider topical CSA to be a safe and effective alternative to topical steroids for treating nummular infiltrates after AK. Maximum mouth opening and occlusion were also evaluated and compared before and after operation. An investigation into spin structures of poly(m-phenylenecarbene), a prototype of magnetic organic molecules, is presented using the ab initio density matrix renormalization group method. Childhood maltreatment was also positively associated with ratings of disorganized/unresolved adult attachment style and negatively associated with ratings of secure adult attachment style. Promising results in the treatment of non-small cell lung cancer (NSCLC) have been seen with agents targeting immune checkpoints, such as programmed cell death 1 (PD-1) or programmed death ligand-1 (PD-L1). In symptomatic HRPC, treatment with prednisone or flutamide leads to similar rates of TTP and overall survival and no difference in subjective or biochemical response. Retrospective analysis of referral patterns, waiting times, treatment with clinical and histological diagnosis, including complications of 600 patients referred to a practice-based oral surgical referral service. This is further evidence to support the use of trypsinogen-2 and trypsin-2-alpha1-antitrypsin for the evaluation of patients suspected of having acute pancreatitis.

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Three genes-filensin, inwardly rectifying potassium channel (IRPC), and pigment epithelium-derived factor (PEDF) were strongly downregulated (by 41.3-, 6.8-, and 5.9-fold, respectively) in senile cataract. Role of mutations in dihydrofolate reductase DfrA (Rv2763c) and thymidylate synthase ThyA (Rv2764c) in Mycobacterium tuberculosis drug resistance. Analysis of affinity-purified preparations by polyacrylamide gel electrophoresis revealed a protein of ca. We therefore recommend systematically placing dental implants during the initial surgery, unless large soft tissue resection preventing adequate swallowing is required. The objective of the current study was to characterize the systemic and local innate immune response of dairy cows to IMI with Mycoplasma bovis, a pathogen of growing concern to the dairy industry. We recruited 487 children, followed up from the pregnancy to the 6th year of life.

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Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan. We recorded the calls of geographically distant pairs of populations in Hungary, with each pair consisting of a forest population and a nearby reed bed population. Evaluation of glycemia as a prognostic method in cranial injuries. Thirty-six Canadian physicians made judgments and decisions regarding 32 hypothetical cardiac patients, each described on 5 characteristics (gender, age, type of cardiovascular procedure, presence/absence of musculoskeletal pain, and degree of motivation) and then completed the 19 items of the Attitude towards Cardiac Rehabilitation Referral scale. The iliac angle varies with the axial level, with the widest angle at the most superior level.

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To help understand control of CT and TCP in El Tor vibrios, we monitored ctxAB and ToxR-dependent toxT transcription by time course primer extension assays. Two separate nested case-control analyses estimated the risk of first-time chronic and paroxysmal AF among users of SAIDs and NSAIDs. Clinical conference: on nursing care of a patient with poor prognosis. If cranial hypertension persists the visual field depression gradually spreads toward the center. A phantom with a bone-like structure covered by a tissue-mimicking material was used to simulate a total hip arthroplasty case. The clinical relevance of oral contraceptive pill-induced plasma lipid changes: facts and fiction. To test this idea, we examined variation in intron size and recombination rate across the genome of the nematode Caenorhabditis elegans. In one of these two cases, coverage of the amputated stump by a free gracilis muscle flap made it possible to minimize the level of amputation and to wear a functional prosthesis. Moreover, correlations between MEPdia amplitude and spontaneous contralateral diaphragmatic activity were observed.

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To provide a systematic overview of the policy and practice literature concerned with the primary healthcare needs of prisoners in England and Wales and to address the implications of these health needs for nurses working in prisons. A case of Newcastle disease virus infection in a female laboratory technician is reported for the first time in Malaysia. Knowledge of the etiopathogenesis of this disease is rapidly improving. Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Multi-unit recordings were performed in awake, socially reared zebra finches, 30 and 60 days of age. The aim of this study is to clarify the difference of DNMT1 expression between lung cancer tissues and corresponding normal lung tissues, to analyze the relationships between DNMT1 expression and clinicopathologic characteristics of lung squamous cell carcinoma and adenocarcinoma, and to investigate the correlation between the expressions of DNMT1 and beta-catenin. We examined the effects of Thrombospondin-2 (TSP2) deficiency on assembly of collagenous extracellular matrix (ECM) by primary marrow-derived mesenchymal stromal cells (MSC) undergoing osteoblast differentiation in culture. These results indicate that Ser-985 phosphorylation of c-Met is bi-directionally regulated through PKC and PP2A, and the Ser-985 phosphorylation status may provide a unique mechanism that confers cellular responsiveness/unresponsivenss to HGF, depending on extracellular conditions. In these situations, the most broadly used multimetric indices can be used to assess the overall damage to the invertebrate community and, thus, the overall anthropogenic pressure, but they do not allow to understand the specific causal effects.

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Using an evaluation model to generate questions for ET nurse education. An expanded Timeline Followback (TLFB) interview and life-events assessment were completed after the IVR SM interval and covered the same time period. If there is a bystander effect the quantity of irradiated cells may be three order less than the bystander cells that affirms the great capacity of stress-signalization system. This study aimed to examine the physical and physiological demands of basketball refereeing. We have found that betaIII is absent from these cells and that beta1 and betaIV are present in microtubules throughout the cytosol.

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Future of regional nursing education: with special reference to regional clinical education in nursing. Traditional pathologic evaluation, however, plays a major role in these advances and serves an equally critical role to aid in determining optimal therapy. Distinct species specific differences were noted in Lex and N-acetyllactosamine staining patterns in rabbit and human corneal epithelia. Here, we investigated whether orientation is a special case or if this phenomenon generalizes to working memory traces of other visual features. Bone structures were, however, better visualized by multiplanar CT due to superior contrast and spatial resolution particularly in the most lateral and medial parts of the joint, indicating superiority of CT for depicting subtle bony TMJ abnormalities in patients with rheumatic disease. It is an indirect measure of dry eye induced inflammation on the ocular surface. This study showed that occlusion is a therapy, which realises normalisation of hyperproliferative skin disorders.

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A number of proteins in Eimeria tenella are shown to possess a carbohydrate similar to that found on the carboxyl terminus of the variant surface glycoprotein from Trypanosoma brucei. It has many risk factors such as age, race, sex, intraocular pressure, optic nerve changes, corneal thickness, refractive error, systemic diseases, family history and trauma. Prospective hospital-based cohort of HIV-infected patients from 2004 to 2012. A rhabdomyosarcoma cell line, RH30, which expresses noroxin generic name high levels of IGFII and contains mutated p53, was also used in these studies. Individuals and populations: the role of long-term, individual-based studies of animals in ecology and evolutionary biology. Once in position, the lead was screwed into the myocardium, the SafeSheath was peeled off, and the lead connected to the generator.

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Improvement of prognostic of high risk pregnancies has allowed diminution of maternal mortality. Collectively, the preceding in vitro and the current in vivo studies suggest that BMD188 and its analogs may find clinical applications in the treatment of prostate cancer patients by inducing apoptotic death of prostate cancer cells. This paper presents a theory describing totally incoherent multiple scattering of turbid spherical samples. This study is limited by its retrospective design, potentially limiting the accuracy of chemotherapy-induced diarrhea grade reporting. Pharmacokinetic profile of a new matrix-type transdermal delivery system: diclofenac diethyl ammonium patch. With attention to the experiences, agency, and rights of tuberculosis (TB) patients, this symposium on TB and ethics brings together a range of different voices from the social sciences and humanities. This noroxin generic overview summarizes the mechanisms of regulation of collagen gene expression in fibroblasts as exemplified by cytokine modulation. Rosiglitazone treatment of diabetes mellitus after solid organ transplantation. The aim of our study was to determine whether Rot has the ability to regulate autolysis.

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Catch me if you scan: ultrasound diagnosis of ectopic pregnancy. No bacterium that we examined needed more than 2 micrograms/ml of PD127,391 for inhibition. Although biological functions of CXCL12 are exerted in part through activation of the small GTPase Rac, the pathway leading from its receptor CXC chemokine receptor (CXCR)4 to Rac activation remains to be determined. Survey of the services implemented by nurses in outpatient clinics and wards. It is hypothesised that consuming food either in multiple small bite sizes or with a longer durations of oral processing may evoke substantial oral processing per gram consumed and an increase in transit time in the oral cavity. The assessment of disease aggressivity in stage D2 prostate cancer patients (review). The experience of smoother smoke is likely to produce some level of belief in reduced harm, regardless of how brands are labelled and whether or not Federal Trade Commission FTC/International Organisation for Standardisation tar, nicotine and carbon monoxide yield figures are used. Rapid access to azepine-fused oxetanols from alkoxy-substituted maleimides.

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