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Endep (Alprazolam)

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Endep is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Endep, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Endep is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Allam, Alpanol, Alpranex, Alzot, Ansilumirm, Balzam, Besquil, Dazolam, Dipra, Ecsit, Ezoprax, Fluxin, Mebrin, Meloprax, Notence, Notens, Oclam, Pizolam, Rozin, Setlan, Tancalm, Tenan, Tenscure, Trazopin, Zoldac, Zotin

Similar Products:
Duricef, Benicar, Maxalt, Antabuse, Rocaltrol, Abhigra, Medrol, Adipex, Syncodone, Altraz, Piocon, Viocid, Albela, Paxyl, Biomon, Noristerat, Nabal,

Also known as: Alprazolam


Endep (alprazolam) is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is thought that alprazolam works by enhancing the activity of certain neurotransmitters in the brain.

Endep is used to treat anxiety disorders and anxiety caused by depression.

Endep is also used to treat panic disorders with or without a fear of places and situations that might cause panic, helplessness, or embarrassment (agoraphobia).

It is dangerous to purchase Endep on the Internet or outside the United States. The sale and distribution of medicines outside the U.S. does not comply with safe-use regulations of the Food and Drug Administration (FDA). These medications may contain dangerous ingredients, or may not be distributed by a licensed pharmacy.


Take Endep exactly as prescribed by your doctor. Follow all directions on your prescription label. Never use Endep in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in treating your symptoms.

Endep may be habit-forming. Never share Endep with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.

Do not crush, chew, or break a Endep extended-release tablet. Swallow the tablet whole. Call your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms. Do not stop using Endep suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.


If you have been prescribed Endep for medical reasons, the best way to avoid a Endep overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Endep consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Endep XR dosage information

Side effects

The most common side effects associated with Endep are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Endep if:

you also take itraconazole or ketoconazole (antifungal medicines); or you have a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, and others).

To make sure Endep is safe for you, tell your doctor if you have ever had:

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; or kidney or liver disease (especially alcoholic liver disease).

Tell your doctor if you are pregnant or plan to become pregnant. Alprazolam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Endep while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

You should not breastfeed while using alprazolam.

Endep is not approved for use by anyone younger than 18 years old.

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The investigation, which led to the identification of a nurse as the common source, is described. Expression of mRNA for growth factors and cytokines in the renal artery wall of chronically rejected renal allograft. The chronic myelogenous leukemia (CML)-like myeloproliferative disorder observed in the BCR/ABL murine bone marrow transduction and transplantation model shares several features with the human disease, including a high response rate to the tyrosine kinase inhibitor imatinib mesylate (STI571). Even though, the rarity of symptomatic forms and case reports of spontaneous regressions antenatally or after postnatal ultrasound follow-up have reduced indications of nephrectomy which is less and less appropriate. To improve the resolution of the expression mapping we have used a dual in situ hybridization (DISH) technique allowing for a detection of expression of two different mRNAs on the same tissue section. Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins. We conclude that pulmonary haemosiderosis may occur in children with coeliac disease who are on a gluten-free diet.

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Amino acids interfered with the ATA-induced macroautophagy by inhibiting the activation of the kinase Raf-1. Indoor residual spray (IRS) was completely withdrawn in southern villages in Surat in 2002. However, this is the first study to report its role on blood coagulation and fibrinolysis mediated by vascular endothelial cells. With the complexity and change facing leaders and managers today, continuous learning, responsiveness, adaptation and innovation are essential survival skills. The constellation of elevated TGs and decreased HDL cholesterol are recognized as risk factors and constitute the major dyslipidemia in NIDDM. Three dogs became depressed and anorectic and developed a mild (one dog) to severe diarrhea five days postinfection. One group was infused with artificial cerebrospinal fluid (aCSF) and the other with beta HB for 28 days. With the development of dialysis in the 1960s came the agonizing question of who should benefit from the limited number of kidney machines. These fluorescent model drugs delineate the oleic acid induced changes in permeant diffusion with respect to the skin structural features over the 0.3 mm by 0.3 mm skin area imaged per skin sample.

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Radio-iodine and Beam radiation and thyroid supplements play supporting roles. Studies on the replication of an adenolike virus of chickens (CELO). Serum TNF-alpha levels were elevated in patients with ISSc and dSSc and correlated with the presence of pulmonary fibrosis and with the decreased vital capacity of the patients. Then, voxel-by-voxel concentration-time curves based on the gamma-variate function were computed leading to a simulated 4D MRA dataset. Further studies on the cardiac actions of hamycin a polyene antifungal antibiotic. Anti-inflammatory drugs are included as one of the multiple causes. Sinusoidal dilatation is a hallmark of peliosis hepatis, a rare vascular disorder that can be either drug induced or of infectious origin. During the development of alcohol dependence, corticotropin-releasing factor may be recruited, and the neuropeptide Y brain antistress system may be compromised. Moreover, the levels of endogenous tubulin in the brain tissues of scrapie-infected hamsters were significantly lower than that of normal one.

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Risk models that evaluate susceptibility bias enhance interpretation of these intergroup comparisons. The benzodiazepine receptor agonist, diazepam, the serotonin synthesis inhibitor, para-chlorophenylalanine (p-CPA), and the 5-HT(1A) receptor agonist, 8-OH-DPAT, were all found to attenuate morphine and U50,488 analgesia. The factors that dictate the route of T metabolism, and the way by which E3 acts to rescue the ovaries from the development of PCOS under the hypothyroid state are discussed. The Q10 value for the time to peak tension was -2.5 between 35 and 25 degrees C, and -5.0 between 25 to 5 degrees C. Study of melituria in the postpartum period by means of ascending paper chromatography. The expressed NP protein was purified by two steps with metal chelation chromatography and ion exchange chromatography. Vesicles, shed in the extracellular medium by several kinds of normal and tumoral cells, are known to play important roles in cell-cell and cell-matrix interactions and to participate in mechanisms by which tumoral cells acquire metastatic capability and evade immune surveillance. The study presents new opinions of pathogenesis of ovarian cancer and origin of recurrences, including theory of multifocal neoplasia of mesothelium. Infections caused by vancomycin-resistant enterococci (VRE) are associated with increased mortality compared to infections caused by vancomycin-sensitive isolates.

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simiae was a frequent clinical isolate but was rarely associated with disease. The use of MgSO4 in early postoperative period is effective in reducing the incidence of AF after CABG in patients with good ventricular function. During subsequent flattening of these cells into primary endodermal epithelium, numerous filopodia arise from their surfaces. We conclude that the HSV-1 recombinant virus represents a promising tool for production of non-aggregated, immunologically active forms of the E2-661 protein and might have potential applications in vaccine development. Swollen astroglial cells (especially the Bergmann glia) contained considerable quantities of precipitate. Accurate histopathology from low signal-to-noise ratio spectroscopic imaging data. The adducin family of cytoskeletal proteins are known to mediate actin driven cell movements. One group was subsequently treated with polysulphone low-flux dialyzers (F6HPS), the other with polysulphone high-flux dialyzers (F6OS). Chronic kidney disease (CKD) is a common medical condition among children and obsessive-compulsive disorder (OCD) is a frequent, chronic, costly, and disabling disorder among them. Based on sequence similarity and phylogenetic analyses of the homeobox and homeodomain sequences of known Hox genes from cnidarians, we suggest the presence of at least five distinct Hox gene families in this phylum, and conclude that the last common ancestor of the Recent cnidarian classes likely possessed a set of Hox genes representing three different families, the Cnox-1, Cnox-2, and Cnox-5 families.

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An adequate sampling of the prostate to identify prostatic involvement by urothelial carcinoma in bladder cancer patients. Knowledge of the variability in pathogen or indicator concentrations over time at a particular location (e.g. Mutations in either of the bipartite basic domains of the xnf7 NLS inhibit nuclear accumulation, while mutations in the spacer sequences have no effect. Women with suspicious cervical lesions and abnormal Papanicolaou smears were excluded from the noncoring technique. A computer-based 3-dimensional representation of two erythrocyte membrane saturated fatty acids (hexadecanoic acid, 16:0 and octadecanoic acid, 18:0), serum cholesterol and thyroid stimulating hormone (TSH) was performed in 26 hypothyroid patients and in 10 control subjects. Thus an efficiency index that accounts for the period in which P is eliminated from the accessible compartment has been formulated. This tomography system provides robust, quantitative, full 3D image reconstructions with the advantages of high data throughput, single detector-tissue coupling path, and large (1L) imaging domains.

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Patient preferences: survival vs quality-of-life considerations. The antifungal nanocoatings have no hemolytic or cytotoxic effect against red blood cells and blood mononuclear cells, respectively. Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3. Validation of a model of psychosocial determinants of occupational health of geriatric nurses. Lipase activity of the gastric mucosa of man under pathological conditions. This review focuses on recent progress in defining the clinical features and mechanism(s) of statin-induced myopathy. After one year, the dermal microfilarial density was found to increase slightly. The IFM 90 trial was designed to compare conventional chemotherapy (CC) and high-dose therapy (HDT). Somatostatin attenuates microcirculatory impairment in acute sodium taurocholate-induced pancreatitis.

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The pleiotropic effects of each of the PPAR isotypes on vascular and cardiac disease are discussed, with special emphasis on the molecular mechanism of action and on preclinical observations. This bibliography is intended to assist pharmacists by identifying relevant articles that describe cost benefit and cost effectiveness analysis and their implications to pharmacy practice. Influence of various accelerations on the conditioned activity of rats. When 125I-EGF was added to A431 cell cultures at low or high density, at concentrations which corresponded to 10-fold excess of ligand over receptor on the cell surface, most of the 125I-EGF was consumed within 2 h. Finally, the risks of living donation KTx will be discussed based on the reported experiences of other centers.

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Change in respiratory regulation in nitrous oxide-ether anesthesia. A new case of diarrhea caused by medullary cancer of the thyroid body. Anamorelin also has a positive effect on appetite and weight gain. More importantly, in multiple xenograft mouse models, altiratinib combined with bevacizumab dramatically reduced tumor volume, invasiveness, mesenchymal marker expression, microvessel density, and TIE2-expressing monocyte infiltration compared with bevacizumab alone. The optimal delay in the start of chemotherapy following rectal cancer surgery has not yet been identified. The study population was composed of 50 patients with facial nerve palsy who were seropositive for Lyme disease (or had Lyme disease otherwise clinically proven).

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Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance. The transfected cells were selected in the medium containing puromycine. Methods for studying adhesive interactions between bacterial strains are well known, and range from simple macroscopic methods to flow chamber systems with complex image analysis capabilities. Such joints, in order to be included in the study, were required to conform to ARA criteria of activity and usually mild to moderate X-ray changes. To collate the research reported on the various hazards associated with the ultrasonic dental scaler and discuss possible future research areas.

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Plasma concentrations of epinephrine and norepinephrine in anesthesia, trauma and surgery, as measured by a modification of the method of Weil-Malherbe and Bone. This report describes a unique case of multiple cellular and malignant schwannomas of the cranial and spinal nerves in a patient with features of neurofibromatosis 2. In the analysis of the simulated data our algorithm finds the correct number of mixture components (sources) and classifies the action potential waveforms with minimal error. Hemodynamic variables were measured immediately before and after short-term flosequinan administration and after 8 weeks of therapy. Several prospective studies have shown that hyperinsulinemia predicts coronary heart disease, perhaps independently of established risk factors. However, the involvement of other genes which modify the availability of exogenous folate, for example, has been proposed. The present study demonstrated that BMI had influenced to surgical outcomes of OLR.

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The clinical consequences of these shifts in intestinal flora are yet to be explored. Studies of the inhibitory effect of l-triiodo-thyronine on thyroidal I131 uptake in euthyroid persons and patients with exophthalmic goiter. Radical surgery remains the standard of care for early localized disease but this has shown to result in high recurrence rates. Within a prospective randomised study in a total of 100 hip replacements with postoperatively controlled cup position using a computed tomography, we reinvestigated especially the 18 dysplastic and two secondary dysplastic cases. These alterations were more prominent in patients with EOS-PE than in patients with LOS-PE.

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To illustrate the potential benefits of kinetic and kinematic models in the exploration of biomechanical studies as illustrated using a simple 2-D static optimization model of wheelchair propulsion. There are no clear criteria to define insulin resistance in children, and surrogate markers such as fasting insulin are poor measures of insulin sensitivity. The resistance of neuroblastoma (NB) cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis has been attributed to a lack of caspase 8 expression. In our case, the cardiac event occurred 25 minutes after head-down tilt, and the head-down tilt position when combined with pneumoperitoneum may have a fatal influence on high-risk cardiac patients. Mechanisms of increased intracranial pressure in rabbits exposed to head-down tilt. Inhibition of the catalytic activity of purified factor Xa toward its chromogenic substrate suggested that it was the target of the salivary anticoagulant of C.v.

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The few available neuropathological studies of bipolar disorder are reviewed and placed in the context of structural imaging findings. Fracture load and failure types of different veneered polyetheretherketone fixed dental prostheses. This paper provides a brief overview of the CIS and describes the costing of services in the Medical Imaging Division. Nephrogenic ascites is a clinical diagnosis defined as a refractory ascites in patients with end-stage renal disease. Figure I of each issue of MMWR displays on a log scale the ratio of the number of cases reported in the most recently ended 4-week period to that of the mean of the number of cases reported in 15 historical 4-week periods. Time-course analysis showed that viral DNA replication can persist for 5-6 days post-inoculation. We find that central carbon metabolism is built as a minimal walk between the 12 precursor metabolites that form the basis for biomass and one precursor essential for the positive net ATP balance in glycolysis: every pair of consecutive precursors in the network is connected by the minimal number of enzymatic steps.

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Predictors of VTE include recency of cancer diagnosis, cancer site, stage and the type of cancer-directed treatment. Inhalational poisoning by botulinum toxin and inhalation vaccination with its heavy-chain component. We measured spatial profiles of longitudinal velocity and cell length and calculated parameters of cell expansion and division, including rates of local cell production (cells zyrtec dosage chart adults mm-1 h-1) and cell division (cells cell-1 h-1). Ang II further enhances apoptosis of HCAECs via Ang II type 1 receptor (AT1R) activation. Neointimal proliferation leading to restenosis frequently develops after coronary angioplasty.

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We evaluate these features using four different classifiers and yeast protein data. Thermodynamic evidence for conformational coupling between the B and C domains of the mannitol transporter of escherichia coli, enzyme IImtl. A method for determining levels of serum HBs antigen has been developed, applying the principles of the integrating sphere turbidimetric assay (ISTA). In this paper, extensions of the variance components model are used to evaluate heterogeneity in the genetic and environmental variance components due to cost of evista the effects of sex and age (the cutoff between young and old was 43 yrs). A cohort of 34 patients with a suspicion of LQTS was further blindly screened. Eggs laid by hens infected with Newcastle disease virus present a very low risk.

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Possible value of the determination of blood and urinary corticosteroids in clinical medicine. Acute thrombosis of the basilar trunk with massive necrosis of the protuberance and of the peduncle. Chromatographic methods were used for separation and purification. Demographic and all relevant obstetric, personal and family history of breast cancer data were recorded. Although isolates from dogs with pyoderma were frequently resistant to methicillin, multiple drug resistance was uncommon. A bean cDNA clone that specifies a 70 kDa heat-shock protein (hsp70) has been isolated and sequenced. Molecules present in the apical membrane may represent components of adhesion receptors responsible for retina-epithelium interactions. With the exception of the initial rural EMT-D study from Iowa, large communities had a higher rate of prearrest-level neurologic survival than small communities. Pyridoxine responsive seizures contribute a significant proportion to early-onset idiopathic intractable epilepsy in childhood. We found that while both cytokines inhibited LPS-induced NO release, they had distinct and opposite regulatory activities on PGE2 production.

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NK1-immunoreactive puncta and somata were located mostly in the rostral lateral, upper half of the rostral central and medial NST subnuclei. A vaccine is not available and current treatment strategies and diagnostics are expensive and require appropriate medical infrastructure. Understanding how embryos specify asymmetric axes is a major focus of biology. The major hardware options as they pertain to practical use are addressed. The FAB score improved significantly after 12 weeks of treatment. Intensity of symptoms including mood and psychomotor activity has been shown to vary according to the time of the day in a group of depressed patients. When the heparin pentasaccharide is bound to antithrombin prior to incubation with thermolysin, it protects the N-terminal cleavage site, implying that segment 22-46 moves to interact with heparin in the conformational change and thus stabilizes the complex. Localization and efficacy analysis of the phototherapeutic lutetium texaphyrin (PCI-0123) in the murine EMT6 sarcoma model.

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International Commission on Radiological Protection (ICRP) Publication 103 provided a detailed explanation of the purpose and use of effective dose and equivalent dose to individual organs and tissues. A Kinematic Analysis of the Jumping Front-Leg Axe-Kick in Taekwondo. Primary hepatic neoplasms include hepatocellular carcinoma, intrahepatic cholangiocarcinoma, biliary cystadenocarcinoma, and a variety of mesenchymal tumors. In performance-optimized artificial neural networks, such as convolutional networks, each neuron makes excitatory connections with some of its targets and inhibitory connections with others. To assess whether HIV-protease inhibitors (ritonavir, indinavir, nelfinavir) impair the activity of the main enzymes involved in 1,25(OH) D homeostasis. We analyze the registered data of home parenteral nutrition (HPN) in our country during the year 2000. A 61-year old man moduretic 5 mg known with chronic atrial fibrillation was referred to our unit via the multidisciplinary team meeting, with severe mitral regurgitation secondary to prolapse of anterior mitral leaflet. It was confirmed that the biological character of the cancer cells derived from the reserve cells changed over the course of invasion.

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Tight junction biogenesis during blood-brain barrier development (BBB) in mesencephalon microvessels of mouse embryos of day 9, foetuses of day 15 and 19 depakote sprinkle 125 mg para que serve and new-born (2-day-old) mice was examined by light and electron microscopy, using monoclonal antibodies recognizing the tight junction peripheral membrane protein ZO-1. High Precision Spectral Calibration Method of Fourier Interferometric Spectrometer. Conditions for the generation of beta oscillations in the subthalamic nucleus-globus pallidus network. Usefulness of argyrophilic nucleolar organizer staining for histologic grading of soft-tissue sarcomas. Nine patients with known autosomal recessive polycystic kidney disease were examined with sonography and CT and screened for biochemical evidence of metabolic causes of nephrocalcinosis. Luciferase has been shown to be localized in these photocyte granules by the immunoferritin technique. To determine the contribution of the hemopoietic cell-restricted PI3K delta in neutrophil chemotaxis, we have developed a potent and selective PI3K delta inhibitor, IC87114. Some further studies will make more precis the epidemiological and genetical profile of ankylosing spondylitis in Togo. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. The increasing antimicrobial resistance has once again brought up the question of whether antibiotics are really needed in the treatment of acute otitis media.

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