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Differin (Adapalene)

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Differin is used to treat acne. It may decrease the number and severity of acne pimples and promote quick healing of pimples that do develop. Differin belongs to a class of medications called retinoids. It works by affecting the growth of cells and decreasing swelling and inflammation.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

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Ticlid, Motilium, Soma, Atarax, Microzide, Imdur, Imitrex, Rulide, Eldepryl, Atbeta, Zentir, Ericiclina, Pantary, Helikit, Fluvoxin, Alzep, Karpam, Ginac,

Also known as: Adapalene


Differin is a third-generation topical retinoid primarily used in the treatment of acne. Differin is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Differin gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Differin works under the skin surface to unclog pores and clear up pimples. Differin is also known as Adapalene, Adapen, Adaferin. Generic name of Differin is Adapalene.


Usual Adult Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Lotion: Apply a thin film of lotion to the entire face and other affected areas of the skin once daily, after washing gently with a mild soapless cleanser. Dispense a nickel size amount of lotion (3 to 4 actuations of the pump) to cover the entire face. Avoid application to the areas of skin around eyes, lips and mucous membranes.

Usual Pediatric Dose for Acne:

Differin 0.1% cream, 0.1% gel, 0.3% gel: 11 years or less: Safety and efficacy have not been established. 12 to 18 years: Apply to the affected area once a day at bedtime after washing. A thin film should be applied, avoiding eyes, lips, angles of the nose, and mucous membranes. Safety and effectiveness of the lotion formulation in pediatric patients under the age of 12 have not been established.

Detailed Differin dosage information


If you overdose Differin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Differin dosage information

Side effects

The most common side effects associated with Differin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Differin if you are allergic to Differin components. It is not known whether Differin will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Differin in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Differin, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Differin. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Differin suddenly.

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Laparoscopic disconnection of a huge paraumbilical vein shunt for portosystemic encephalopathy. On the other hand, hydrogen peroxide led to a necrosis-like cell death that did not induce caspase activation, phosphatidylserine translocation, or changes in calcium levels. Oxygen transport variables reflect the balance of oxygen delivery and demand. Distal femoral varus osteotomy (FVO) can be indicated for young active patients who have lateral unicompartmental osteoarthritis in a valgus knee originating in the femur. In FTMH formation pattern 2, the opening of the roof of MRS or cystoid space caused an inner lamellar macular hole (ILMH). The thrust produced by the aerators was modelled by an external momentum source applied as velocity vectors into the pond fluid. Infection produced high-titer viremia and demonstrated RVFV tropism for a variety of tissue and individual cell types. Endoscopy showed the bleeding to originate high and lateral to the middle turbinate. For 38 voles error production and activity were simultaneously measured in a series of 7 symmetrical mazes.

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Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women. The status of retinoids in women suffering from hyper- and hypothyroidism: interrelationship between vitamin A, beta-carotene and thyroid hormones. In a 45-year-old nullipara with a grossly enlarged, impacted uterus and total vaginal obliteration, hysterectomy was safely performed by hand-assisted laparoscopy using the Pneumo Sleeve system through a 7. Multiple optical traps are generated by a virtually loss-less transformation of input phase patterns into high-intensity trapping-beams. Together, these data provide first evidence that in polarized acinar cells of the exocrine pancreas GPI-anchored proteins, e.g. Immunohistochemically, there were many lysozyme-positive macrophages in the lymphoid follicles, while the number of CD79a-positive B lymphocytes was scanty. At the maternal-fetal interface, trophoblasts do not express major classical MHC class I molecules (MHCI), HLA-A and -B, to prevent normal T cell responses. Synaptic response size in the CA1 region of the hippocampus in aged rats is reduced for a given stimulus intensity, compared with that elicited in young rats. Overexpression of RAV1 in WRKY6-overexpressing lines abolished their ABA-hypersensitive phenotypes, and the rav1 wrky6-2 double mutant showed an ABA-hypersensitive phenotype, similar to rav1 mutant.

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Adjuvant systemic chemotherapy after putative curative resection of colorectal liver and lung metastases. The subcutaneous injection of estradiol benzoate to neonatal rats at 2 days of age significantly increased grn gene expression on day 10. The concentrations of PAHs were relatively high above 35 cm depth and remained constantly low below this depth. Celiac axis stenosis is a relatively common finding that may require major revascularization during pancreaticoduodenectomy. Crystallization and preliminary analysis of xenobiotic reductase A and ligand complexes from Pseudomonas putida II-B. Imaging studies from our laboratory and others have shown increased glucose uptake in adipose tissue regions assumed to be BAT in humans. The knockdown of fgf22 caused decreased cell proliferation in the midbrain, expanded expression of roof plate and tegmental marker genes, and decreased expression of tectal marker genes, indicating that Fgf22 is required for cell proliferation, roof plate formation, and tectum specification in the midbrain. This mechanism may aid in the protection of the gastric mucosa under inflammatory conditions.

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Reflections on a painful transition: from socialized to insurance medicine in Russia. In the first case, progressively generalizing dystonic symptoms appeared during childhood. An increasing number of preoperative patients are receiving therapy with an oral anticoagulant (warfarin) or antiplatelet drugs to prevent thromboembolic complications. Identification glucophage xr 500 mg oral tablet extended release of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis. This has been the focus of recent large trials and remains a challenging treatment for cerebral ischemic stroke as well as for retinal artery occlusion. We present a Web server where the SYSTERS cluster set of the non-redundant protein database consisting of sequences from SWISS-PROT and PIR is being made available for querying and browsing.

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Is attention-deficit/hyperactivity disorder associated with illicit substance use disorders in male adolescents?. Basophil activation was assessed by alcian blue staining, measurement of histamine release and CD63 expression. Together, these data show that ITH is a prognostic marker in multiple cancers. There was no effect on psychomotor performance (assessed by critical flicker fusion threshold, choice reaction time and digit symbol substitution test) nor on mood (assessed by visual analogue scales). A nationwide, population-based, observational cohort study of consecutive adult OHCA patients with emergency responder resuscitation attempts from January 2005 to December 2012 in Japan. The hydroxy-naphthoquinone lapachol arrests mycobacterial growth and immunomodulates host macrophages. The challenge is now to translate these opportunities into an improved understanding of the complex biology of tuberculosis infection.

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