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Apgel (Adapalene)

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Apgel is an expensive drug used to treat mild to moderate acne. This drug is slightly more popular than comparable drugs. It is available in generic and brand versions. Over-the-counter Apgel is now available without a prescription.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

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Floxin, Flonase, Xanax, Duphaston, Propecia, Larosh, Asthalin, Pedrox, Coriem, Anabol, Rhinocet, Cravit, Adapalene,

Also known as: Adapalene


Apgel is a third-generation topical retinoid primarily used in the treatment of acne. Apgel is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Apgel gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Apgel works under the skin surface to unclog pores and clear up pimples. Apgel is also known as Adapalene, Adapen, Adaferin. Generic name of Apgel is Adapalene.


It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Do not apply this medicine to windburned or sunburned skin or on open wounds.

Do not use this medicine in or around the eyes, lips, or inside of the nose. Spread the medicine away from these areas when applying. If the medicine accidently gets on these areas, wash with water at once.

Apply the medicine to clean, dry areas of the skin affected by acne. Rub in gently and well. Wash your hands afterwards to remove any medicine that may remain on them.

To help clear up your acne completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a short time. If you stop using this medicine too soon, your acne may return or get worse.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (gel): For acne: Adults and teenagers—Apply a small amount as a thin film once a day, at least one hour before bedtime. Apply the medicine to dry, clean areas affected by acne. Rub in gently and well. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Apgel are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Apgel if you are allergic to Apgel components. It is not known whether Apgel will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Apgel in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Apgel, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Apgel. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Apgel suddenly.

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Early use of cardiac troponin-I and echocardiography imaging for prediction of myocardial infarction size in Wistar rats. To investigate the possibility of constructing eukaryotic expression vector for human glial derived neurotrophic factor (hGDNF), transfecting it to spinal cord tissue of rats so as to treat acute spinal cord injury. We use ciprofloxacin (CIP) as a sample drug: direct penetration of CIP through cell membranes is problematic due to its high polarity. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Influence of betaine and salinomycin on intestinal absorption of methionine and glucose and on the ultrastructure of intestinal cells and parasite developmental stages in chicks infected with Eimeria acervulina.

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Among these proteins are three structure-selective nucleases (SSEs). Streptococcus pneumoniae is a leading cause of childhood morbidity and mortality worldwide, despite the availability of effective pneumococcal vaccines. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Better understanding of the diet-microbiota interplay and large-scale studies to evaluate the efficacy of dietary modification and gut microbiota modulation in reversing dysbiosis and restoring health could offer novel preventative and/or therapeutic strategies against westernized diseases, which are now considered the chief threat to public health. Paradoxically, GRKO kidneys showed little donor MHC induction and less inflammatory infiltration. To assess the effects of benefit design change (BDC) on medication adherence and persistence (including switch in therapy), drug costs, and total healthcare costs. In addition to various biological factors, it is suggested that the poor correlation could be quite possibly due to the inadequacy of available statistical tools to compensate for biases in the data collection methodologies. Increasing the awareness of the organ donation: the University of Michigan Transplant Center partners with the community. It is not specific and for that in some cases a column chromatographic cleanup is necessary.

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Physicomechanical evaluation of low-shrinkage dental nanocomposites based on silsesquioxane cores. Interphase mapping was able to extend the ability to resolve and order sequences up to two orders of magnitude beyond localization on banded or unbanded chromosomes. The results of the present study have shown that in a group of dental students trained in manual brushing technique, where efficacy was similar with the 3 toothbrushes tested, there is no evidence of greater gingival abrasion with either Braun Oral-B Plak Control Ultra or 3D when compared with a manual brush. The isolation and identification of trichothecene metabolites from a plant pathogenic strain of Myrothecium roridum. Inhibition of cyclooxygenase and nitric oxide synthase in hypoxic vasoconstriction and oleic acid-induced lung injury.

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Intranasal midazolam for premedication of children undergoing day-case anaesthesia: comparison of two delivery systems with assessment of intra-observer variability. Differential response of buddleia (Buddleia davidii Franch.) to ozone. Four species of Stephanostomum are described from various sites in Seriola dumerili from off Corsica, France. To investigate the presence of MIF in nasal polyp tissues and the influence of a MIF activity inhibitor on dexamethasone effects on IL-6 production. The most stable improvement was obtained from a combination of levopa with cyclodol in patient with rigid-akynetic-trembling manifestations of parkinsonism. Treatment with COC led to elevated fasting blood glucose, insulin, corticosterone, triglycerides (TG), TG/HDL-cholesterol ratio, insulin resistance (IR) and impaired glucose tolerance. A similar tendency to stabilisation was noticed in the curves which had not shown deterioration. Proportional hazards regression analyses that controlled for demographic and social characteristics, as well as reproductive attitudes, confirmed this cohort effect (hazard ratios, 1.5-2.6). The risk of dementia is slightly higher in people with minimal exposure to benzodiazepines but not with the highest level of exposure.

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Successful treatment with ICSI of infertility caused by azoospermia associated with adrenal rests in the testes: case report. A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts. The chick hindbrain epithelium is segmented early in its development. Although porcine studies have highlighted successful NOTES retroperitoneal procedures, the abundant human retroperitoneal adipose tissue challenged the translation of porcine research to humans. A survey was conducted to collect the data from the hospitalized children at 12 participating hospitals during the winter of 2007.

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Cholesterol-lowering effects of a new isolated soy protein with high levels of nondenaturated protein in hypercholesterolemic patients. The aim of the present study was to investigate the effect of weight reduction in obese Caucasian children on insulin sensitivity, sex hormone-binding globulin (SHBG), DHEAS and the hypothalamo-pituitary-gonadal axis. Our previous study in healthy middle-aged men showed that moderate alcohol consumption increases cellular cholesterol efflux and EST. The aim of this cohort study is to compare the survival rate of implants placed in augmented sinus to implants placed in native bone in the posterior maxilla. The patients were diagnosed with carcinoma of the pancreatic head (8 cases), ampullary carcinoma (1 case), and carcinoma of the distal part of the common bile duct (1 case). The diagnostic possibilities for differentiation from vascular and nonvascular space-occupying processes in that region are discussed. Impact of Ig-Therasorb immunoapheresis on stability of xenogeneic ex vivo porcine liver perfusion--value of aminotransferases and flow rates for the assessment of metabolic graft viability.

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