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Alphapril (Enalapril)
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Alphapril

Alphapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system. It is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Alphapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that suppresses the renin-angiotensin-aldosterone system to lower blood pressure.

Other names for this medication:
Alphapril, Anapril, Angiotec, Bajaten, Benalapril, Bitensil, Calnate, Cetampril, Corvo, Daren, Defluin, Denapril, Ditensil, Ditensor, Docenala, Ednyt, Ekaril, Enafril, Enaladil, Enalapril, Enalart, Enaldun, Enalek, Enalich, Enalten, Enaprex, Enpril, Feliberal, Gadopril, Herten, Hiperson, Innozide, Insup, Istopril, Lapril, Lenimec, Linatil, Narapril, Ofnifenil, Priltenk, Pulsol, Reminal, Renil, Renitec, Reniten, Sulocten, Tenace, Tencas, Ulticadex

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Also known as: Enalapril

Description

Enalaprilat injection is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Enalaprilat works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. This lowers blood pressure and increases the supply of blood and oxygen to the heart .

This medicine is available only with your doctor's prescription .

Dosage

Usual Adult Dose for Hypertension:

Initial dose: 5 mg orally once a day Maintenance dose: 10 to 40 mg orally per day as a single dose or in 2 divided doses Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses In combination with diuretics: Initial dose: 2.5 mg orally once a day If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2.5 mg orally once a day Maintenance dose: 2.5 to 20 mg daily in 2 divided doses Maximum dose: 40 mg orally per day in 2 divided doses Comments: -Treatment is usually combined with diuretics and digitalis. -Doses should be titrated upward, as tolerated, over a period of a few days or weeks.

Usual Adult Dose for Left Ventricular Dysfunction:

Initial dose: 2.5 mg orally twice a day Maintenance dose: 20 mg orally per day in 2 divided doses Comments: -After the initial dose, the patient should be observed for at least 2 hours and until blood pressure has stabilized for at least an additional hour. -If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension.

Usual Pediatric Dose for Hypertension:

Children 1 month to 17 years: Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response. Maximum dose: Doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients. Comment: -Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 mL/min, as no data are available.

Detailed Alphapril dosage information

Overdose

If you overdose Alphapril and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Alphapril overdosage: fainting, dizziness.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alphapril are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Alphapril if you are allergic to Alphapril components. Be very careful with Alphapril if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Alphapril usage in case of having angioedema, throat, heart disease, diabetes, hands, kidney disease, lower legs, lupus, scleroderma. Be careful with Alphapril usage in case of taking diuretics; aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) as indomethacin (Indocin); potassium supplements; lithium (such as Eskalith, Lithobid). Nimotop can be not safety for elderly people. Avoid dehydration. Be careful with great care in case you want to undergo an operation (dental or any other). Do not use potassium supplements or salt substitutes. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Do not stop taking Alphapril suddenly.

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A proposed mechanism for the role of fermentation in protecting against colonic cancer. A comparison of the staining reactions of the cell walls of Azotobacter chroococcum and those of gram-positive and gram-negative bacteria. Effects of Acupuncture in Anesthesia for Craniotomy: A Meta-Analysis. To get the final product, various conditions in the preparation of sponges were evaluated by in vitro cellular responses and in vivo tissue reactions. Top-down alpha oscillatory network interactions during visuospatial attention orienting. Management steps were: notification of results, referral for colposcopy, biopsy, treatment and follow-up. Our data provide evidence that barriers to access or utilization of contemporary diabetes education confront older patients, minority groups and those with language difficulties. Reduced glutamate decarboxylase activity in rat islet beta cells which survived streptozotocin-induced cytotoxicity.

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Cognitive impairment of vascular origin: neuropathology of cognitive impairment of vascular origin. In one dog an undetected otitis media was signalled by wave-form latency delay. If myocardial perfusion scintigraphy is used for evaluating well trained men, existing normal reference files for semiquantitative evaluation appear to be inadequate. The analysis of complex protein solutions by solubility methods and its application to the proteins of the central nervous system. The patient usually presents with a slowly enlarging asymptomatic swelling, typically without radiographic abnormalities. This paper provides some measurement theory concepts to help judge which is the more appropriate analysis, and also provides parametric confidence limits for Tmax treatment differences.

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Creutzfeldt-Jakob disease in a physician: a review of the disorder in health care workers. The distinguishing features between these neoplasms are discussed. This analysis identified a total of 23 distinct protein spots as the products of at least 11 different Arabidopsis genes. Social planning orientations: exercises in compliance or planned social change?. The evolving picture on the Toll family members in Drosophila contrasts with that of mammalian Toll-like receptors, which are predominantly expressed in immune responsive cells where their activation occurs via microbial structural determinants. The nucleotide sequence of the structural gene of the hemolysin was determined. Larger studies are needed to determine whether these findings are pneumonia-specific and to distinguish organism-specific responses. In this review we provide evidence for the existence of suppressor (Ts) cells and their role in autoimmunity in general and particularly in the system of experimental allergic encephalomyelitis (EAE). Studies on the fine structure of red and white fin muscles of how long can you keep tramadol tablets the fish (Carassius auratus). We evaluated the role of the IL-20R axis in RA and associations between plasma cytokine levels and clinical disease.

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