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Acupain (Tramadol)

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Acupain is used to help relieve moderate to moderately severe pain. Acupain is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Other names for this medication:
Accupain, Acupain, Adamon, Anatram, Axedol, Bolodol, Bramadol, Cemadol, Cosdol, Dolocet, Esgiypyrin, Formador, Ibudol, Ivydol, Mandol, Mobiya, Moludol, Ondol, Opiran, Pacadon, Relidol, Sayodol, Spasteez, Supridol, Traceta, Traiz, Tramacip, Tramadol, Tramakind, Tramed, Tramoflex, Tramospas, Tranat, Trapidol, Tridol, Trofel, Tryme, Ultraspas, Ultrax, Vegadol, Victadol, Vintram, Zytram

Similar Products:
Dulcolax, Lexapro, Deltasone, Remeron, Celebrex, Addyi, Persantine, Sildigra, Swilax, Barocul, Alprozam, Samprex, Dorolid, Tarol,

Also known as: Tramadol


Acupain (tramadol) is a pain medicine similar to an opioid. It acts in the central nervous system (CNS) to relieve pain.

Acupain is used to treat moderate to severe pain in adults.

The extended-release form of tramadol (Acupain ER) is for around-the-clock treatment of pain. Acupain ER is not for use on an as-needed basis for pain.


Follow the directions on your prescription label and read all medication guides. Never use Acupain ER in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of Acupain ER.

Never share Acupain ER with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other opioid medications when you start taking Acupain ER.

Acupain ER can be taken with or without food, but take it the same way each time.

Swallow the capsule or tablet whole to avoid exposure to a potentially fatal overdose. Do not crush, chew, break, open, or dissolve.

Measure liquid medicine with the supplied syringe or a dose-measuring device (not a kitchen spoon).

Never crush or break a Acupain ER pill to inhale the powder or mix it into a liquid to inject the drug into your vein. This practice has resulted in death.

You may have withdrawal symptoms if you stop using Acupain ER suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover Acupain ER. Just one dose can cause death in someone using it accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, mix the leftover medicine with cat litter or coffee grounds in a sealed plastic bag throw the bag in the trash.

Detailed Acupain ER dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Acupain ER if you are allergic to it, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Acupain ER should not be given to a child younger than 12 years old. Acupain ER should not be given to anyone younger than 18 years old.

Do not give Acupain ER to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Acupain ER. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

Tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use Acupain ER during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using Acupain ER if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Subjects directed left first showed higher afternoon performance. Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Dynamics of morphological changes in glued intestinal anastomosis. Phenolic composition and antioxidant properties of some traditionally used medicinal plants affected by the extraction time and hydrolysis. The active treatment consisted of standard sleep hygiene, stimulus control, and sleep compression strategies as well as education about community resources, stress management, and techniques to reduce patient disruptive behaviors. New guidelines for the resuscitation of newborns confirm that therapeutic hypothermia should be the standard method of treatment offered to neonates with acute perinatal hypoxia.

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Although magnetic resonance (MR) is the most established imaging modality for investigating connectivity in vivo, the recent advent of hybrid positron emission tomography (PET)/MR scanners paved the way for more comprehensive investigation of brain organization and physiology. Computer-assisted navigated cup placement in primary and secondary dysplastic hips. Management of Neovascular Age-related Macular Degeneration: A Review on Landmark Randomized Controlled Trials. Force predicted higher levels of distress on those measures when the perpetrator was not a father figure and lower levels of distress when the abuser was a father figure. We review the epidemiological evidence for an association of drug treatment with Churg-Strauss syndrome, the diverse diagnostic and pathological criteria for this syndrome, and treatment options. The oxidation products of isoprenoid quinones and chromanols formed specifically in the face of singlet oxygen, can be indicators of singlet oxygen stress. We produced two chimeric IgE antibodies, hIgE-Dp2A and hIgE-Dp2B, directed to two nonoverlapping epitopes (A and B) of the house dust mite allergen Der p 2. Further, we show that this correction can be applied even when the size of the subgroup is unknown until the end of the trial. Hence the family is seldomly borne in mind, in practice as well as in research on early albenza where to buy education.

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The chromosomal distribution of CpG islands in the mouse: evidence for genome scrambling in the rodent lineage. Sphingomyelin activates hepatitis C virus what does adipex pills look like RNA polymerase in a genotype-specific manner. Our experience using different methods to verify the detoxification effect of plasmaexchange (PE). alpina Additionally, the transcript level of FUK is up regulated by nitrogen exhaustion when M. Three of the five patients following the experimental protocol of intraoperative radiotherapy and intraoperative hyperthermia with additional external beam radiotherapy are still alive, which may result in average postoperative survivorship exceeding 15.8 months. Developmental changes in growth factors released by the embryonic inner ear. Among American Indians 45 to 74 years of age, IPH is associated with nonsignificant elevations in total and CVD mortality.

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Changes in environmental humidity zyprexa dosing time affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice. The results presented in this article lead to the conclusion that it would be appropriate to demand control or monitoring of radiation via CT whenever complicated exposure to radiation is required. One hundred patients with a putative diagnosis of PRP and who elected to participate completed a comprehensive survey, followed by acquisition of their medical records, including histopathology slides and reports. Physician-hastened death and end-of-life care: development of a community-wide consensus statement and guidelines. Dermatomyositis as first clinical appearance for a thymic epidermoid cell carcinoma. Non-nociceptive skin mechanoreceptors were activated by puffs of air. Long-term stability of two-jaw surgery for treatment of mandibular deficiency and vertical maxillary excess. N-cadherin expression inhibited neither tyrosine phosphorylation of cellular proteins, GTP uptake onto Ras, nor activation of MAP kinase, suggesting that it does not directly interfere the Ras-MAP kinase pathway.

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The HBe antigen-antibody system and its relationship to clinical and laboratory findings in 100 chronic HBsAg carriers in Great Britain. Balb/c mice were inoculated with live RSV, heat-inactivated RSV or medium. Disruption of spermatogenesis in the liver fluke, Fasciola hepatica by two artemisinin derivatives, artemether and zithromax 250 mg tab artesunate. Neurons capable of NO synthesis have been localized in various thirst-related hypothalamic nuclei. The intervention followed the Steps to Prevent Firearm Injury program of the American Academy of Pediatrics. Penile implant surgery has a high rate of success and a very high patient satisfaction rate. Site-specific insertion mutations in either chvG or chvI abolished tumor formation ability, as well as the ability to grow on complex media. Cranes had significantly higher plasma concentrations than did ducks at 6 hours after injection.

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Resistant strains of non-typeable Haemophilus influenzae (NTHi) are one of the principal causes of recurrent acute otitis media (otitis prone), rhinosinusitis, and pneumonia in young children. Maximal E2 levels as well as clinical and ongoing pregnancy rates were higher in cycle B patients receiving microdose GnRH-a. The purpose of this study was to evaluate the utility of the 12-lead electrocardiogram (ECG) for differentiating paroxysmal narrow QRS complex tachycardias. SB 203580 as the specific inhibitor for p38 MAP kinase activity inhibited TNF-alpha-induced IL-6 production by the parental L cells, indicating that TNF-alpha-activated p38 MAP kinase regulates IL-6 production by the cell lines used in this study. To evaluate our experience with laparoscopic supracervical hysterectomy (LASH) and to assess the short- and medium-term outcome. Finally, polyphenols contribute to the preservation of endothelial integrity by acting on the processes implicated in endothelial proliferation, migration and apoptosis.

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A Dizziness Handicap Inventory evaluating the symptoms of patients was submitted before and after treatment and was evaluated. This study reports the responses of high secondary school students and teachers to a questionnaire on their knowledge and misconceptions about malaria. The results indicate two main points of intervention for preventing VHW attrition. Through a comprehensive literature search for genetic variants of LPL involved in AD association studies, we found four polymorphisms for the current meta-analyses. The maximum density of anopheline mosquitoes that can be permitted in the absence of continuing transmission of filariasis.

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