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Adefin (Nifedipine)

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Adefin is a dihydropyridine calcium channel blocker. Adefin is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Adefin was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Adefin works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Adefin, Afeditab, Amarkor, Atanaal, Bresben, Cardifen, Cardiosol, Chronadalate, Conetrin, Cordaflex, Cordilat, Corotrend, Depicor, Fedip, Jutadilat, Lemar, Macorel, Nifatenol, Nifecap, Nifecard, Nifed, Nifedalat, Nifedicor, Nifedin, Nifedipine, Nifedipinum, Nifelat, Nirena, Noviken, Nyefax, Vasdalat, Viscard

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies have not been performed on the relationship of age to the effects of nifedipine in the pediatric population. Safety and efficacy have not been established.

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Direct determinations of energetic parameters at chitosan/Cr(VI) interfaces by means of immersion heat-conduction microcalorimetry. Correlation between adherence rates measured by MEMS and self-reported questionnaires: a meta-analysis. Eculizumab Dosing Intervals Longer than 17 Days May Be Associated with Greater Risk of Breakthrough Hemolysis in Patients with Paroxysmal Nocturnal Hemoglobinuria. Home nursing as the basis of care of a terminal patient: case study of a patient who was cared for at home until the final moment. Spinal cord compression: investigative how long after drinking alcohol can you take flagyl technics, diagnosis, indications. Internalization of endothelin by cultured human vascular smooth muscle cells: characterization and physiological significance.

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Nurse practitioner role in a chronic congestive heart failure clinic: in-hospital time, costs, and patient satisfaction. The neuroleptic malignant syndrome and its differentiation from lethal catatonia. We hope the proposed model will provide a foothold for introducing the information science and the control theory tools in molecular biology. In ativan 1mg tablet uses in tamil a simulation study, we found that the proposed estimates are more efficient than the unrestricted Kaplan-Meier product limit estimates both with and without censored observations. We investigated the effect of adding N2O to sevoflurane or propofol anesthesia on BIS and SE. Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor.

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The hypoxic extension of replicative life span is ablated by a dominant negative HIF. After delivery PRL, in the context of falling progesterone, stimulates the final induction of milk protein gene expression and lactation. The main aim of this work was to summarise the recent progress in the investigation of the mechanisms of their antitumour action and to discuss their potential. However, the electroacidification pretreatment had a negative impact on the permeate flux and resulted in more significant membrane fouling with correspondingly longer filtration times. The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton. Improved quality of life over one year is associated with improved adherence in patients with schizophrenia. Generally the main objective of acoustic neurinoma (AN) surgery is to totally remove the tumor associated with minimum morbidity. Investigators in the present study explored the effects of hyperbaric oxygen (HBO) therapy on distraction osteogenesis in a rabbit limb-lengthening model. Two patients had premature consolidation of the distraction regenerate but had sufficient tissue for rehabilitation.

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Comparing the two reference methods for ultrasound tissue characterization, reclassification based on chemical/morphometrical analysis resulted in a significant increase in diagnostic accuracy. The instability of antagonist-MR complexes makes them difficult to crystallize. The protein-coelenterazine 2-oxy complex observed in the crystals is photo-active because, in the presence of calcium ion, bioluminescence emission within the crystal is observed. Determination of the purity of valine by isocratic liquid chromatography coupled with charged aerosol detection (CAD). TIH maintains a record of all the commands which affect the appearance of each of medical images such that when a restoration process is required, these image-affect commands can be rapidly identified and transmitted to the user. Total aortic arch replacement for aortic aneurysm in a 91-year-old man: report of a case. Others may present with features of epithelial dedifferentiation in ameloblastoma. For commercial production of therapeutic proteins, CHO cells have been adapted for suspension culture in serum-free media, which is highly beneficial with respect to productivity and economics. Impact of periodontitis on the diabetes-related inflammatory status.

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Central nervous system (CNS) infection is a rare complication of endoscopic injection sclerotherapy (EIS) for esophageal varices. Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients. Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia. Good therapeutic outcomes are related to early diagnosis and treatment of osteoporosis before fracture is present. We test those methods on several available algorithms and deduce properties of these algorithms that can be compared with future developments. The technique has also been used widely to identify foreign nucleic acids--for example, bacterial or viral, in host cells. Giving information to the patient and the family is of the utmost importance: risk factors, diagnostic features, things to expect, prognosis, treatment, legal aspects, driving license.

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Degenerative cervical spondylosis: clinical syndromes, pathogenesis, and management. In the IC, eye position signals showed both multiplicative and additive interactions with auditory responses, whereas in AC the effects were not as well predicted by a gain field model. Low albendazole 400 tablet uses in hindi priced commercial sex workers (CSWs) participated in the Bali STD/AIDS Study, a 3 year educational project evaluating the effect of education on the subsequent use of condoms and the prevalence of STDs and AIDS. Such limitation may promote DA synthesis by (1) reducing primary metabolic activity, thus making available necessary precursors, high energy compounds, and cofactors, and (2) favoring the expression of genes involved in the biosynthesis of this toxin. Using smartphone-based applications (apps) in workplace health promotion: The opinion of German and Austrian leaders. The postnatal development of ocular dominance columns (ODCs) in monkey visual cortex provides an exquisite model for studying mechanisms of experience-guided neuronal plasticity. Our goal was to study metabolic energy stores and lactate content in chronic reversibly and irreversibly dysfunctional myocardium. Structural flexibility of the intestine of Burmese python in response to feeding. There are many reports to describe the variations in the origin, nature of muscle, course of the tendon, and insertion of PM.

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Incorporation of the test of resistance to antiretroviral drugs in clinical practice. To determine the transport pathway of iron-transferrin complex (Fe-TF) across the marrow-blood barrier, we labeled Fe-TF with colloidal gold and perfused rat femoral marrow with this probe. Network interactions explain effective encoding in the context of medial temporal damage in MCI. Engineering acyl carrier protein to amoxil pediatric dose calculator enhance production of shortened fatty acids. Although the radiation tolerance of the spinal cord is of significant concern in these cases, the chemo- and radiosensitivity of these lesions argues for an aggressive approach where possible. To work effectively with this population, mental health professionals and educators must be alert to what is known about the sexual abuse and exploitation of persons with mental retardation. The best parameters to detect central motor disorders were the central motor conduction time, MEP/M amplitude, T/MEP amplitude and latency ratios, whereas peripheral motor conduction time (PMCT) was best to assess peripheral disorders. Mechanisms of action of antiresorptive therapies of postmenopausal osteoporosis.

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Effectiveness of home-based pulmonary rehabilitation for patients with chronic obstructive pulmonary disease: a meta-analysis of randomized controlled trials. As a rule, the diagnosis based on anamnestic data, clinical examinations and some functional tests causes no difficulties. Interrelationship of triglycerides with lipoproteins and high-density lipoproteins. We study the interaction of both dense and sparse multiarmed spirals in bistable media modeled by equations of the FitzHugh-Nagumo type. In contrast, SCFSkp2-mediated Cdt1 degradation appears to have arisen relatively recently.

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The average speed measured with a radar speed actos 30 mg generic gun was 44 km/h for all observations. 60th ENMC International Workshop: non X-linked Emery-Dreifuss Muscular Dystrophy 5-7 June 1998, Naarden, The Netherlands. Subjects from the Baltimore Longitudinal Study of Aging (BLSA), consisting of 47 men and 47 women, ages ranging from 30 to 69 years, were compared to subjects from the VA Dental Longitudinal Study (VADLS) in Boston, MA, consisting of 481 men in the same age range. During further diagnostic work-up multiple intraabdominal cystic structures were detected by a computed tomography scan and magnetic resonance imaging. Unilateral vestibular schwannoma in a patient with schwannomatosis in the absence of LZTR1 mutation. Consistent conditional responding was observed, and tests for inclusion of the novel stimuli in the original classes showed class expansion. Administration of F16BP to L-NAME treated rats attenuated the harmful effect of L-NAME. To prevent DSH, more knowledge is needed about its prevalence and associated contextual factors in community samples of adolescents.

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