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Nexium

Nexium is a proton pump inhibitor that is used to treat certain stomach and esophagus problems, such as acid reflux and ulcers. It works by lowering the amount of acid production in your stomach.

Other names for this medication:
Epraz, Esgred, Esodoc, Esofag, Esofine, Esomac, Esomeprazole, Esomper, Esoper, Esotrax, Ignis, Naksium, Neutraflux, Nexpro, Prazonid, Raciper, Ranidom, Sompraz

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Also known as: Esomeprazole

Description

Nexium (esomeprazole magnesium) is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Nexium is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions involving excessive stomach acid such as Zollinger-Ellison syndrome. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Nexium may also be given to prevent gastric ulcer caused by infection with Helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Nexium is not for immediate relief of heartburn symptoms.

Dosage

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Take this medicine at least 1 hour before a meal and for the full time of treatment, even if you begin to feel better after a few days.

If you are taking this medicine to treat an ulcer caused by an H. pylori infection, take it together with the antibiotics (eg, amoxicillin, clarithromycin) at the same time of day.

To use the capsule:

Swallow the capsule whole. Do not crush or chew it. If the capsule cannot be swallowed, open it and sprinkle the contents on one tablespoonful of applesauce. Swallow the mixture right away. Do not chew or crush the granules.

To use the capsule with a nasogastric (NG) tube:

Open the capsule and empty the granules into a 60 mL catheter-tipped syringe and mix it with 50 mL of water. Shake the syringe well for 15 seconds. Inject or pour the mixture into the nasogastric tube. Refill the syringe with a small amount of water and shake. Flush the tube to rinse all of the medicine into the stomach.

To use the oral suspension:

Empty the contents of a 2.5 mg or 5 mg packet into a container with 5 mL of water. Empty the contents of a 10 mg, 20 mg, or 40 mg packet into a container with 15 mL of water. Stir and leave it for 2 to 3 minutes to thicken. Stir well and drink within 30 minutes. If any medicine remains after drinking, add more water, stir, and drink immediately.

To use the oral suspension with a nasogastric or gastric tube:

Add 5 mL of water to a catheter-tipped syringe and add the contents of a 2.5 mg or 5 mg packet. Add 15 mL of water to a catheter-tipped syringe and add the contents of a 10 mg, 20 mg, or 40 mg packet. Shake the syringe right away and leave it for 2 to 3 minutes to thicken. Shake the syringe again and inject or pour the mixture into the tube within 30 minutes. Refill the syringe with 15 mL of water and shake. Flush the tube to rinse all of the medicine into the stomach.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (capsules or suspension): To prevent NSAID-associated gastric ulcer: Adults—20 or 40 milligrams (mg) once a day for up to 6 months. Your doctor may adjust your dose if as needed. Children—Use and dose must be determined by your doctor. To treat duodenal ulcers with H. pylori infection: Adults—40 milligrams (mg) once a day for 10 days. The dose is usually taken together with amoxicillin and clarithromycin. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. To treat erosive esophagitis: Adults—20 or 40 milligrams (mg) once a day for 4 to 8 weeks. Your doctor may adjust your dose as needed. To prevent erosive esophagitis from coming back, your doctor may want you to take 20 mg once a day for up to 6 months. Children 12 to 17 years of age—20 or 40 milligrams (mg) once a day for 4 to 8 weeks. Your doctor may adjust your dose as needed. Children 1 to 11 years of age and weighing 20 kilograms (kg) or more—10 or 20 mg once a day for 8 weeks. Your doctor may adjust your dose as needed. Children 1 to 11 years of age and weighing less than 20 kg—10 mg once a day for 8 weeks. Your doctor may adjust your dose as needed. Children 1 month to less than 1 year of age and weighing more than 7.5 kg to 12 kg—10 mg once a day for up to 6 weeks. Your doctor may adjust your dose as needed. Children 1 month to less than 1 year of age and weighing more than 5 kg to 7.5 kg—5 mg once a day for up to 6 weeks. Your doctor may adjust your dose as needed. Children 1 month to less than 1 year of age and weighing 3 kg to 5 kg—2.5 mg once a day for up to 6 weeks. Your doctor may adjust your dose as needed. Infants younger than 1 month of age—Use and dose must be determined by your doctor. To treat gastroesophageal reflux disease (GERD): Adults—20 milligrams (mg) once a day for 4 weeks. Your doctor may adjust your dose as needed. Children 12 to 17 years of age—20 milligrams (mg) once a day for 4 weeks. Your doctor may adjust your dose as needed. Children 1 to 11 years of age—10 milligrams (mg) once a day for up to 8 weeks. Your doctor may adjust your dose as needed. Children younger than 1 year of age—Use and dose must be determined by your doctor. To treat Zollinger-Ellison syndrome: Adults—40 milligrams (mg) 2 times a day. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor.

For oral dosage form (delayed-release 24 hour capsules): To treat heartburn: Adults—20 milligrams (mg) once a day for 14 days. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Nexium and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Nexium overdosage: nausea, feeling confusion, fast heartbeat, convulsions, dry mouth, flushing, blurred vision, short breathing, sweating, tremor, problems with coordination, dyspepsia, migraine, drowsy.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nexium dosage information

Side effects

The most common side effects associated with Nexium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Nexium if you are allergic to Generic Nexium components or to the other benzimidazole medicines (mebendazole (such as Vermox), albendazole (such as Albenza), omeprazole (such as Prilosec), lansoprazole (such as Prevacid), pantoprazole (such as Protonix) and to esomeprazole), rabeprazole (such as AcipHex). Do not take Generic Nexium if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Nexium can harm your baby. It can be used together with antibiotics. Be careful with Generic Nexium if you suffer from or have a history of liver disease. Be careful with Generic Nexium if you are taking such medicines as atazanavir (such as Reyataz); diazepam (such as Valium); a blood thinner (warfarin (such as Coumadin)); digoxin (such as Lanoxin, Lanoxicaps); iron (such as Feosol, Mol-Iron, Fergon, Femiron), ketoconazole (such as Nizoral). Do not stop taking Generic Nexium suddenly.

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Serum calcitonin measurement was performed before and after incubating each serum sample in heterophilic-blocking tubes (HBTs) and the differences were calculated. Adjuvant or neo-adjuvant radiotherapy (RTH) increases susceptibility to trauma and infections. Chinese herbs as immunomodulators and potential disease-modifying antirheumatic drugs in autoimmune disorders. Morphine synergizes with lipopolysaccharide in a chronic endotoxemia model. Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase. Prognostic factors indicating LTH in adults with sleep-disordered breathing.

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Serum TMCA levels were monitored and appear to be useful in predicting toxicities. Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli. Western blot analysis confirmed the results that PEBP protein levels increased significantly in plasma and liver tissues only in ALF mice, but not in surviving mice treated with GalN/LPS. The reduction in PN excitability is likely secondary to modulation of primary motor cortex or brainstem nuclei, and identifies a neuroanatomical pathway for the cerebellum to assist in coordination of upper limb muscle synergies in humans. A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity. Proximal EPSC diminish and become narrower with decreasing hyperpolarization or modest depolarization, distal EPSC increase and become wider, intermediately distant EPSC change insignificantly. This study illustrated that TAFI was affected by hyperglycaemia and confirmed that TAFI is involved in wound healing. Aneurysmal bone cyst masquerading as unknown mandibular metastatic deposit causing pathological fracture. The morphological characteristics of the aggregates strongly suggest that they represent accumulations of clathrin and possibly other proteins of the coat that are synthesized in large amounts prior to endocytic activity.

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Mediastinal lymph node metastasis of colon cancer: report of a case. One model for looking at experience-dependent plasticity is environmental enrichment (EE), where animals are exposed to a complex novel environment. Dietary fish intake and sleep quality: a population-based study. Here we demonstrate a supramolecular carpet with widely uniform interfacial structure and high adaptability on a metal surface via a one-step process. The pattern of relationship changed during the course of pubertal development with the strongest associations for pubertal children.

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Morbidity is the major issue that may guide treatment decisions. The most remarkable changes were seen in the region of a protein with an Rf of 0.25, an area with high sucrase and maltase maltase activity, and in the region of a protein with an Rf of 0.28, which was characterized by alkaline phosphatase activity. Observed temperature dependencies are consistent with a constant change in heat capacity, DeltaC degrees P, upon binding of the analyte to the stationary phase. The bleb reformed in each case and maintained its patency for a minimum follow-up of 6 months. Mn3O4-graphene hybrid as a high-capacity anode material for lithium ion batteries. Labelling of glutamine acid with 113mIn for scintigraphic examinations of liver and spleen. A smaller percentage of minority children had dental insurance coverage. Herein I examine large samples of values for circulating blood cell (hemocyte) concentration (CHC) among both wild-type and mutant Drosophila larvae, and demonstrate in both cases that the distribution of individual values does not conform to normality, but does conform to log-normality.

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Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis. Octylcyanoacrylate, a new-generation, medical-grade tissue adhesive, has been found to be an effective alternative to replace skin sutures on virtually all facial lacerations and has been employed in low-skin tension wound management. These are compared with fertility signals and sexually dimorphic profiles already described from O. In Sox8-deficient mice, oligodendrocyte development proceeded normally until birth. This paper describes 3D EFIT simulations of guided wave propagation in undamaged and damaged anisotropic and quasi-isotropic composite plates.

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The objective was to determine the value of clinical and analytical maternal factors to predict birth weight and umbilical cord biochemical markers of diabetic fetopathy. In general, the Langmuir model provided the best fit for the adsorption data. Angiogenin can induce endothelial cell migration, proliferation, tubulation, as well as inhibition of cellular apoptosis. To prospectively evaluate the effectiveness and safety of continuous wound infiltration (CWI) for pain management after open gastrectomy. A Literature Survey on Cost-Effectiveness of Proton Beam Therapy in the Management of Breast Cancer Patients. An interference with alphafetoprotein was proven explaining this electrophoretic aspect. A period of 30 min coronary artery occlusion followed by 3 h reperfusion resulted in an increase in both 111In and 125I counts in the area at risk (AR) of the myocardium. Recent studies have indeed shown that the hemodialysis procedure induces a net protein catabolic state at the whole-body level as well as in skeletal muscle. Fuc-TVI required the carbonylamino group at C-2 of GlcNAc for its acceptor recognition. Adequacy of immediate Lamivudine trial for chronic hepatitis B patients with acute exacerbation.

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Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. The finding of more severe periodontal conditions associated with VTM in these young adults indicates that third molars may have a negative impact on periodontal health. Right-sided precordial leads (V4R, V5R and V6R) were routinely added to standard 12-lead electrocardiogram (ECG) on all patients presenting with acute coronary syndrome at the Tygerberg cardiac unit for a 7-month period. Treatment of mixed atrial fibrillation and typical atrial flutter by hybrid catheter ablation. A total of 212 patients who had undergone ALND for invasive breast cancer had arm volume measurements preoperatively, and at intervals postoperatively. The antioxidant defences can be induced either by respiratory growth or in the presence of pro-oxidants.

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Double E-box motif is required for peroxisome proliferator-activated receptor-gamma-dependent activation. Despite their importance in clinical settings, the selective forces responsible for the evolution and maintenance of integrons are poorly understood. Although exogenous prostaglandin E2 increased lipopolysaccharide-induced NF-kappaB activity and cyclooxygenase-2 transcription in vascular-associated elements, it significantly reduced microglial activation and tumor necrosis factor-alpha expression in the brain parenchyma. It is deduced from the clinical findings and the history in each case that this infection was imported, and favoured by the geographical location of the city and prior mutilating gastrointestinal surgery. The measuring tape was blank and the place of the first measurement was marked as performed in clinical practice. The patient in case 1 is a 77-year-old woman with bilateral open-angle glaucoma who had been treated with latanoprost and timolol for 11 months. Spirillum swimming: theory and observations of propulsion by the flagellar bundle. Child Health, Maternal Marital and Socioeconomic Factors, and Maternal Health. Only a small minority of trauma victims develops post-traumatic stress disorder (PTSD), suggesting that victims vary in their predispositions to the PTSD response to stressors. Interestingly, isoform C/EBPepsilon p30 but not p32 was differentially upregulated in NB-4 promyelocytic leukemia cells treated with retinoids.

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This shift of balance of anti- and pro-apoptotic proteins was found to control caspase-3 activity which, in turn, downregulated Bcl-Xl expression in PMN undergoing apoptosis. Mbagathi District Hospital outpatient department between 1st January to 30th June 2012. Evaluation of the electrocardiographic criteria for left ventricular hypertrophy. Kinetics of liberation of the theophylline in semi-solid matrix based of Gelucire. A catch-up study of former child and adolescent psychiatric inpatients: psychiatric status in adulthood.

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Combining clinical probability and D-dimer with a single ultrasound in the diagnostic workup of patients with possible deep vein thrombosis is highly cost-effective, allowing a reduction in costs and resource use without any substantial increase in mortality. Fertilization outcomes were related to follicular fluid concentrations of 17beta-oestradiol, progesterone, follicle stimulating hormone, luteinizing hormone (LH), growth hormone (GH), prolactin (PRL), interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF alpha). We therefore tested whether the mindfulness trait predicted a reduction of grammatically congruent preferences, and used emotional primes to explore the influence of affect. Influence of sampling frequency and amplitude resolution of the ECG side effects of prilosec medication signal was tested. A novel autoantibody from a rabbit preimmune serum that immunostains myelinated nerves of the brain. Recent advances in protein detection and analysis have lead to multiple in depth studies that analyze the adipose-derived stem cell (ASC) secretome. Many people have asymptomatic herniations, and today supersensitive diagnostic imaging is widely available. The implications of this research are discussed in terms of several intervention strategies. Leisure time sport activities and maximal aerobic power during late adolescence. The patterns of pathologic changes and stages of cortical abnormalities were studied by histology and immunocytochemistry methods.

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Affected individuals showed abnormal N- and mucin-type O-glycosylation, and mass spectrometry indicated reduced incorporation of galactose and sialic acid, as seen in other Golgi homeostasis defects. Wnt/LRP5, a new regulation osteoblastic pathway involved in reaching peak bone masses. The statistical evaluation resulted in a highly epivir hbv cost significantly better fit when the data were analyzed according to the two-compartment model. Because of its inhibitory activity on interferon-gamma production, we further investigated the effects of indirubin on 2,4, 6-trinitro-l-chlorobenzene (TNCB)-induced delayed-type hypersensitivity as a representative inflammatory reaction. The autonomic nervous system is known to control and regulate all involuntary physiologic activities by controlling the activities of the internal organs, glands, and circulation. Fat is harvested during machine-assisted liposuction in tumescent local anesthesia with microcannulas, processed in a special open manner, and reinjected through a 24-gauge needle for intra- and subdermal augmentation. Significant regional group differences were found in all four parametric comparisons.

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Clozapine upregulates the expression of the vesicular GABA transporter (VGAT) in rat frontal cortex. Gene-targeted mice studies revealed that ovalbumin-induced ADAM8 was largely dependent upon signal transducer and activator of transcription (STAT) 6 and the IL-4 receptor alpha-chain. A rapid and robust particle-enhanced turbidimetric immunoassay for serum beta 2 microglobulin. Knowledge of the exact amino terminus albenza dosing pinworm was necessary before accurate expression of active enzyme could be attempted. We develop, to the best of our knowledge, the first model for an array waveguide grating (AWG) device subject to quantum inputs and analyze its basic transformation functionalities for single-photon states.

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Both of these diseases are characterised by chronic antigen expression in the setting of focal or global deficits in the immune system that hamper the generation of protective immunity. We also gained information on viral responses to changing environments, a valuable piece of information in extending our understanding of the viruses in the environment. The contractile response to phenylephrine of aortic rings obtained from pancreatectomized rats was not affected by melatonin. Surf scoters show a behavioural flexibility in response to currents, alternately using compensation and drift as the movement goal and consequent cost of accuracy change. We found variable myocyte labeling with TUNEL in the failing myocardium of patients with CHF and only obtained scarce additional immunohistochemical evidence for myocyte apoptosis with immunostaining for active caspase 3 and caspase 3 and no positive myocytes with immunostaining for cleaved actin or PARP fragments. TUNEL-positive cells were found in the epithelia of the pterygial head, but not in the body of pterygia and normal conjunctiva. Its clinical application is now wider than that of a stethoscope in the intensive care unit where the noise level is high. In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity.

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Future research should determine which strategies are most effective. The significance of these results in relation to autoimmunity is discussed. Recent reports suggest the efficacy of adjunctive pharmacotherapies and combining pharmacotherapy with behavioral therapy to improve treatment response. Prolactin pretreatment increased the radiosteroid uptake only in the liver. Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process.

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Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes. The purpose of this study was to compare long-term clinical and radiographic outcomes of mobile- (MB) and fixed-bearing (FB) total knee arthroplasties (TKA). p27kip1 (cyclin-dependent kinase inhibitor 1B) controls ovarian development by suppressing follicle endowment and activation and promoting follicle atresia in mice. Several studies have been conducted on the tick-borne encephalitis virus and on the Sindbis virus in which microRNA precursors were artificially incorporated and demonstrated the production of mature microRNAs. Although the nocturnal penile tumescence (NPT) test is considered the gold standard for the differential diagnosis of psychogenic versus organic erectile dysfunction (ED), concerns have recently been raised regarding the financial and time expenditure it demands. NF-IL-6 and NF-kappaB are expressed in macrophages and is induced by bacterial lipopolysaccharides. These results suggest that protein phosphorylation and/or nuclear export participate in the post-translational regulation of UDG1A protein levels.

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