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Anastrozole

Anastrozole is an aromatase inhibitor approved by the U.S. Food and Drug Administration (FDA) to treat postmenopausal women diagnosed with advanced-stage or metastatic hormone-receptor-positive breast cancer.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

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Description

Anastrozole is approved to treat certain types of breast cancer in women who’ve gone through menopause.

What breast cancer is

Breast cancer develops when cells in your breast start to grow and multiply (make more cells) more quickly than usual. With most breast cancers, the abnormal cells are encouraged to grow by the hormone estrogen.

If your breast cancer is stimulated by hormones, such as estrogen, certain tests will show that the cancer cells have receptors (attachment sites) for those hormones. This type of breast cancer is called hormone receptor-positive (HR+).

HR+ cancers can be treated with hormone therapies that lower the estrogen level in your body. And because most breast cancer is HR+, hormone therapies are also sometimes used to treat breast cancer whose receptor status isn’t known.

What Anastrozole does

Anastrozole is a hormone therapy that’s used to treat certain forms of breast cancer. It’s a type of drug called an aromatase inhibitor. Anastrozole works by stopping (inhibiting) the action of an enzyme called aromatase. (Enzymes are certain proteins that help chemical reactions to happen inside your body.)

The aromatase enzyme makes estrogen out of steroid hormones in your body, such as testosterone. Aromatase is found in various tissues, including your brain, fat, and skin.

Before menopause, estrogen is mainly produced by your ovaries. And just a small amount is made by the aromatase enzyme. But after menopause, your ovaries stop producing estrogen. At that point, the aromatase enzyme is the main way that your body makes estrogen. (And in men, estrogen is also mainly produced by the aromatase enzyme.)

By stopping aromatase from working, Anastrozole lowers the amount of estrogen in your body. This helps to stop estrogen from encouraging breast cancer to grow and spread.

How long does it take to work?

Anastrozole will start working soon after you begin taking it. But you won’t be able to notice this. Your doctor may order different kinds of tests during your treatment to check and see if the drug is working for you.

Dosage

This medicine may be taken on an empty stomach or with food. Take this by mouth exactly as directed usually once a day. This is a potent medication. Do not increase your dose, or take this more often than directed. If you want to achieve most effective results do not stop taking Generic Anastrozole suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Anastrozole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Anastrozole can interact with several other medications.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Anastrozole and other medications

Below are lists of medications that can interact with Anastrozole. These lists do not contain all the drugs that may interact with Anastrozole.

Before taking Anastrozole, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Anastrozole and tamoxifen

Like Anastrozole, tamoxifen is a hormone therapy that’s used to treat breast cancer. But taking tamoxifen with Anastrozole can lower the amount of Anastrozole in your body. This can make Anastrozole less effective for you.

Because of this interaction, you shouldn’t take tamoxifen with Anastrozole. However, if recommended by your doctor, it’s fine to take Anastrozole after you’ve finished taking tamoxifen.

Anastrozole and drugs that contain estrogen

Taking Anastrozole with drugs that contain estrogen could make Anastrozole less effective for you. Because of this, you shouldn’t take these types of drugs while you’re using Anastrozole.

Examples of drugs that contain estrogen include:

  • hormone replacement therapy (HRT)
  • vaginal estrogen products, such as creams and tablets
  • birth control medications, such as pills, patches, and vaginal rings
If you have questions about using medications that contain estrogen with Anastrozole, talk with your doctor.

Anastrozole and herbs and supplements

There aren’t any herbs or supplements that have been specifically reported to interact with Anastrozole. However, you should still check with your doctor or pharmacist before using any of these products while taking Anastrozole.

For example, it’s possible that supplements such as red clover or wild yam could make Anastrozole less effective. (These supplements are used by some women to reduce menopausal symptoms, such as hot flashes.)

This interaction is possible because these supplements contain phytoestrogens, which are weak estrogen-like substances found in certain plants. There isn’t enough information available to say for sure whether taking phytoestrogens can affect your breast cancer treatment or not.

Be sure to talk with your doctor before taking any herbs or supplements with Anastrozole.

Anastrozole and foods

There aren’t any foods that are known to interact with Anastrozole. Talk with your doctor to find out if there are any foods you should avoid during Anastrozole treatment.

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UK National COPD Resources and Outcomes Project (NCROP): 2008 National audit data presents an opportunity to highlight the areas for improvement in COPD care in the ageing population. Turpin, personal communication), but in this method absorption of laser light may impair the integrity of the sample. Alphaherpesviruses, including the human pathogen herpes simplex virus 1 (HSV-1) and the animal herpesvirus pseudorabies virus (PRV), encode a membrane-bound glycoprotein, gD, that can interfere with subsequent virion entry. The endogenous cannabinoid system protects against colonic inflammation. Entanglement and Bell Correlation in Electron-Exchange Collisions. Both presented prenatal growth retardation and severe postnatal growth retardation. Generally, resolution of the hemorrhage requires weeks and months in patients treated conservatively. Synovial fluid in the temporomandibular joint (TMJ) acts as a lubricant and shock absorber, facilitating smooth jaw movements by reducing friction and cushioning the articular cartilage and other tissues in the TMJ. Sendide, a tachykinin NK1 receptor antagonist, was tested for antagonism against scratching, biting and licking responses elicited by intrathecal (i.t.) injections of various tachykinin receptor agonists, N-methyl-D-aspartate (NMDA), somatostatin and bombesin, in mice. Various other strategies have been studied in vitro to prevent TTR amyloidosis, including gene therapy, immunization, dissolution of TTR aggregates, and free radical scavengers, but none of them is ready for clinical use so far.

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These data provide the first insights into the cortical neuronal network involved in sensing airway irritation and modulating coughing in humans. The risk of tardive dyskinesia, the relative risk, incidence rate, and incidence rate ratio were estimated. Here, we review recent advances in the development of cellular HD models and approaches aimed at cell regeneration with human stem cells. It was also shown that (13)C-(1)H and (1)H-(1)H RDCs, which are the easiest to measure, are also the most important and information-rich data for the order matrix calculation. Evidence for an association between Chlamydia psittaci and ocular adnexal lymphomas. On the basis of these morphological date, the tumour may be defined as an astrocytoma, the blastic tendency of which cannot be affirmed, other than on the basis of the presence of mitotic figures. Malignant and Metastatic Pheochromocytoma: Case Report and Review of the Literature. RT-PCR and telomerase activity data demonstrated that persistent exogenous hTERT expression significantly inhibited the differentiation of neurons from NT2 cells. This study evaluated the potential benefit of a split-parotid delineation approach on the parotid gland in the treatment planning of patients with nasopharyngeal carcinoma (NPC). The role of Enterococcus faecalis in orthopaedic peri-implant infections demonstrated by automated ribotyping and cluster analysis.

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