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Amitryptyline (Amitriptyline)

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Amitryptyline is sometimes used off-label, meaning not FDA approved, for certain conditions. Some providers will use this medication to treat nerve pain. This can be helpful for people who have diabetes or fibromyalgia and haven't felt relief with other medications.

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Also known as: Amitriptyline


Amitryptyline (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amitryptyline is a prescription medicine used to treat symptoms of depression.


Take Amitryptyline tablets orally with water, with or without food. Take Amitryptyline for one to four times a day at the same time. The treatment can be resulting after 4 weeks. If you want to achieve most effective results do not stop taking Amitryptyline suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amitryptyline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amitryptyline if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amitryptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amitryptyline is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amitryptyline is not approved for use by anyone younger than 12 years old.

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