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Alzam (Alprazolam)
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Alzam

Alzam is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alzam, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alzam is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Allam, Alparazole, Alpaz, Alpraday, Alpranex, Alprasert, Alprogard, Alpron, Alprosym, Alprotame, Alzorix, Ambutech, Andep, Anxigo, Axizox, Axnil, Azicalm, Berest, Censir, Dazolam, Depsolam, Depten, Dexolam, Ecsit, Elflu, Fluti, Kurelam, Ozolam, Pizolam, Plxna, Prazolam, Prolam, Pronext, Propnix, Samrox, Selam, Silam, Somaspas, Suzilam, Tenil, Tensyl, Unixl, Xanti, Zeftra, Zepro, Zolax, Zopain, Zopic

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Adalat, Mellaril, Crestor, Ambien, Effexor, Flonase, Cleocin, Coreg, Neurontin, Fosamax, Fertisafe, Goutnil, Repid, Wormicid, Curlzfin, Tetramax, Trichomonacid, Eprotan,

Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alzam XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Alzam XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alzam XR dosage information

Side effects

The most common side effects associated with Alzam are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies have not been performed on the relationship of age to the effects of alprazolam in the pediatric population. Safety and efficacy have not been established.

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Over the past 25 years, studies on the Yersinia effector proteins have unveiled tremendous knowledge of how the effectors enhance Yersinia virulence. The evolving experience of illness for Chinese women with breast cancer: a qualitative study. Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. Use of an embedded, micro-randomised trial to investigate non-compliance in telehealth interventions. A number of multiple regression models, including 21 independent variables, showed no evidence of any intrinsic racial effect on the occurrence of goitre. Increased mural eosinophilic infiltrate had been observed in acute appendicitis. However, it is not known whether this same transformation occurs in patients with chronic heart failure. Electrophoretic mobility shift assay indicated that recombinant mSox7 polypeptide was capable of binding to a nucleotide sequence, AACAAT. Expression of phosphorylated FKHRL1 in T47D cells was analyzed using Western blotting. Development of a Candida glabrata dominant nutritional transformation marker utilizing the Aspergillus nidulans acetamidase gene (amdS).

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Three plasmids were carried in a strain of serovar 2, and single plasmids were detected in strains of serovars 4, 12, and 18. Inhibition phenomena between Salmonella strains--a new aspect of salmonella infection control in poultry. The greatest savings occur in capital equipment acquisition (selection and installation) and maintenance, and result from CE involvement in clinical activities and administrative decision making. The current article reviews the evidence from clinical trials and the recommendations in practice guidelines regarding thrombus aspiration in acute myocardial infarction. This study investigated the influence of gliding arc plasma discharge on the degradation of Verapamil hydrochloride in water. To test the efficacy of rabeprazole, levofloxacin and rifabutin triple therapy vs.

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Are viscoelastic tests essential in polytrauma patient resuscitation?. One woman with RM, but none of the fertile women, carried the CTNNA3-associated CNV. Relationships between the temporomandibular joint and the middle ear in human fetuses. Endothelial dysfunction in the coronary microcirculation: a new clinical entity or an experimental finding?. Associations of inflammatory mediators with maternal glucose and with birth size were assessed using multiple linear regression analyses, adjusting for maternal body mass index (BMI), fasting C-peptide, and other potential confounders.

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Endoscopic and histologic changes in gastric mucosa in chronic alcoholics. Evaluation of organochlorine insecticide residue levels in locally marketed vegetables of Jaipur City, Rajasthan, India. A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells. The hypothesis forwarded here links these subgroups of induced cytokines to the various clinical forms of human toxoplasmosis. Processing of the coronavirus MHV-JHM polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a. A comparative study of two low-dose combined oral contraceptives: results from a multicenter trial. It is suggested to establish technical specifications of CM-ECPGs in accordance with the characteristics of CM and international general specification, strengthen the quality evaluation of CM-ECPGs, attach great importance to the regularly update as well as popularization and application of CM-ECPGs. Lack of correlation between membrane CD30 expression and cytokine secretion pattern in allergen-primed naive cord blood T-cell lines and clones.

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Prolonged observation of the cells revealed another phase of NO release 12 hours following initial morphine exposure that was characterized by prolonged NO production. Vascular endothelial growth factor: an attractive target in the treatment of hypoxic/ischemic brain injury. To evaluate the correlation between neural capacity, determined by high-pass resolution perimetry, and thickness of the retinal nerve fiber layer, evaluated by scanning laser polarimetry, in patients with primary open-angle glaucoma or normal-tension glaucoma. Dynamic contrast-enhanced magnetic resonance imaging: definitive imaging of placental function?. Finally, combinational blockade of both pathways in glioblastoma CSLCs suppressed their tumorigenicity, whether transplanted subcutaneously or intracranially, more efficiently than blockade of either alone. The trial seems to exclude a clinically significant effect of 15-30 mg cisapride daily in patients with IBS and constipation during a 12-week treatment period. Evaluation of biological activity of L-methionidase from Pseudomonas putida AC-75 on the basis of in vitro studies. tapetis isolated from corkwing wrasse Symphodus melops suffering vibriosis.

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An Advanced Histologic Method for Evaluation of Intestinal Adenomas in Mice Using Digital Slides. This proof-of-concept study regards pharmacophylogenomics as the updated version of pharmacophylogeny and would enrich the intension and spread the extension of pharmacophylogeny. While microbiological differences between viruses influence prevalence, other variables associated with the way drugs are acquired and used, also play a role. To test whether this disulfide bond is required for catalytic activity, the codons for residues Cys69 and Cys238 were randomized individually and simultaneously by PCR-based mutagenesis to create random replacement libraries for these positions. We retrospectively reviewed the medical records of 9 Sophono patients and 10 BAHA patients. Conversely, few data regarding the outcome in adulthood of childhood SSNS have been published previously.

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Between 1994 and 1999, 88 younger patients (mean age, 58 years) and 167 older patients (mean age, 72 years) were enrolled in this prospective nonrandomized clinical trial. Staffing primary care in 1990: the findings and policy implications. Fast and simple assessment of VPE was possible by using a highly automated interactive video overlay system suitable for application in a routine pathology laboratory. First, following fructose-pretreatment for various durations (1 day, 1 week or 3 weeks), 1-day-fructose-pretreatment induced hypertriglyceridemia and enhancement of APAP-nephrectoxicity simultaneously. The key in determining whether a physician-patient relationship has been established is whether the patient reasonably relied upon advice given or had an expectation of treatment. Subjects were engaged in 1 of 3 different cognitive tasks, including matching-to-sample, visual-spatial discrimination, and a motor task. Together, these results led to the conclusion that the 14- to 18-kDa antigen is a phospholipomannan. Aortic stiffness was evaluated by measuring the carotid-femoral pulse-wave velocity non-invasively. Both the in vitro microbiologic activity of an antibiotic drug and its pharmacokinetic characteristics are important criteria to be considered when predicting clinical efficacy.

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Knowledge of the equine intestinal immune response to cyathostomins is limited. All blood lipid analysis were done at the J Alick Little Lipid Research Laboratory, University of Toronto, which is standardized according to the National Heart, Lung, and Blood Institute, Centers for Disease Control (Atlanta) Lipid Standardization Program. Hysteroscopic Evaluation in Patients with Thickened Endometrium at Vaginal Ultrasound Examination. The German version of the Edinburgh Postnatal Depression Scale (EPDS) served to determine the depressive disorder of our patients. A clinicopathological study of mediastinal masses operated in a tertiary care hospital in Eastern India in 3 years with special reference to thymoma. Skin sensitivity to the 4 most common genera in patients with respiratory allergy. IL-6 production by adult cerebral cortical tissue could be further stimulated, but it was less readily achieved compared to the tissue of infants. As a paradigm for such processes, we discuss the recognition of Klebsiella pneumoniae by alveolar macrophages and monocyte-derived macrophages in the absence of serum.

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Kinetics of multivalent antigen DNP-BSA binding to IgE-Fc epsilon RI in relationship to the stimulated tyrosine phosphorylation of Fc epsilon RI. The data of morphometry were subjected to 12-variate cluster analysis using a mainframe computer. Among exploratory methods, CT with injection of air occupies a prominent place as it enables neurinomas located inside the internal auditory canal to be diagnosed at an early stage. In the current study, chronic stress was shown to impair learning and memory functions, in addition to reducing in hippocampal Adenosine monophosphate-activated protein kinase (AMPK) activity. Results in this small group of subjects suggest that docusate sodium mini-enemas may have advantages in the management of bowel evacuation in individuals with spinal cord injury. The disquieting increase in the mortality of drug addicts observed in recent years cannot be ascribed to only one or a few well defined causes, such as the spread of the HI virus or AIDS, changes in drug consumption habits of multiple dependents or ineffective therapeutic measures. The hypothesis that cortical processing of the millisecond time range is performed by latency competition between the first spikes produced by neuronal populations is analyzed. Characterization of viability, mitochondrial activity, acrosomal integrity and capacitation status in boar sperm during in vitro storage at different ambient temperatures. Comparison of short and long zidovudine regimens is appropriate.

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Isolation of a protein from the parasporal crystal of Bacillus thuringiensis var. The current data demonstrate that GABAergic mechanisms in the RVLM are responsible for the hypotension and sympathoinhibition of moxonidine. Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis. Carcinogens and cancer: reviewing carcinogens and recommending safeguards. After kindling, the benzodiazepine receptor antagonist, flumazenil, reduced defensive response to rats in a drug-dependent manner.

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It has a pH optimum of 6.5 and shows aryl esterase characteristics. The nephrotic syndrome in Ghana: clinical and pathological aspects. A novel data evaluation scheme is demonstrated by the application of a nonlinear fit to various intervals of lag times, which can detect relevant systematic errors. Multiple nucleosome positioning with unique rotational setting for the Saccharomyces cerevisiae 5S rRNA gene in vitro and in vivo. Improved flow straighteners reduce thrombus in the NASA/DeBakey axial flow ventricular assist device.

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Thus it fulfils the requirements both for follow-up of conservatively managed AAAs and endovascularly treated aneurysms. The cytoplasm of these cells became progressively loaded with glycogen followed by lipid droplets. In these cases there is a high likelihood for diffuse disease to develop from bronchogenic spread. In stage II melanoma patients we cannot prove any therapeutical effect of BCG therapy. Experiment 2 extended these findings, presenting oscillations in which the frequency changed during the trial.

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Conversely, deletion of the entire receptor results in an embryonic lethality by Embryonic Day 7.5. In this regard, the fibrinogen molecule is well adapted both for network polymerization and for subsequent dismantling. However involvement of central nervous system is a severe cleocin renal dosing complication of HUS. We examined regulation of the Arabidopsis thaliana gene RPP8 (resistance to Hyaloperonospora arabidopsidis, isolate Emco5). Cloning of the human tuftelin gene and partial sequencing of a number of exons have also been achieved. The authors present a literature review on the studies of melatonin in treatment of fibromyalgia, headache, irritated bowel syndrome, chronic back pain and rheumatoid arthritis. In addition to the antithrombotic action, effects of low-dose aspirin on cardiac remodeling could be associated with favorable hemodynamic effects, as reflected by a lower heart rate for the same cardiac output.

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In the present study we found that a hexapeptide: Arg-Gly-Asp-Val-Tyr-Thr is the smallest size fragment of HLA-DQ having both cellular and humoral immunosuppressive activity. Two recent papers report the cloning of human and Xenopus homologues of one of these yeast genes, called MAD2 (for mitotic arrest deficient-2)(1,2). The modification of the many-body potential has a general nature and can be applicable to metals with different characteristics of the electron structure as well as for many different molecular and solid state systems experiencing phase transitions. The aim of the present study was to compare the cost effectiveness of three different techniques. Butylated hydroxytoluene, iron-chelators, superoxide dismutase, mannitol and dimethylsulfoxide did not block the inactivation of SDH, indicating that lipid-derived radicals, iron-oxygen complexes, superoxide and hydroxyl radicals do not participate in SDH inactivation. B3 breast lesions determined by vacuum-assisted biopsy: how to reduce the frequency of benign excision biopsies. SN50, a direct inhibitor of NF-kappaB translocation into the nucleus also protected macrophages from LPS-mediated toxicity.

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We recently reported the use of an exhaustively stereodiversified library based on endomorphin-2 (1) to discover mu opioid receptor (MOR) ligands of type 2-4. Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity. As an investigational technique, catheter-assisted transcervical sonography offers a new diagnostic approach to how much does protonix cost without insurance imaging of the first-trimester human embryo. These reactions provide convenient and practical routes for the synthesis of enynones with a wide range of substitution groups. To compare gut microbiota in impoverished children versus children of high socioeconomic status living in the same urban area in Brazil.

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Scrapie is a degenerative disease of the central nervous system of sheep and goats. In contrast, alpha beta TcR transgenic spleen cells were activated only by dendritic cells but not by cortical epithelial cells. In mammals, the cloned low-threshold heat receptor, vanilloid receptor subtype 1 (VR1), is involved in the genesis of thermal hyperalgesia after inflammation. Furthermore, unlike wide spectrum inhibitors of tyrosine phosphatases such as pervanadate, calpeptin appeared to inhibit a subset of phosphatases. Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes. The lower SG, ansae subclaviae, and upper SG were removed in a stepwise manner. Continuing bonds and adjustment at 5 years after the death of a spouse.

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