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Compazine (Prochlorperazine)

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Compazine is a phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Compazine is an antipsychotic agent that works to promote postsynaptic inhibition of dopaminergic neurons.

Other names for this medication:
Bukatel, Compro, Emidoxyn, Eminorm, Ingametil, Meditil, Neurocin, Neurograin, Neurolice, Neuromol, Neuronit, Novapar, Nuroflow, Nuropar, Prochlorperazine, Procomp, Psygrain, Stemetil, Swigrain, Vasograin, Vertipro, Vestil

Similar Products:
Clarinex, Loxitane, Alprostadil, Noroxin, Deltasone, Emperide, Solacap, Deoten, Biofen, Nevilast, Madol, Himzolam,

Also known as: Prochlorperazine


Prochlorperazine suppository is used to control severe nausea and vomiting. This medicine should not be used to treat behavioral problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain prochlorperazine. It may not be specific to Compazine. Please read with care.

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

Do not take rectal suppositories by mouth or use it in the vagina.

To use the suppository:

If the suppository is too soft to insert, chill it in the refrigerator for 20 to 30 minutes or run cold water over it before removing the wrapper. Remove the wrapper and moisten the suppository with cool water. Lie down on your side and use your finger to push the suppository well up into the rectum. Make sure to wash your hands with soap and water before and after using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For rectal dosage form (suppository): For severe nausea and vomiting: Adults—25 milligrams (mg) 2 times a day. Children—Use and dose must be determined by your doctor.


If you overdose Generic Compazine and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Compazine dosage information

Side effects

The most common side effects associated with Compazine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

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The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Clinical and microbiological efficacy and side effects have been evaluated. Design, synthesis, and biological evaluation of 1,5-diaryl-1,2,4-triazole derivatives as selective cyclooxygenase-2 inhibitors. Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells. The mechanisms for minimizing energy expenditure in human locomotion. Procaine (Gerovital): no effect on the rehabilitation result in patients with back or hip disease.

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Impaired glucose tolerance precedes but does not predict insulin-dependent diabetes mellitus: a study of identical twins. In particular, gene flow from eukaryotes to prokaryotes is rarely documented with strong support, which is unusual since prokaryotic genomes appear to readily accept foreign genes. We present a 4-year-old patient with partial rupture of the quadriceps femoris muscle. We assessed frequency and risk estimate of pituitary-adrenal dysfunction. Predialysis education helps patients choose dialysis modality and increases disease-specific knowledge. The 17 principal investigators participating in the Fetal Myelomeningocele Consortium were asked to participate in an anonymous online survey regarding the current practice of maternal-fetal surgery for neural tube defect repair and results were tabulated. The involvement of oxidative stress, of the extracellular signal regulated kinase and of the transcription factors nuclear factor kappa-light-chain-enhancer of activated B cells and nuclear factor of activated T cells was demonstrated. Angiotensin caused an increase of the urinary excretion of electrolytes in hypertensive patients and a decreased electrolyte excretion in normotensives. Patient assessment of treatment at 3 and 7 days was significantly better in the sulindac group than in the ibuprofen group (p less than 0.025). Ibudilast mildly suppressed MBP-induced proliferation of T cells in regional lymph nodes, the secretion of interferon-gamma from T cells activated by MBP in CFA, and the secretion of tumor necrosis factor-alpha from macrophages.

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