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Amitrix (Amitriptyline)

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Amitrix is not FDA-approved to treat insomnia, but one of the side effects of the medication is sleepiness, especially when you first start taking it. Because of this, you may want to take it in the evening or before bedtime when you first start taking it.

Other names for this medication:
Amiline, Amitin, Amitone, Amitrac, Amitrip, Amitrol, Amitryn, Amitwix, Amixide, Amize, Amizep, Amline, Amrea, Amsha, Amtipax, Amypres, Axtrip, Chlotrip, Cotrip, Endep, Eptanol, Gentrip, Kamitrin, Libral, Librodep, Mitrip, Psycomer, Raitrip, Teedep, Tridep, Tryline, Typlin, Typteez, Vanatrip, Zodep

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Also known as: Amitriptyline


Amitrix (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitrix is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amitrix dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitrix are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Amitrix if you are allergic to Amitrix components. Do not take Amitrix if you are pregnant, planning to become pregnant, or are breast-feeding. Be careful with Amitrix if you suffer from or have a history of a history of heart attack, stroke, bipolar disorder (manic-depression), schizophrenia or other mental illness, diabetes, overactive thyroid, glaucoma, problems with urination, heart disease, seizures. Be careful with Amitrix if you are taking guanethidine (Ismelin), disulfiram (Antabuse), heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), quinidine (Cardioquin, Quinidex, Quinaglute), cimetidine (Tagamet). Avoid alcohol. Be careful! Taking Amitrix you can become suicidal. Be careful when you are driving or operating machinery. Be careful with Amitrix if you are going to have a surgery. It can be dangerous to stop Amitrix taking suddenly.

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Hypercholesterolemia and its correlates in Taiwanese elderly people. Since the first report of sheep cloning from an adult cell in 1997, the potential applications of reproductive cloning in human medicine have been envisaged amidst a flurry of moral debates. Secretion of glutathione S-transferase isoforms in the seminiferous tubular fluid, tissue distribution and sex steroid binding by rat GSTM1. The atrazine biosensor is fabricated on tyrosinase-immobilized vertical growth TiO(2) nanotubes (Tyr/TiO(2)-NTs), based on the inhibition of tyrosinase by atrazine. During reperfusion mitochondria from mM-Ca livers accumulated calcium and respiratory activity declined.

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