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Alprine (Alprazolam)

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Alprine is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alprine, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alprine is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Aderta, Albiz, Alpaz, Alpkair, Alprasan, Alprastan, Alprop, Alzopam, Alzopax, Axizox, Azoslip, Benzax, Depwell, Dizeral, Fledore, Mcalm, Morecalm, Norex, Nucalm, Oclam, Onapract, Pizolam, Pronext, Propnix, Rivcam, Selamb, Serxanti, Stresnil, Tenil, Tranax, Tranisol, Tryzo, Visram, Zedel, Zolam, Zoldac, Zolipax, Zoloid, Zolran, Zoltweet, Zomark

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Indocin, Addyi, Nexium, Dostinex, Biaxin, Glipid, Imipam, Kleromicin, Eritril, Noxaprim, Stomorgyl, Ventiphylline, Clotweet,

Also known as: Alprazolam


Alprine is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Alprine is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Alprine if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Alprine or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Alprine. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day -Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day -Maximum dose: 10 mg/day Extended-release tablets: -Initial dose: 0.5 to 1 mg orally once a day -Maintenance dose: 3 to 6 mg orally per day, preferably in the morning -Maximum dose: 10 mg/day Comments: -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. -The daily dosage may be decreased by no more than 0.5 mg every 3 days; however, some patients may require an even slower dosage reduction. -The dose of extended-release tablets may be increased at intervals of 3 to 4 days in increments of no more than 1 mg per day. -The times of administration should be distributed as evenly as possible throughout the waking hours.

Usual Geriatric Dose for Anxiety:

Elderly or debilitated patients: Immediate-release tablets: 0.25 mg orally administered 2 or 3 times a day.

Usual Geriatric Dose for Panic Disorder:

Elderly or debilitated patients: Immediate-release tablets: -Initial dose: 0.25 mg orally administered 2 or 3 times a day Extended-release tablets: -Initial dose: 0.5 mg orally once a day Comments: -If side effects develop, the dose may be lowered. -The lowest possible effective dose should be administered and the need for continued treatment reassessed frequently. -Dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage.

Detailed Alprine dosage information


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alprine XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alprine XR dosage information

Side effects

The most common side effects associated with Alprine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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Male fertility is declining and an underlying cause may be due to environment-epigenetic interactions in developing sperm, yet nothing is known of how the epigenome controls gene expression in sperm development. The end-to-end distance variation of the knee ligaments and popliteal complex can be estimated during knee flexion using a robust and reliable method based on marking the ligaments/tendon insertions with radiopaque paint. The successful management of this patient demonstrated that early diagnosis, aggressive surgical and medical treatment and resolution of the underlying disease could improve the prognosis for survival. Combination effect of flutamide and leuprorelin acetate on growth of Dunning R3327-H prostatic adenocarcinoma in rats. Only in Saint Petersburg the application of omeprazole, hiconcil and fromilid in the treatment of adult patients with duodenal ulcer could save up to 26 million rubles per year due to the decrease in the number of recurrences. Dose-dependent reduction of bile secretion in cyclosporine-treated rats.

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For the entire sample, males were significantly more likely to have conduct disorder, and females were significantly more likely to have borderline personality disorder. Considering the embryologic origin and development of the thyroid and parathyroid glands and their descent during embryogenesis into the final position in the neck, a transoral access to the thyroid region via a sublingual mucosal incision seems to be feasible. Evaluation of mutant frequencies at the hprt and the T-cell receptor loci in pediatric cancer patients before treatment. A number of lines of evidence supported this serotonergic hypothesis, not least the treatment studies which demonstrated clearly and consistently that anti-obsessional efficacy was a function of serotonin re-uptake inhibition. The inconclusiveness of such research is commented upon and suggestions for further research are outlined. Conclusions reached were (1) that only data obtained from full limb radiographs are accurate for determining and reporting limb alignment in TKA, (2) that alignment values should be reported relative to the mechanical axis of the limb because of the variability of the femoral anatomic angle, (3) that intramedullary femoral guides are required to make accurate femoral bone cuts, (4) that extramedullary tibial guides permit accurate cuts of the proximal end of the tibia, and (5) that tibial intramedullary guides are not only unnecessary but also potentially misleading.

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Proteins interacting with each other as a complex play an important role in many molecular processes and functions. Here we demonstrate that complex limiting behaviour (supercycles and chaotic-like phenomena) may arise in a rather broad and natural class of multilocus systems, both haploid and diploid, experiencing stabilizing selection with cyclically varying optima over a short period. Moreover, we expect that the MAP peptide fusion approach can be extended to other functional tissue-specific motifs. No correlation was demonstrated between lysozyme concentration and total protein level in the cerebrospinal fluid. Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro. MR-guided percutaneous ethanol ablation of liver tissue in a .2-T open MR system: preliminary study in porcine model.

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Based on the study results, penicillin and amoxicillin are suitable antibiotics for treatment of endodontic infection when conventional root canal treatment alone is insufficient. Theoretical investigations on the thermal decomposition mechanism of 5-hydroxy-6-hydroperoxy-5,6-dihydrothymidine in water. The superior transdermal flux of estradiol was due to 1500-fold improvement in solubilization of estradiol by microemulsions. The focus group discussions suggested how to adapt these documentaries to the Nigerian environment and cultural practices. We also summarize the results of our first 46 patients, 24 of which were operated extraperitoneally and 22 by transperitoneal approach with concomitant pelvic surgery. Alteration in the lactate threshold with changes in substrate availability. The patient had endocrine dysfunction consistent with McCune-Albright syndrome. Lung SOT was performed for two patients with BO, kidney transplants for three patients, and liver transplants for three patients (VOD, chronic GVHD). Experience in the use of myodil in the conduct of direct lymphography.

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We surveyed 570 Fellows of the Royal Australian College of Ophthalmologists to determine what their methods of prophylaxis were and whether these differed for patients who developed endophthalmitis. In the current investigation, we assessed the relationship between PMC and mPFC deactivations and psychopathic personality traits using fMRI and a self-report measure. This article describes how nurseled monitoring works in one clinic, and how it may offer a more holistic type of care. This paper is Part 1 of a five-part series covering practical issues in the performance of decision analysis. The structures entrap and kill insects and therefore are most probably protective. The Effect of Knot Geometry on the Strength of Laparoscopic Slipknots.

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Role of DNA in the activation of the Cry1A insecticidal crystal protein from Bacillus thuringiensis. Case 2: A 32-year-old Japanese man, the elder brother of case 1, had a similar clinical history to that of case 1. However, it tended to promote the effects of palmitoylcarnitine on permeation clearance and electric membrane resistance. We consider methodological issues central to the study of neurocognitive functioning and genetic associations for patients with brain tumours, and emphasise the need for future research integrating novel investigative techniques. Instruments designed for pars plana vitrectomy can be used to manage complicated congenital cataracts such as those with persistent hyperplastic primary vitreous (PHPV). Sequence alignment and site-directed mutagenesis confirm the importance of these prolines.

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Increasing competition: ten good suggestions for how to apply for research funds!. Hearing loss is less severe in subjects with the COMT Met allele, possibly due to the protective effect of dopamine on the hearing system. Colostrum-fed, artificially reared piglets obtained from two litters and exposed in the first week of life developed clinical signs of inappetence, vomiting and diarrhoea and shed oocysts in the faeces. Individuals with radiation doses sufficient to cause osteoradionecrosis of the mandible are at significantly higher risk of developing carotid artery atherosclerotic lesions than age-matched, nonirradiated controls. Here, we link the mitochondrial sirtuin SIRT4 with cellular senescence, skin aging, and mitochondrial dysfunction. However, apoptosis induced by both cytotoxic T lymphocytes and natural killer or lymphokine-activated killer cells is not blocked by BCR-ABL. Magnetic resonance angiography of the hand and wrist: evaluation of patients with severe ischemic disease. A Practical Approach to the Evaluation of Gastrointestinal Tract Carcinomas for Lynch Syndrome. This paper discusses various viewpoints regarding the preceptorship process experienced by one post-RN degree nursing program in Western Canada.

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To assess the efficacy of Yizhi capsule (YZC) in treating senile dementia. Asaia (gfp) was introduced in large cages through the release of paratransgenic males or by sugar feeding stations. Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate?. A study of 136 cases of adder bite treated in Swedish hospitals during one year. Oestrogen receptor positivity is associated with improved response to endocrine therapies. Detection and localization of mRNAs encoding matrix metalloproteinases and their tissue inhibitor in human breast pathology. However, this was not the case in a sample of healthy individuals undergoing the same protocol.

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nov., a new alkaliphilic purple sulfur bacterium from a Siberian soda lake. Little changes were observed after 3 weeks treatment with the DMH. We report the isolation and chemical characterization of collagen cross-linking compounds, 3-hydroxypyridinium and dihydroxylysinonorleucine, from human urine. The present results also suggest that following stimulation with PDGF, activation of tyrosine kinase, phospholipase C, phosphatidylinositol 3-kinase, protein kinase C (PKC) and p70 ribosomal protein S6 kinase is essential for the proliferation of adult rat hepatocytes. Expression of SCF mRNA was detected in liver from healthy adult dogs. This study investigated how energy bars of differing macronutrient composition affect postprandial glycemia and insulinemia in normal subjects compared with white bread and chicken breast controls. Measurements were performed with and without their own spherical contact lenses. A key challenge in the SAD phasing method is solving a structure when the anomalous signal-to-noise ratio is low. Analysis of blood serum proteins by the method of immunoelectrophoresis in paraproteinemias. Budd-Chiari syndrome due to prothrombotic disorder: mid-term patency and efficacy of endovascular stents.

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The 24-hourly melatonin estimations for each individual were fitted to a cosine curve, and the significance of the curve fits was calculated. Non-genomic inhibition of human P2X7 purinoceptor by 17beta-oestradiol. In the presence of inhibitors of glucose trimming, the interactions of FVIII with CNX, and of FVIII and FV with CRT, were significantly reduced whereas the secretion of FVIII, and not FV, was inhibited. As TFMPP has a significantly lower affinity for 5-HT1A receptors than 8-OH-DPAT or eltoprazine, the lack of effect of TFMPP supports this view. More Effective Living: a partnership approach to health education programming.

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99mTc-MAG3 clearance can be assessed with acceptable accuracy by a camera-based method. Evaluation of a newborn in a critical state, son of a mother with preeclampsia/eclampsia (pregnancy toxemia). Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations. Available limited studies show that Iranian healthcare personnel need HAV vaccination. This study demonstrated the value of objectively prioritizing MR-associated CNVs using structural and functional genomic features in diagnostics.

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Thermal constraints for range expansion of the invasive green mussel, Perna viridis, in the southeastern United States. Cellular cholesterol efflux is mediated by HDL, acting in conjunction with the cholesterol esterifying enzyme, lecithin: cholesterol acyltransferase. New diagnostic methods, such as serology and polymerase chain reaction, to detect components of the pneumococcal cell wall promise to significantly enhance detection of pneumococci causing childhood pneumonia. Gel retardation experiments indicate that nuclear proteins from tissues in which the ultram gel rab28 gene is expressed can interact specifically with this 134 bp DNA fragment. Antigen presentation by major histocompatibility complex (MHC) class II molecules requires the participation of different proteases in the endocytic route to degrade endocytosed antigens as well as the MHC class II-associated invariant chain (Ii). Significant inhibition was achieved at 20 and 200 microM concentration of hemorphin-7. Further development of a scale indicating the degree of atopic skin diathesis should facilitate the targeting of this counseling toward specific high-risk groups.

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A scale from 1 to 7 was used to rate confidence in prescribing and perception of teratogenic risk. The clinical aspects and diagnostic value of changes in the morphological composition of the peripheral blood in acute methylmercaptophos poisoning. Reflex nature of leukocytosis and of bone marrow reaction to administration of BCG culture. The protection afforded by the two MNAs was long-lasting and no subsequent relapse was observed. In transgenic plants, sarcotoxin IA mRNA accumulated to detectable levels, however, the amount of the peptide produced was so small that we could scarcely detect it by protein gel blot analysis, probably because of the instability of short peptides in plant cells. Building on our initial work describing novel chemoreversal agents (CRAs) that resensitize resistant parasites to chloroquine (CQ), we herein report new hybrid single agents as an innovative strategy in the battle against resistant malaria.

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Male with mosaicism for supernumerary ring X chromosome: analysis of phenotype and characterization of genotype using array comparative genome hybridization. The authors propose the use of a sigmoid tube reimplanted submucosally in the bladder and brought out onto the skin in the midline or in the umbilicus as a method of continent urinary diversion allowing urinary catheterization several times a day when the appendix cannot be used. No such differences were observed in the hippocampus or the cerebral cortex. Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (CREB). Bestatin, a stimulator of polysome assembly in T cell lymphoma (L 5178y). Cats tracked moving targets primarily with small catch-up saccades, and for target speeds of 2-6 degrees /s, they did so with sufficient accuracy to keep targets within 2.5 degrees of the visual axis most of the time. In control cases, serum bile acid reached the maximum level 30 min after loading. The synthesis of pteroyltriglutamate was sufficient for normal cellular retention of folate and also overcame the phenotypic requirement for purines and thymidine of AUXB1, a CHO cell mutant lacking FPGS activity and lacking folylpolyglutamates. Correlated low frequency fluctuations in the blood oxygenation level dependent signal have been widely observed in highly connected brain regions and are considered to be indicative of coordinated activity within those regions. In contrast, thermoregulatory tone is insufficient to prevent core temperature perturbations in patients undergoing vigorous cutaneous cooling or warming.

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Arterial infusion chemotherapy with SMANCS-Lipiodol for multiple hepatocellular carcinoma. Effect of drinking mineral water on hormonal regulation of glucose homeostasis after mastectomy for breast cancer. In this brief article, some of the recent developments in imaging are reviewed and the ways in which these developments interface with traditional imaging studies are presented. US examination can provide information valuable for the differential diagnosis of a variety of disease processes involving the scrotum that have similar clinical manifestations (eg, pain, swelling, or presence of mass). All in-patients treated at a private psychiatric hospital over a period of 24 months were included in the study. The Tub4p complex is associated with cytoplasmic and nuclear substructures of the SPB, which organize the cytoplasmic and nuclear microtubules.

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For male participants, their Sal-T concentrations before each workout was also related to 1RM performance during these exercises, thereby highlighting one possible short-term causative mechanism. General anaesthesia reduces both the production and the stability of tears and therefore increases the incidence of this painful condition. Demographic, surgical, and histopathologic data, including presence of vascular invasion, were reviewed for 106 patients with stage I non-small-cell lung cancer from 1985 through 1990. A draping technique for prevention of coronary bypass graft kinking and suture-line oozing. A striking similarity was observed between the dystrophic temporomandibular joint in patients with juvenile rheumatoid arthritis and micrognathia and the normal radiographic appearance in the first months of life, indicating an early involvement of this joint in patients developing micrognathia. Nontraumatic orbital leptomeningeal cyst in an adult: case report. Thus, the pretrigeminal transection performed at an early period of life improves the development of the caudal part of preparation, but impairs that of the isolated cerebrum.

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As significant feeding into the ERC compartment from the most immature cells is unlikely because of the depletion induced by the Myleran, it may be concluded that highly purified Epo, not contaminated with other biologically active molecules, has a dual effect on the ERC: it causes increased amplification besides inducing differentiation into cells with the capacity to synthesize haemoglobin. Traumatic intracerebral pneumocephalus communicating with two different paranasal sinuses: a case report. Twelve patients were intravenously given a 30 min Bs-MAb infusion (0.1 mg/kg). The binding properties of the two proteins by hyaluronate-substituted Sepharose gel were compared. Inhibition of angiotensin II AT1 receptors protects against stroke, reducing the cerebral blood flow decrease in the periphery of the ischemic lesion. The NEMA image-quality phantom and rodent imaging were also performed to access the overall imaging capabilities of the scanner. Tracheal transplantation and tracheal regeneration may bring major treatment advances to cases with long-segment tracheal involvement.

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Estimation of subcutaneous and visceral adipose tissue and measurement of SAD and transverse abdominal diameter using computed tomography at the umbilical level were obtained in 5,257 men and women who were enrolled in a health checkup program in Korea. Advanced maternal age and perinatal outcome: oocyte recipiency versus natural conception. Also, those infants with NLR are more likely to be born to mothers with chorioamnionitis and they face sepsis and intraventricular hemorrhage more often. Calcium and phosphorus release from the intact enamel of human teeth under various experimental conditions. Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. What effect does electronic ordering have on the organisational dynamics of a hospital pathology service?. This paper is the second case report of this syndrome with omphalocele in the world literature. We speculate that the greater subcutaneous fat deposition in female infants may be related to their better neonatal outcomes. This study shows the importance of alcohol related mortality in our country and the large primidone dosage essential tremor premature death.

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Transformants expressing antisense Gsa showed varying degrees of inhibition resulting in a range of chlorophyll reduction in the seeds. Soybean agglutinin binding as a useful prognostic indicator in stomach cancer. After the first 72 hours, DNA denaturation is massive and does not allow useful cytofluorimetric readings. Requirements for intracellular accumulation and release of clarithromycin and azithromycin by human phagocytes. We conclude that pulse therapy can be used instead of continuous therapy in this rare disease in childhood. Assessment of Reinforced Concrete Surface Breaking Crack Using Rayleigh Wave Measurement. The result is a picture in which the brightness variations represent the reconstructed values of the curl of the velocity field (inverted delta x v). Microarrays were used to obtain expression data on severe cases and uncomplicated controls at the time of acute disease presentation (five uncomplicated and five severe), 1 week after presentation (three uncomplicated and three severe) and treatment initiation, and in the subsequent dry season (late convalescence, four uncomplicated and four severe). Properties such as the cantilever stiffness and resonant frequency, tip shape and sharpness, and material characteristics determine the mode of operation of the AFM and the type of experiments and measurements that can be performed.

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We show that Bax activation occurs extremely rapidly, within 15 min after loss of integrin-mediated adhesion to extracellular matrix. A concentration of ouabain that is maximally effective in inhibiting slice potassium accumulation was determined for each species. This case study reviews the history, symptoms, management and rehabilitation of a patient admitted to accident and emergency with severe chest pain. The device comprises a transparent substrate and a thin dielectric surface layer containing sub-micron corrugated structures. We describe the findings in four children with liver transplants in whom occlusion of the graft artery was erroneously suggested by findings on duplex Doppler sonography and angiography. As controls, we assessed the hepatocyte proliferation of liver tissues from 16 patients with chronic hepatitis B and on three normal livers. The orthopantomogram showed a well-circumscribed radiolucent osteolytic image, 1 cm in diameter, on the mandibular angle. Iodide- and phenolic cosubstrate-dependent oxidation of tetracycline to demethylated and dehydrogenated products was also observed, although at a slower rate than MN.

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