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Alprine (Alprazolam)
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Alprine

Alprine is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alprine, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alprine is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aderta, Albiz, Alpaz, Alpkair, Alprasan, Alprastan, Alprop, Alzopam, Alzopax, Axizox, Azoslip, Benzax, Depwell, Dizeral, Fledore, Mcalm, Morecalm, Norex, Nucalm, Oclam, Onapract, Pizolam, Pronext, Propnix, Rivcam, Selamb, Serxanti, Stresnil, Tenil, Tranax, Tranisol, Tryzo, Visram, Zedel, Zolam, Zoldac, Zolipax, Zoloid, Zolran, Zoltweet, Zomark

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Indocin, Addyi, Nexium, Dostinex, Biaxin, Glipid, Imipam, Kleromicin, Eritril, Noxaprim, Stomorgyl, Ventiphylline, Clotweet,

Also known as: Alprazolam

Description

Alprine is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alprine is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alprine if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alprine or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alprine. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.

Dosage

Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Alprine dosage information

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprine XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprine XR dosage information

Side effects

The most common side effects associated with Alprine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development. The end-to-end distance variation of the knee ligaments and popliteal complex can be estimated during knee flexion using a robust and reliable method based on marking the ligaments/tendon insertions with radiopaque paint. The successful management of this patient demonstrated that early diagnosis, aggressive surgical and medical treatment and resolution of the underlying disease could improve the prognosis for survival. Combination effect of flutamide and leuprorelin acetate on growth of Dunning R3327-H prostatic adenocarcinoma in rats. Only in Saint Petersburg the application of omeprazole, hiconcil and fromilid in the treatment of adult patients with duodenal ulcer could save up to 26 million rubles per year due to the decrease in the number of recurrences. Dose-dependent reduction of bile secretion in cyclosporine-treated rats.

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For the entire sample, males were significantly more likely to have conduct disorder, and females were significantly more likely to have borderline personality disorder. Considering the embryologic origin and development of the thyroid and parathyroid glands and their descent during embryogenesis into the final position in the neck, a transoral access to the thyroid region via a sublingual mucosal incision seems to be feasible. Evaluation of mutant frequencies at the hprt and the T-cell receptor loci in pediatric cancer patients before treatment. A number of lines of evidence supported this serotonergic hypothesis, not least the treatment studies which demonstrated clearly and consistently that anti-obsessional efficacy was a function of serotonin re-uptake inhibition. The inconclusiveness of such research is commented upon and suggestions for further research are outlined. Conclusions reached were (1) that only data obtained from full limb radiographs are accurate for determining and reporting limb alignment in TKA, (2) that alignment values should be reported relative to the mechanical axis of the limb because of the variability of the femoral anatomic angle, (3) that intramedullary femoral guides are required to make accurate femoral bone cuts, (4) that extramedullary tibial guides permit accurate cuts of the proximal end of the tibia, and (5) that tibial intramedullary guides are not only unnecessary but also potentially misleading.

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We surveyed 570 Fellows of the Royal Australian College of Ophthalmologists to determine what their methods of prophylaxis were and whether these differed for patients who developed endophthalmitis. In the current investigation, we assessed the relationship between PMC and mPFC deactivations and psychopathic personality traits using fMRI and a self-report measure. This article describes how nurseled monitoring works in one clinic, and how it may offer a more holistic type of care. This paper is Part 1 of a five-part series covering practical issues in the performance of decision analysis. The structures entrap and kill insects and therefore are most probably protective. The Effect of Knot Geometry on the Strength of Laparoscopic Slipknots.

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The 24-hourly melatonin estimations for each individual were fitted to a cosine curve, and the significance of the curve fits was calculated. Non-genomic inhibition of human P2X7 purinoceptor by 17beta-oestradiol. In the presence of inhibitors of glucose trimming, the interactions of FVIII with CNX, and of FVIII and FV with CRT, were significantly reduced whereas the secretion of FVIII, and not FV, was inhibited. As TFMPP has a significantly lower affinity for 5-HT1A receptors than 8-OH-DPAT or eltoprazine, the lack of effect of TFMPP supports this view. More Effective Living: a partnership approach to health education programming.

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99mTc-MAG3 clearance can be assessed with acceptable accuracy by a camera-based method. Evaluation of a newborn in a critical state, son of a mother with preeclampsia/eclampsia (pregnancy toxemia). Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations. Available limited studies show that Iranian healthcare personnel need HAV vaccination. This study demonstrated the value of objectively prioritizing MR-associated CNVs using structural and functional genomic features in diagnostics.

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Arterial infusion chemotherapy with SMANCS-Lipiodol for multiple hepatocellular carcinoma. Effect of drinking mineral water on hormonal regulation of glucose homeostasis after mastectomy for breast cancer. In this brief article, some of the recent developments in imaging are reviewed and the ways in which these developments interface with traditional imaging studies are presented. US examination can provide information valuable for the differential diagnosis of a variety of disease processes involving the scrotum that have similar clinical manifestations (eg, pain, swelling, or presence of mass). All in-patients treated at a private psychiatric hospital over a period of 24 months were included in the study. The Tub4p complex is associated with cytoplasmic and nuclear substructures of the SPB, which organize the cytoplasmic and nuclear microtubules.

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We show that Bax activation occurs extremely rapidly, within 15 min after loss of integrin-mediated adhesion to extracellular matrix. A concentration of ouabain that is maximally effective in inhibiting slice potassium accumulation was determined for each species. This case study reviews the history, symptoms, management and rehabilitation of a patient admitted to accident and emergency with severe chest pain. The device comprises a transparent substrate and a thin dielectric surface layer containing sub-micron corrugated structures. We describe the findings in four children with liver transplants in whom occlusion of the graft artery was erroneously suggested by findings on duplex Doppler sonography and angiography. As controls, we assessed the hepatocyte proliferation of liver tissues from 16 patients with chronic hepatitis B and on three normal livers. The orthopantomogram showed a well-circumscribed radiolucent osteolytic image, 1 cm in diameter, on the mandibular angle. Iodide- and phenolic cosubstrate-dependent oxidation of tetracycline to demethylated and dehydrogenated products was also observed, although at a slower rate than MN.

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