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Femistra (Anastrozole)

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Femistra is a selective non-steroidal aromatase inhibitor. Aromatase is a protein in your body that produces estrogen, which can promote the growth of some cancer cells. By blocking aromatase, Femistra lowers the body's normal production of estrogen. Without estrogen, some breast cancer cells can't grow.

Other names for this medication:
Altraz, Altrol, Anabrez, Anastrocare, Anastrozole, Anatero, Anazol, Armilon, Armotraz, Femistra, Femitraz, Qubol, Redest, Rimidex, Stazonex, Xenosoul

Similar Products:
Periactin, Trileptal, Omnicef, Clomid, Nexium, Lipitor, Cleocin, Avelox, Inocid, Esivan, Infulid, Dianorm, Anreb, Itrole,

Also known as: Anastrozole


Femistra (anastrozole) lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Femistra is used to treat breast cancer in postmenopausal women.

Femistra is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).


The following information describes Femistra dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

Drug forms and strengths

Femistra comes as 1-mg tablets that are taken by mouth.

Dosage for breast cancer

The usual dosage of Femistra for breast cancer is one tablet taken once a day. It’s best to take your dose at the same time each day.

What if I miss a dose?

If you forget to take a dose of Femistra, take the missed dose as soon as you remember. However, if it’s almost time for your next dose, just skip the missed dose and take your next dose as usual. Don’t take two doses together to make up for a missed dose.

To help make sure that you don’t miss a dose, try setting a reminder on your phone. A medication timer may be useful, too.

Will I need to use this drug long term?

Femistra is meant to be used as a long-term treatment for breast cancer. If you and your doctor determine that Femistra is safe and effective for you, you’ll likely take it long term.

The length of time that you’ll take this drug depends on the type of cancer you’re using it to treat. Below we describe the typical length of time that Femistra is given. But to know for sure how long you should take Femistra, talk with your doctor.

For advanced breast cancer

If you’re taking Femistra to treat advanced breast cancer, you’ll usually take the drug for as long as your doctor feels this treatment is right for you. (With advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes, called locally advanced breast cancer, or spread to other parts of your body, called metastatic breast cancer.)

For early breast cancer

If you’re taking Femistra as adjuvant treatment of early breast cancer, you’ll usually take the drug for at least 5 years. Adjuvant treatment is used to lower the risk of your breast cancer coming back or spreading after it’s already been treated with surgery. (With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit.)

It’s not currently known if Femistra should be continued after these 5 years. And if so, it’s not known for how long after the first 5 years it should be taken.

Some studies found that breast cancer is less likely to come back if an aromatase inhibitor is taken for an additional 5 years after the first 5 years of adjuvant therapy. (Aromatase inhibitors are a class of medications.) With this approach to treatment, the drug would be taken for a total of 10 years. However, other studies didn’t show a benefit for extending the treatment beyond 5 the usual years.

In addition, one recent study found that taking Femistra for a total of 10 years didn’t provide any more benefit than taking it for a total of 7 years.

How long you take Femistra for early breast cancer will depend on how likely your breast cancer is to come back. It will also depend on your risk of side effects from treatment.


If you overdose Generic Femistra and you don't feel good you should visit your doctor or health care provider immediately.


Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Femistra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

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A pharmacological evaluation was performed with the human colorectal carcinoma cell line HCT116 and revealed that the anticancer activity of flavonols was higher when compared with that of the respective chalcone precursors. Thus, understanding the kinetics of CML and normal progenitor cells may lead to therapeutic strategies capable of reducing malignant cell growth and reactivating normal haemopoiesis. This decrease in one specific mitochondrial transcript may represent a novel mechanism for differential expression of mitochondrially-encoded genes. Species pertaining to the order Solemyida (subclass Opponobranchia) show many peculiar evolutionary adaptations, f.i. In experiments lasting 10 min, using animals that had been exposed to cadmium for 1 to 6 h, it was observed that the animals became significantly less positively phototactic after 4 h of exposure to 0.06 mg/L cadmium compared to control animals that had not been exposed to cadmium. Long term storage of extracted proteins showed that both total protein and protease activity were affected when they were stored as extracted protein. The effects of tryptophan at particular positions of CBMCenA on the binding and hydrolysis of polyester substrate were investigated by replacing each of Trp14, Trp50 and Trp68 with leucine or tyrosine, respectively. Cytochrome P-450 activity in malarial parasites and its possible relationship to chloroquine resistance. Tendon transfers and realignment osteotomies for treatment of stage II posterior tibial tendon dysfunction. Do anxiety and depression have a common pathophysiological mechanism?.

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Most of the clinical data supporting the need for microbicidal therapy and testing have focused on bacterial infections. Are the local blood oxygen level-dependent (BOLD) signals caused by neural stimulation response dependent on global BOLD signals induced by hypercapnia in the functional MR imaging experiment?. However, chronic GVHD is characterized by a relative deficiency of IL-2 and IFN-gamma producing cells compared with other patients post-bone marrow transplantation (BMT). Cpkk1, MAPKK of Cryphonectria parasitica, is necessary for virulence on chestnut. Galectin 3 is a beta-galactoside binding protein which localizes to the cytoplasm of proliferative, mature, and hypertrophic chondrocytes in the growth plate cartilage of developing long bones. To investigate the long-term clinical course of eyes with pseudodrusen appearance caused by subretinal drusenoid deposits. Furthermore, there was an association between the expression levels of MIR17HG and gastric cancer grades and stages. One of the variables in generating hematopoietic progenitor cells is that different labs use different approaches in generating progenitor cells. We also examined 2 factors that might predict these transitions: trauma exposure and alcohol involvement.

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Changes related to cognitive abilities, mobility, affect, vitality and somatic complaints. Most of the cases showed a loss of spiral ganglion cells, with various degrees of hair cell loss and atrophy of the stria vascularis. Comparative study of the calcium adenosine triphosphatase of basal membranes of human placental trophoblasts from normotensive and preeclamptic pregnant women. The gastric emptying system-through a Levin tube from the stomach is not usually sufficient to get off all the swallowed air. In contrast, the ED50 in moderate seizure GEPRs (GEPR-3s) is 25 mg/kg. Severe hyperbilirubinemia in a 10-year-old girl with a combined disorder of hereditary spherocytosis and Gilbert syndrome. Immunological profile of arsenic toxicity: a hint towards arsenic-induced carcinogenesis. Evaluation of ozonated oxygen in an experimental animal model of osteomyelitis as a further treatment option for skull-base osteomyelitis.

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Mild cognitive impairment: incidence and risk factors: results of the leipzig longitudinal study of the aged. Polymorphic light eruption is characterized by a recurrent cutaneous reaction to ultraviolet (UV) exposure occurring after a delay of several hours that consists of pruritic erythematous papules, vesicles, or plaques on usually only some exposed sites and resolves without scarring over about a week. The effect of smaller volume, thickened formulas on gastroesophageal reflux is not clear. Traditionally, the difference between pretest and posttest scores is used as an estimate of change. during the third phase, the whole luteal cell mass consists of thecal luteal cells and connective tissue elements as the granulosa luteal cells had degenerated and disappeared by this stage. Disruption of this normal microbial-host communication network has deleterious consequences for the host and is associated with intestinal pathologies such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC). The alanine substitution totally prevents the interdomain bridging interactions, while the aspartic acid substitution was expected to weaken these interactions.

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In the present study, we characterized learning and memory deficits in C57BL/6 mice infected with LP-BM5. It is not known when behavior problems begin in children with epilepsy. Migrated implants should be considered for removal in order to prevent possible sinusal diseases. With a focus on mental health teaching, mental health promotion and prevention, nursing has the potential for providing an essential, holistic, now missing, link in the delivery of mental health services. Here we show that the two molecules directly bind to each other in vitro and that binding sites on TN-R localize to two domains, the fibrinogen domain and the epidermal growth factor-like repeat domain with the N-terminal cysteine-rich stretch. An adult pig model of retrosternal adhesion formation via an inferior hemisternotomy was used to evaluate the formation and development of pericardial and retrosternal adhesions, as well as adhesion reduction using two thicknesses of a bioabsorbable polylactide film. In the brainstem and spinal cord, synaptic excitation and inhibition are mediated by the excitatory transmitter glutamate acting on ionotropic glutamate receptor-gated cationic channels and the inhibitory transmitter glycine acting on glycine receptor (GlyR)-gated chloride channels. Cystoscopy revealed a red sessiled tumor 5 mm in diameter on the right wall of the bladder. Once NAB have developed, the bioavailability of IFNbeta as measured by MxA is completely inhibited.

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We recruited consecutively adult patients with SIRS admitted to an intensive care unit. A Student-Led Health Education Initiative Addressing Health Disparities in a Chinatown Community. If mitochondrial dysfunction underlies the origins of metabolic disease then determining the precise molecular pathway will be essential for the development of new treatment and prevention strategies. Further analysis showed a larger amount and greater stability of the rpoS mRNA as well as a higher level of RpoS itself with the overexpression of CspC and CspE. It can be treated symptomatically and return to sport allowed when symptoms permit. These datasets afford the opportunity to identify a large numbers of patients across a broad spectrum of comorbidities, providing information regarding disparities in care and outcomes, preoperative risk stratification parameters for perioperative morbidity and mortality, and national epidemiologic rates and trends. Apoptosis of bovine granulosa cells after serum withdrawal is mediated by Fas antigen (CD95) and Fas ligand.

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Effect of infusion therapy on the functional state of the kidneys in burn shock. We anticipate that structural and genetic investigations on lens crystallin genes and their expression might provide a framework for revealing the basis of (some) hereditary disorders in the visual system. Mutant selection window in levofloxacin and moxifloxacin treatments of experimental pneumococcal pneumonia in a rabbit model of human therapy. Using newly developedCerS5knock-out mice, we show here thatCerS5is essential to maintain cellular C16:0sphingolipid pools in lung, spleen, muscle, liver, and white adipose tissue. Transthoracic echocardiogram revealed the nonspecific cardiac abnormalities of right ventricular dilation and septal flattening.

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A distance analysis of 180 different proteins and structure calculations using simulated data suggests that our method will allow the global folds of a wide variety of proteins to be determined. K-76 COOH did not have any significant effect on a delayed-type contact skin reaction in mice, or on experimental allergic encephalitis in guinea pigs. The objective of this report is to rapidly present the emergency committee as a whole andto describe in more detail the work that the CUMP accomplished during the 36 hours necessary to takecharge of the majority of the French passengers of the Costa Concordia. These findings underscore the potential of local gene-therapeutic interventions in preventing luminal narrowing at the outflow tract of hemodialysis grafts. We sought to compare the value of HCV universal screening versus risk-based selective screening in pregnant women. This study was undertaken to compare the outcomes of the Lecompte procedure and Rastelli repair in the transposition of the great arteries (TGA) with ventricular septal defect (VSD) and left ventricular outflow tract obstruction (LVOTO) and to determine the risk factors associated with unfavorable events. An attenuated form of the disease (AFAP) is associated with fewer polyps, but still a high risk for colorectal cancer. Idiopathic acute transverse myelitis in children: an analysis and discussion of MRI findings. Moisture and fat content, marbling level and color of boneless rib cut from Nellore steers varying in maturity and fatness.

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Optimization of selection for growth in Menz sheep while minimizing inbreeding depression in fitness traits. Moreover, Smad2 or Smad3 with Smad4 enhanced the proteolytic pathway of p57(Kip2). Control samples were obtained from 19 children who received lumbar punctures to rule out meningitis. Concentrations expressed as 2,3,7,8-TCDD equivalents (Nordic model) were in the order of 1-3 pg/g(-1) fat (0.2-1.6 pg ml(-1) milk) which is comparable with ringed and harp seal blubber from the same region. The extensive genetic diversity of human immunodeficiency virus type 1 (HIV-1) presents a significant barrier to the development of an effective and durable HIV vaccine. Others split off from the primary ependyma, but remained allegra dosage by weight in contact with it. Thyroid hormone values and urinary iodine excretion were determined before, as well as 1, 4 and 12 weeks after iodine contamination by coronary angiography.

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We also evaluated claudin-4 mRNA expression levels using quantitative real-time reverse transcription polymerase chain reaction (RT-PCR) and analyzed its specific promoter methylation status using quantitative methylation-specific PCR. Secondary acute lymphoblastic leukaemia in a multiple myeloma patient. Including this report, there have been 60 cases of trigeminal trophic syndrome reported from 1982 to 2002. ADP also lowered the K(m) for glutamine and increased V(max) and these effects were further enhanced by the presence of ATP. Results were compared to those of matched controls without complications. We show that 16q deletions are typically confined to immature anaplastic-blastic tumor elements, while deletions are absent in maturing tumor components. All were treated with emergent what is the generic form of zetia carotid stent placement and intra-arterial thrombolysis. To assess the consistency of the benefits of blood pressure lowering on secondary stroke risk by age, sex and geographic region of recruitment.

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Global silicate mineralogy of the Moon from the Diviner lunar radiometer. The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models. Determining host suitability of pecan for stored-product insects. By using this scheme, we construct Pb nanomesas on Si(111) substrates whose thickness can be controlled with atomic-layer precision. Herein, we demonstrate that inhibition of antibody production specific for myelin oligodendrocyte glycoprotein (MOG) and suppression of chronic EAE induced by MOG in susceptible mice can be elicited by MOG-Ig gene therapy. Hyperglycemic but not normoglycemic global ischemia induces marked early intraneuronal expression of beta-amyloid precursor protein. The effects of long-term administration of rubidium or lithium on reactivity to stress and on dopamine output in the nucleus accumbens in rats. To report a case of cervical stenosis repaired by hysteroscopic cervical shaving that created a smooth passage for ET in a patient undergoing IVF. In the subset of children who had a treated eye and a control eye that could be refracted, distributions of refractive errors in treated versus control eyes were similar at most ages. Not all individuals infected with HIV receive potent antiretroviral therapy, however, because of socioeconomic or other factors, and others will be intolerant of these drugs or experience drug failure.

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To investigate the morphological characteristics and expression of cell cycle regulatory proteins in cellular variants of idiopathic focal segmental glomerulosclerosis (FSGS). Both l-norephedrine (5-50 mg/kg) and d-norephedrine (5-150 mg/kg), administered intraperitoneally, significantly suppressed feeding after a 4-hr fast during the dark cycle. Lectin blotting identified a range of eight HPA-binding glycoprotein bands with molecular weights of 16-66 kD in Caco-2 cells, six glycoproteins of 16-36 kD, and three protein bands of 35, 24, and 21 kD in IEC- what dose of remeron causes weight gain 6 cells. Countries with longer length of stay for heart failure hospitalizations had significantly lower rates of readmission within 30 days of randomization. In vivo endoscopic Raman spectroscopy of human tissue using a fiber optic probe has been previously demonstrated. Surgical delay has the ability of enhancing survival and anti-infection of the rabbit reverse fascio-cutaneous flap.

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To determine statewide, population-based outcomes of persons hospitalized with traumatic brain injury (TBI) at 1 year postinjury. In addition, transgenic mice created with the prion protein promoter develop widespread neurologic disease, reminiscent of juvenile forms of other polyglutamine diseases. Ocular occlusion and monovision optical correction enable the patient to ignore the image from the misaligned eye. No evidence of space-time clustering of dates and places of onset was found for these cases. Although it is a nonrandomized retrospective chart review of a small cohort of patients with a relatively short follow-up period, PBI may be a better option than WBI following BCS in some young patients with breast cancer. This review will summarize the results obtained from various studies investigating the roles of O-glycans in immunological processes.

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We reviewed our experience in patients with hepatocellular carcinoma (HCC) and chronic hepatitis to determine if differences exist in preoperative status and postoperative survival between those with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Adverse events reported by postmenopausal women in controlled trials with raloxifene. We present the twentieth case in English literature of primary osteoclast like-giant cell tumor with accompanying low to intermediate grade salivary duct carcinoma of parotid gland, metastasizing to the ipsilateral cervical lymph node. In the open form, ACPT-I is only bound to lobe I through interactions with Lys74, Arg78, Ser159, and Thr182. In many instances, papers are published initially that suggest that a certain antibody or panel of antibodies is of value in the diagnosis of a particular neoplasm and in the distinction of this from mimics. Culturing of T cells from the preoperative period with autologous monocytes from the 2nd POD induced a decreased expression of their TCR zeta. Variability in different strains of Cladosporium herbarum with special attention to carbohydrates and contents of two important allergens (Ag-32 and Ag-54). Vasodilator therapy in patients with mild symptoms of heart failure may not only improve exercise performance, but also reduce mortality.

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Transendothelial channels in fenestrated endometrial blood capillaries of rats. In most cases they describe a single muscle arising from the duodeno-jejunal flexure and reaching the right side of the diaphragm oesophageal opening. Afterwards, the position of the maxilla was corrected in the same patients using the SSN. Sensitivity and specificity are shown to be comparable in both procedures. Our quest for a green, non-toxic and environmentally benign synthetic design for the fabrication of metal nanoparticles has led to the use of essential oil present in plant parts as the bioreductant. Randomized, double-blind comparison of ciprofloxacin and ampicillin. Photodynamic oxidation of Staphylococcus warneri membrane phospholipids: new insights based on lipidomics. The concentration of AP-2 in dorsomedial locations along the neuraxis suggests a regionally adalat 20 mg specific role for this transcription factor in the regulation of neuronal function. However, there is a need for further quantitative information that will lead to greater understanding of transduction mechanisms, impulse initiation, and intrafusal fiber contractile activation. Pilonidal sinus disease, characterised by communicating granulating natal cleft tracts and abscesses, is a common condition.

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