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Adefin (Nifedipine)
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Adefin

Adefin is a dihydropyridine calcium channel blocker. Adefin is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Adefin was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Adefin works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Adefin, Afeditab, Amarkor, Atanaal, Bresben, Cardifen, Cardiosol, Chronadalate, Conetrin, Cordaflex, Cordilat, Corotrend, Depicor, Fedip, Jutadilat, Lemar, Macorel, Nifatenol, Nifecap, Nifecard, Nifed, Nifedalat, Nifedicor, Nifedin, Nifedipine, Nifedipinum, Nifelat, Nirena, Noviken, Nyefax, Vasdalat, Viscard

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Central nervous system (CNS) infection is a rare complication of endoscopic injection sclerotherapy (EIS) for esophageal varices. Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Good therapeutic outcomes are related to early diagnosis and treatment of osteoporosis before fracture is present. We test those methods on several available algorithms and deduce properties of these algorithms that can be compared with future developments. The technique has also been used widely to identify foreign nucleic acids--for example, bacterial or viral, in host cells. Giving information to the patient and the family is of the utmost importance: risk factors, diagnostic features, things to expect, prognosis, treatment, legal aspects, driving license.

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Incorporation of the test of resistance to antiretroviral drugs in clinical practice. To determine the transport pathway of iron-transferrin complex (Fe-TF) across the marrow-blood barrier, we labeled Fe-TF with colloidal gold and perfused rat femoral marrow with this probe. Network interactions explain effective encoding in the context of medial temporal damage in MCI. Engineering acyl carrier protein to amoxil pediatric dose calculator enhance production of shortened fatty acids. Although the radiation tolerance of the spinal cord is of significant concern in these cases, the chemo- and radiosensitivity of these lesions argues for an aggressive approach where possible. To work effectively with this population, mental health professionals and educators must be alert to what is known about the sexual abuse and exploitation of persons with mental retardation. The best parameters to detect central motor disorders were the central motor conduction time, MEP/M amplitude, T/MEP amplitude and latency ratios, whereas peripheral motor conduction time (PMCT) was best to assess peripheral disorders. Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis.

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Effectiveness of home-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease: a meta-analysis of randomized controlled trials. As a rule, the diagnosis based on anamnestic data, clinical examinations and some functional tests causes no difficulties. Interrelationship of triglycerides with lipoproteins and high-density lipoproteins. We study the interaction of both dense and sparse multiarmed spirals in bistable media modeled by equations of the FitzHugh-Nagumo type. In contrast, SCFSkp2-mediated Cdt1 degradation appears to have arisen relatively recently.

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The average speed measured with a radar speed actos 30 mg generic gun was 44 km/h for all observations. 60th ENMC International Workshop: non X-linked Emery-Dreifuss Muscular Dystrophy 5-7 June 1998, Naarden, The Netherlands. Subjects from the Baltimore Longitudinal Study of Aging (BLSA), consisting of 47 men and 47 women, ages ranging from 30 to 69 years, were compared to subjects from the VA Dental Longitudinal Study (VADLS) in Boston, MA, consisting of 481 men in the same age range. During further diagnostic work-up multiple intraabdominal cystic structures were detected by a computed tomography scan and magnetic resonance imaging. Unilateral vestibular schwannoma in a patient with schwannomatosis in the absence of LZTR1 mutation. Consistent conditional responding was observed, and tests for inclusion of the novel stimuli in the original classes showed class expansion. Administration of F16BP to L-NAME treated rats attenuated the harmful effect of L-NAME. To prevent DSH, more knowledge is needed about its prevalence and associated contextual factors in community samples of adolescents.

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