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Asacol (Mesalamine)
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Asacol

Mesalazine is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease. It is generally used for mildly to moderately severe disease. It is taken by mouth or rectally. The formulations which are taken by mouth appear to be similarly effective.

Other names for this medication:
Canasa, Mesacol, Mesalamine, Pentasa, Rowasa, Tidocol, Walasa

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Asacol, Lioresal, Strattera, Danocrine, Xanax, Omnicef, Mircette, Trigem, Ection, Sioban, Nifatenol, Gloworm,

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Also known as: Mesalamine

Description

Mesalamine is used to treat and prevent mild to moderately active ulcerative colitis (an inflammatory bowel disease). It works inside the bowels to reduce inflammation and other symptoms of the disease.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain mesalamine. It may not be specific to Asacol 800. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not stop using this medicine without checking first with your doctor.

Keep using this medicine for the full time of treatment, even if you begin to feel better after a few days. Do not miss any doses.

Swallow the capsule or tablet whole. Do not open, break, crush, or chew it.

If you are taking the Asacol® delayed-release tablet:

You may take this medicine with or without food. Drink extra fluids so you will urinate more often and help prevent kidney problems (eg, kidney stones).

Take the Asacol® HD tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.

You should take the Lialda® tablets with food. All other brands of capsules and tablets can be taken with or without food.

If you have trouble swallowing the Delzicol® capsule, carefully open the capsule and take out the 4 tablets. Swallow the tablets whole and make sure all 4 are taken at the same time as one dose. Do not cut, break, crush, or chew them.

The contents of the Pentasa® capsule may be sprinkled onto soft foods (eg, applesauce or yogurt) if you have trouble swallowing the capsule. The mixture must be swallowed right away without chewing.

If you are taking the delayed-release capsule, extended-release capsule, or delayed-release tablet, part of the capsule or tablet may pass into your stool after your body has absorbed the medicine. Contact your doctor if this happens more often than 1 or 2 times.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For the treatment of ulcerative colitis: For long-acting oral dosage form (delayed-release capsules): Adults—800 milligrams (mg) 3 times a day. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually not more than 2400 mg per day, divided in 2 doses. Children younger than 5 years of age—Use and dose must be determined by your doctor. For long-acting oral dosage form (delayed-release tablets): Asacol®: Adults—800 milligrams (mg) (two 400 mg tablets) 3 times a day for 6 weeks. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor: Weighing 54 to 90 kilograms (kg)—1200 mg (three 400 mg tablets) in the morning, then 1200 mg (three 400 mg tablets) in the afternoon for 6 weeks. Weighing 33 to less than 54 kg—1200 mg (three 400 mg tablets) in the morning, then 800 mg (two 400 mg tablets) in the afternoon for 6 weeks. Weighing 17 to less than 33 kg—800 mg (two 400 mg tablets) in the morning, then 400 mg (1 tablet) in the afternoon for 6 weeks. Children younger than 5 years of age or weighing less than 17 kg—Use and dose must be determined by your doctor. Asacol® HD: Adults—1600 milligrams (mg) 3 times a day for 6 weeks. Children—Use and dose must be determined by your doctor. Lialda®: Adults—2.4 to 4.8 grams (g) once a day. Children 5 years of age and older—Dose is based on body weight and must be determined by your doctor: Weighing more than 50 kilograms (kg)—4.8 grams (g) once a day for 8 weeks. Then 2.4 g once a day. Weighing more than 35 to 50 kg—3.6 g once a day for 8 weeks. Then 2.4 g once a day. Weighing 24 to 35 kg—2.4 g once a day for 8 weeks. Then 1.2 g once a day. Children younger than 5 years of age or weighing less than 24 kg—Use and dose must be determined by your doctor. For long-acting oral dosage form (extended-release capsules): Adults— For Apriso®: 1.5 grams (g) (four capsules) once a day as a single dose in the morning. For Pentasa®: 1 g (four 250 milligrams [mg] capsules or two 500 mg capsules) 4 times a day. Children—Use and dose must be determined by your doctor. For prevention of ulcerative colitis: For long-acting oral dosage form (delayed-release capsules): Adults—1600 milligrams (mg) per day, taken in divided doses. Children—Use and dose must be determined by your doctor. For long-acting oral dosage form (Asacol® delayed-release tablets): Adults—1600 milligrams (mg) (four 400 mg tablets) per day, taken in 2 to 4 divided doses. Children—Use and dose must be determined by your doctor. For long-acting oral dosage form (Lialda® delayed-release tablets): Adults—2.4 grams (g) once a day. Children—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Asacol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Hygienic evaluation of immune and endocrine systems and modifications of their relationship in reproductive-age women working under exposure to chemical factors in activated carbon emissions. Oxidation of LDL and VLDL increases, whereas HDL becomes a proinflammatory molecule. Stress on the vocal cords caused by phonation during noise exposure. NFkappaB activation was evaluated by electrophoretic mobility shift assay of whole cell extracts and by immunohistochemical analysis on cytospin preparations. Possible involvement of bcl-2 in regulation of cell-cycle progression of haemopoietic cells by transforming growth factor-beta1. In vitro microsomal assays suggested that compounds (R)-1 and (S)-1 are not metabolized rapidly, and PAMPA assay indicated moderate permeability through the membrane. Slipped capital femoral epiphysis is a common adolescent hip disorder and when patients present at an age younger than 10 years, it is atypical and there is often some identifiable associated metabolic or endocrinologic abnormality. Under conditions where protochlorophyllide reduction and thus chlorophyll synthesis were inhibited, chlorophyll disappeared quickly in a mutant lacking all five SCPs.

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Laparotomy in a jaundiced, anorectic cat revealed an obstructed common bile duct. Optical analysis of spatially periodic patterns in nematic liquid crystals: diffraction and shadowgraphy. Diols, formed following hydrolysis of mustard and longer-chain sulfur vesicants, may be analyzed using both methods with LC-ESI-MS providing improved chromatographic peak shape. They provide in vivo evidence supporting direct or indirect regulation of many new transcripts by progesterone. Mutations in the WASP WH1 domain were found to influence both the function and structure of the WASP. The authorities in the hospitals and EMS administration should improve the barriers which interfere with the efficiency of a paramedic and cause gross humiliation to the patients, and the Health authorities should impart proper education and training to the paramedics. Furthermore, we present some novel splice form predictions with high-scoring protein domain homology and point out that the detection of splice form specific protein domains helps to answer questions concerning hereditary diseases. The authors caution against use of dry, powdered forms of topical antibiotics in fresh dental extraction wounds.

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mansoni with or without recombinant tumor necrosis factor alpha treatment. Previous studies have uncovered some of the molecular mechanisms that underlie the functions of RNA-binding proteins in stem cells in invertebrate species. Quantitative data obtained by means of design-based stereology can add valuable information to studies performed on a diversity of organs, in particular when correlated to functional/physiological and biochemical data. To prevent recurrence we advise functionally shortening the tubing by tucking it to the right upper quadrant above the liver and also provide some omental coverage between the bowel and band tubing if possible. There are both diagnosed and undiagnosed cases of FH in primary care danocrine not known to secondary care.

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The results indicate that the shocks function to disrupt monotony and not to regulate negative emotional experience in general. The failure mechanics of some bone-ligament-bone constructs vary with the rate of tensile load application. The results of the present study indicate support for embryo donation among a subset of the Swedish population of reproductive age. Here we use a mutant of Ki-ras which is temperature-sensitive for transformation to investigate the kinetics of activation of the phosphodiesterase-mediated turnover of phosphatidylcholine. Treatment of animals with p-CPA produced a significant increase in time out from the illuminated part of the chamber and in time of locomotor activity in the illuminated part of the chamber. Scientific literature represents the main source of information, which yielded the herein discussed substances and therapeutic targets, which might become relevant for doping controls in the future. We sought to determine the clinical and neuroradiological features of intracranial vertebrobasilar artery dissection. The vectors contained the lacZ alpha gene as a reporter of mutations. The surface tension is increased linearly with the bulk concentration of the solute c(b) and the interaction range lambda. Many Saccharomyces cerevisiae genes encode antisense transcripts, some of which are unstable and degraded by the exosome component Rrp6.

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