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Glucophage (Metformin)

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Glucophage also increases your body's response to insulin, a natural substance that controls the amount of glucose in the blood. Glucophage is used alone or with other medications, including insulin, to treat type 2 diabetes. Glucophage is in a class of drugs called biguanides.

Other names for this medication:
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Also known as: Metformin


Glucophage XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Glucophage XR is sometimes used together with insulin or other medications, but this medicine is not for treating type 1 diabetes.


Usual Adult Dose for Diabetes Type 2:

Immediate-release: Initial dose: 500 mg orally twice a day or 850 mg orally once a day Dose titration: Increase in 500 mg weekly increments or 850 mg every 2 weeks as tolerated Maintenance dose: 2000 mg daily in divided doses Maximum dose: 2550 mg/day Extended-release: Initial dose: 500 to 1000 mg orally once a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2500 mg daily Comments: -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. -Immediate-release: Take in divided doses 2 to 3 times a day with meals; titrate slowly to minimize gastrointestinal side effects. In general, significant responses are not observed with doses less than 1500 mg/day. -Extended-release: Take with the evening meal; if glycemic control is not achieved with 2000 mg once a day, may consider 1000 mg of extended-release product twice a day; if glycemic control is still not achieve, may switch to immediate-release product. Use: To improve glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise.

Usual Pediatric Dose for Diabetes Type 2:

10 years or older: Immediate-release: Initial dose: 500 mg orally twice a day Dose titration: Increase in 500 mg weekly increments as tolerated Maintenance dose: 2000 mg daily Maximum dose: 2000 mg daily Comments: Take in divided doses 2 to 3 times a day with meals. Titrate slowly to minimize gastrointestinal side effects. Safety and effectiveness of Glucophage extended-release has not been established in pediatric patients less than 18 years of age. Use: To improve glycemic control in children with type 2 diabetes mellitus as an adjunct to diet and exercise.

Detailed Glucophage dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can cause severe hypoglycemia or lactic acidosis.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Glucophage are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Glucophage if you are allergic to metformin, or if you have:

severe kidney disease; or metabolic acidosis or diabetic ketoacidosis (call your doctor for treatment).

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Glucophage. Be sure your caregivers know ahead of time that you are using this medication.

Tell your doctor if you have ever had:

kidney disease (your kidney function may need to be checked before you take this medicine); high ketone levels in your blood or urine; heart disease, congestive heart failure; liver disease; or if you also use insulin, or other oral diabetes medications.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Follow your doctor's instructions about using Glucophage if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. Tell your doctor if you become pregnant while taking Glucophage.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

You should not breastfeed while using this medicine.

Glucophage should not be given to a child younger than 10 years old. Glucophage XR is not approved for use by anyone younger than 18 years old.

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Mutagenicity analysis of water samples from Seydisuyu (Kirka, Turkey) stream under the influence of boron production complex. The results are of interest for the treatment of cognitive symptoms in BD patients, as persistent cognitive impairment may hamper full rehabilitation. Emergency medical service in RSFSR and the measures for its further improvement. In mouse fertilized egg PKB/Akt controls the cell cycle by changing the cell localization of p21. Long-term results with the SJM valve demonstrated a durable prosthetic valve, excellent long-term patient survival, and freedom from valve-related events followed reoperative open-heart valve replacement surgery. Will decision-support systems be widely used for the management of plant diseases?. The effect of some organic substances on the mycelium of the fungus Ustilago nuda (Jens.) Rostr. The therapeutic principle is a photochemical reaction of riboflavin and UVA light leading to free oxygen radicals in the corneal stroma that induce covalent linking of the collagen fibrils. Their dependency on the concentration of extracellular iodide was strikingly different.

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Measurement and sociological analysis of violence in French contemporary society. The Emergency Nurses Association (ENA) convened a Nurse Practitioner (NP) Validation Work Team and conducted a Delphi study to verify and gain consensus on professional and clinical competencies for NPs in emergency care. SLC consistently improved the quality of stallion sperm samples from a large number of ejaculates. The presence or absence of an allergy according to the standard protocol for electrodermal testing. Seasonal ozone response of mature beech trees (Fagus sylvatica) at high altitude in the Bavarian forest (Germany) in comparison with young beech grown in the field and in phytotrons. Captopril and L-arginine have a synergistic cardioprotective effect in ischemic-reperfusion injury in the isolated rat heart. Randomized, subject-masked, parallel-group, multicenter, 1-year study. Pulmonary neuroendocrine tumors are frequently encountered as small biopsy and resection specimens. Therefore, p27 can be an important tool in making therapeutic decisions. The majority of R genes from Solanaceae were grouped into 87 subfamilies, including 16 TIR-NBS-LRR (TNL) and 71 non-TNL subfamilies.

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Endothelial activation--a strategic event during postischemic myocardial inflammation. Chromobacterium violaceum is a Gram-negative bacterium found in a wide variety of tropical and subtropical ecosystems. No difference between acute and control animals was found in the heart for beta-HAD activity. (11)C-PET imaging reveals transport dynamics and sectorial plasticity of oak phloem after girdling. On the basis of the sparse literature on skin HPC and of our two cases, we suggest that not only the internal, but also the external nose should be considered a predilection site for HPC. Detailed analyses of the gut microbiome and its effect on human physiology and disease are emerging, thanks to advances in high-throughput DNA-sequencing technology and the burgeoning field of metagenomics. We find that three of the four redesigned proteins fold much faster than their naturally occurring counterparts. A discretised set of 3D coil windings is obtained using an equi-flux streamline seeding method. Male Wistar-H-rats were exposed monthly to a 60cobalt-source low dose whole body irradiation (0.25 Gy, total dose: 4.5 Gy). This study showed that natural product Icaritin (ICT) could increase the phosphorylation level of Phosphatidylinositol 3 kinase (PI3K) at p110 catalytic subunit and promote PI3K/Akt signaling markers in C2C12 cells.

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