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Notence (Alprazolam)

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Notence is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Notence, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Notence is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alcicalm, Aldep, Alpanol, Alpose, Alpraday, Alprasan, Alprazan, Alzin, Alzocum, Alzot, Ansilumirm, Anxigo, Censir, Cqlam, Depwell, Endolam, Esteem, Fluti, Jolistar, Meloprax, Pacyl, Parazolam, Plaxid, Prazil, Pronext, Resta, Sanprazole, Somnirest, Tenlax, Tenolam, Tensfree, Tranisol, Trapose, Tryzo, Zolar, Zopax

Similar Products:
Cardura, Dostinex, Zetia, Celexa, Prandin, Effexor, Risperdal, Lodine, Sydom, Amarkor, Cezcold, Domsin, Ekaril, Megapress, Voxidep, Lozitan,

Also known as: Alprazolam


Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.


Take Notence XR exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Notence XR may be habit-forming and should be used only by the person it was prescribed for. Notence XR should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Do not crush, chew, or break a Notence extended-release tablet. Swallow the tablet whole. It is specially made to release alprazolam slowly in the body. Breaking the tablet would cause too much alprazolam to be released at one time.

Contact your doctor if this medicine seems to stop working as well in treating your panic or anxiety symptoms.

Your symptoms may return when you stop using Notence XR after using it over a long period of time. You may also have seizures or withdrawal symptoms when you stop using Notence XR.

Withdrawal symptoms may include blurred vision, trouble concentrating, loss of appetite, diarrhea, muscle twitching, numbness or tingling, or increased sensations.

Do not stop using Notence XR suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. Do not miss any scheduled visits to your doctor.

Store Notence XR at room temperature away from moisture, heat, and light. Remove any cotton from the bottle of disintegrating tablets, and keep the bottle tightly closed.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

Detailed Notence XR dosage information


If you have been prescribed Notence for medical reasons, the best way to avoid a Notence overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Notence consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Notence XR dosage information

Side effects

The most common side effects associated with Notence are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Notence if:

you also take itraconazole or ketoconazole (antifungal medicines); or you have a history of allergic reaction to any benzodiazepine (alprazolam, diazepam, lorazepam, Ativan, Klonopin, Restoril, Tranxene, Valium, Versed, and others).

To make sure Notence is safe for you, tell your doctor if you have ever had:

breathing problems such as COPD (chronic obstructive pulmonary disease) or sleep apnea (breathing that stops during sleep); drug or alcohol addiction; depression, mood problems, or suicidal thoughts or behavior; or kidney or liver disease (especially alcoholic liver disease).

Tell your doctor if you are pregnant or plan to become pregnant. Alprazolam may harm an unborn baby. Avoid taking this medicine during the first trimester of pregnancy.

If you use Notence while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks.

You should not breastfeed while using alprazolam.

Notence is not approved for use by anyone younger than 18 years old.

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To identify potential sources of selection bias created by subjects lost to follow-up in studies of traumatic brain injury (TBI). The present method of three-dimensional tracking has the potential to detect and characterize a range of clinically significant functional deficits. Continuously activated T cells from one patient with SLE displayed increased amounts of soluble Fas that inhibits anti-Fas mediated cell death. The clinicopathologic features of two squamous odontogenic tumors are presented. (1) Effect of oral administration of lysozyme on serum lysozyme activity. Orbital floor fractures and diplopia, Experiences and results in ophthalmologic and surgical treatment. To examine the effects of an intervention comprising (1) a practice-based care coordination program, (2) augmented by pay for performance (P4P) for meeting quality targets, and (3) complemented by a third-party disease management on quality of care and resource use for older adults with diabetes. Morphological pattern of childhood solid tumours in Lagos University Teaching Hospital.

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A comparison of the proteome pattern of Solanum tuberosum suspension cultures cv. Iron, silver, and zinc concentrations in fish liver also increased in urban areas. Data were collected using non-participant observation and a computerised event recorder. Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice. Efficacy was evaluated by means of the following scales: Tremor Scale (TS), Global Disability Examiner Scale (GDE) and Global Disability Patient Scale (GDP). The aim of this study was to evaluate the antihypertensive effect and the safety of an ARB and a very low dose of HCTZ in hypertensive patients. Given that elevated ROS correlates with Wolbachia-mediated antiviral protection, we also investigated the involvement of ERK in antiviral protection in flies infected by Wolbachia.

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Clinical picture of secondary tumorous lesions of the heart in lung cancer and other malignant neoplasms. A Biomarker Panel Increases the Diagnostic Performance for Epithelial Ovarian Cancer Type I and II in Young Women. To correlate the immunohistochemically detected loss of E-cadherin expression with patient age, clinical and biological variables, and to investigate the prognostic value of these variables for the relapse-free and overall survival of patients with different stages of newly diagnosed prostate cancer. All patients were treated with radical surgical debridement and a combination of antibiotics. Superoxide dismutases are essential for the survival of all oxygen metabolizing organisms. Diseases affecting the coronary microvasculature will affect vasodilator-induced changes in coronary flow by inhibiting changes in myocardial blood volume. At 2 weeks the immunoreactivity was mainly located along the cytoplasmic apical border in both the caput and the cauda epididymidis.

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Safe and effective vaginally applied microbicides could help to control the continuing spread of sexually transmitted diseases. OGL was applied to 79 pregnant women at gestational age between 24 and 28 weeks. One year later, white matter studies indicated both reduced N-acetylaspartate and elevated myoinositol. The motion reverse correlation (MRC) method: a linear systems approach in the motion domain. The addition of a prophylactic knee brace significantly reduced the level of impact force at the point of impact, but this did not result in a significant reduction of anterior cruciate ligament elongation for any test.

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The hypothesis underlying the study was that after 6 months of HCDE the total energy intake would be increased by 627 kJ from baseline (primary endpoint). A case-control study on working conditions and the risk of colon and rectal cancer was performed in southeastern Sweden during 1984-86. Evaluation of a drug prevention program for young high risk students. Sulfate incorporation was significantly inhibited in cell cultures subjected to the 0.5, 0.25, or 0.05 Hz cyclic loads for 1.5 h, but stimulated in explant cultures with a 0.5 Hz cyclic 1.5-h load. Decrease in thyroid hormones results in fall in body temperature. Hypo-responsiveness to growth factors is a fundamental feature of cellular senescence. Results suggest the protective role of active oxygen species in Cu IUD users which lasts for a brief period. We report the results of optimized immunogold-labeled cryosection electron microscopy of HSV-1-infected cultured human fibroblasts (MRC-5).

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The devices is used to study the membrane processes of small cells not able to be penetrated with the traditional two microelectrode system. The objective of this study was to investigate how the degree of amine substitution of amine-modified poly(vinyl alcohol) (PVA) affects complexation of siRNA, protection of siRNA against degrading enzymes, intracellular uptake and gene silencing. As a rare cause of spontaneous EDH, dural metastasis from malignancy should be considered. We first demonstrate that a 187-bp domain (-424 to -237 bp) behaves as a negative region when placed upstream either of the NF-kappa B binding site of vimentin or of a heterologous enhancer such as that present in the desmin gene promoter. During treatment of cells with cisplatin, covalent complexes of TrxR1 with either Trx1 or TRP14 (Trx-related protein of 14kDa) were formed, as verified by Western blot analyses and mass spectrometry. Although vasopressin concentrations were not as high as those measured during some other clinical situations, these data suggest that a relative vasopressin deficiency is not a direct cause of hypotension during OLT. Vitamin D analogues have been used successfully to reduce PTH levels, but increases in serum calcium, phosphorus, and calcium x phosphorus ion product levels may occur. Crystallization and preliminary X-ray crystallographic studies of phosphopantetheine adenylyltransferase from Helicobacter pylori. The authors contrasted the use and outcomes of DNR orders for nationally representative samples of Medicare patients hospitalized with specific diagnoses in 1981 to 1982 and 1985 to 1986. A very rare cause of a deglutition disorder: achalasia of the cricopharyngeal muscle.

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The temporal pattern of exposure to glucocorticoids has been reported to be a critical factor in determining the outcome of glucocorticoid actions at the brain. It was confirmed that there is a unique profile of cancelation of surgery problem for every institute, an extension of infrastructure may not be the only solution. Molecular evolution and phylogeny of dengue type 4 virus in the Caribbean. Escherichia coli O157:H7 causes bloody diarrhea and potentially fatal systemic sequelae in humans. In this study, global DNA methylation levels were assessed by the Infinium HumanMethylation450 BeadChip Array on 18 ACC tumors and 6 normal adrenal tissues. Results indicate that fumonisin B1 toxicity may involve secretion of TNF-alpha by TNF-alpha-producing cells without altering interleukin-1alpha or interferon-gamma. We postulate that such a mechanism may be important in the immunopathogenesis of HCV infections.

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The Strengths and Difficulties Questionnaire (SDQ)--further evidence for its reliability and validity in a community sample of Dutch children and adolescents. The goal of this project was therefore to build a more ergodynamic microscope which minimizes the light exposure to the tissue. Optimization of the post-injury time to fly using serum cytokine and biomarker levels may reduce the potential secondary cerebral injury induced by aeromedical evacuation. An approach to simulate and visualize intraoperative scattered radiation exposure to improve radiation protection training. Laparoscopic Assisted Surgical Staging (LASS) for Endometrial Cancer. Because S100A4 was not localized in the nucleus of MC3T3-E1 cells and AS clones, it is unlikely that S100A4 directly regulates the expression of these genes.

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Here we have studied CD95 expression and susceptibility to CD95-mediated apoptosis in peripheral blood mononuclear cells (PBMC) and activated T cells of 20 healthy individuals and 20 MS patients, half of whom were HLA-DR2-positive. Emergence of a powerful connection between sensory and cognitive functions across the adult life span: a new window to the study of cognitive aging?. A plasmid containing approximately 1 kb of the CYP3A4 regulatory region (which contains several recognised regulatory elements including glucocorticoid responsive elements) coupled to the reporter gene for human secreted placental alkaline phosphatase (SPAP) was transfected into the human hepatoblastoma cell line HepG2. Rats were injected with placebo or baclofen (20 micromol/kg subcutaneously) once daily for 14 days. PET provides a tool with which to evaluate the processes that contribute to pulmonary dysfunction in neonates. Hemolytic properties of various serological types of proteus in the Ivan-Franko region. An electrocardiogram with manual calculation of the QT interval should be performed on all patients with a suggestive history.

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Finally, we note that even relatively simple models of heterogeneous membranes are able to reproduce many of the properties of much more complex biological membranes. A new technique of mechanical support for microinstruments of action (e.g., scissors and air turbine drills) is presented. Here we show that calpeptin inhibits tyrosine phosphatases, enhancing tyrosine phosphorylation particularly of paxillin. Eruptive dermatofibromas in AIDS patients: a form of mycobacteriosis?. Follow-up was continued until both the sixth nerve palsy and the ear infection had resolved. Bronchografic, angiopneumographic and spirometric findings in a groupof children operatedon for left lung exeresis after bronchiectasis. Chronic pacing in the infarct region did not alter the primary end point of LV remodeling over 1 year. Thus, enzyme sensitivity could not be related to the type of cutter or the distance between cutting sites. Gender stereotypes hold that males outperform females in mathematics and spatial tests, and females outperform males on verbal tests.

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The height of intervertebral space (HIS), cervical alignment (CA), segmental angle (SA), and Visual Analogue Scale (VAS) were compared between the groups, preoperatively, postoperatively, and at final follow-up. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells. Familial atrial myxomas may present as a component of the Carney complex, an autosomal dominant multiple neoplasia and lentiginosis syndrome. Their conspicuous clinical features frequently allow preoperative diagnosis of hypophysitis. Impaired function of the intestinal barrier in a novel sub-health rat model. The outputs of the classifer exhibit some interesting patterns that appear to be related to the chemical composition of the gallstones contained in these images.

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The manner in which the CNS deals with interaction torques at each joint in ball throwing was investigated by instructing subjects to throw a ball at three different speeds, using two (elbow and wrist) or three joints (shoulder, elbow, and wrist). A method for addressing research gaps in HTA, developed whilst evaluating robotic-assisted surgery: a proposal. Similarity of the Raman spectra of CPTs with corresponding FT-Raman spectra in the near-infrared allowed the latter to be compared with their SERS counterparts in order to analyse the interaction of the drugs with silver colloids. Cyto-architectonic characteristics of the ganglion urispas drug class isthmi and its displacement in the brain stem in frog and in certain reptiles. Consequently, while a noncognate tRNA may be recognized by GlnRS, the resulting tRNA-enzyme complex displays a considerably reduced affinity for glutamine compared to wild-type. Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum. cholerae non-01 in these two respects, then the potential for epidemics in the United States is real.

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A method for obtaining repeatable measurements of the tensile properties of skin at low strain. This corneal viability was compared with the maximal modified average score published in the report of ECETOC. Testing for non-random mating: evidence for ancestry-related assortative zyprexa zydis wafer 5 mg mating in the Framingham heart study. Compact and light-weight automated semen analysis platform using lensfree on-chip microscopy. No significant differences were observed between the bending, torsional and tensile application. A special device simplifies the technique of establishing the horizontal reference for reproducing the occlusal plane. Preterm infants had significantly lower ceruloplasmin concentrations in cord blood than term infants, the mean level in the preterm infants being 0.07 g/l.

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Each chart is evaluated by a single reviewer with the use of worksheets with explicit, objective criteria that represent practice guidelines. Cyclic adenosine monophosphate (cAMP) agonists reverse and prevent I/R-induced microvascular leak, but reversal by inhaled NO (INO) has not been tested. Functional Gene Markers for Fumarate-Adding and Dearomatizing Key Enzymes in Anaerobic Aromatic Hydrocarbon Degradation in Terrestrial Environments. In contrast, IL-6 and IL-1 receptor antagonist (IL-1ra) were the most abundant cytokines in the PF and plasma, and the concentrations of IL-4 and IL-10 were also elevated in both compartments. The blood plasma level was 3 ng/g, and those of lung, kidney, liver, and brain were 12, 2.5, 1.0, and 0.5 ng/g, respectively. Determination of the dynamic viscosity of transparent fluids by using dynamic light scattering. Spectrographic comparison of ranges of vibration frequency among some innocent cardiac murmurs in childhood and some murmurs of valvular insufficiency. RA/AA treated collagen gene expression followed a similar trend. Cholelithin therapy of angiocholecystites and dyskinesias of bile ducts in children.

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Point mutations in the K-ras gene are frequently observed in a variety of human malignancies, including colorectal and pancreatic cancers. Extracts of untreated tumors, which had grown for a further 96 h, were also studied. Dying of nostalgia: homesickness in the Union Army during the Civil War. Criminal thought process as a dynamic risk factor: Variable- and person-oriented approaches to recidivism prediction. The SFE values and SFE characteristics were not influenced by the type of resin composite, but were influenced by the type of adhesive system. As part of the analysis, a technique is outlined for identifying boundaries between regions where polymorphisms occur and regions where the alleles under consideration go either to fixation or extinction. Under steady-state conditions, the resulting echoes have very complex T1 and T2 relationships.

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Glycogen in somatic muscle ant the myocardium of pregnant rabbits after glucagon administration. This rapidly induced gene encodes an enzyme that associates with the proteasome and increases its proteolytic activity. The principal phenolic and alcoholic components of wine protect human lymphocytes against hydrogen peroxide- and ionizing radiation-induced DNA damage in vitro. Platelet aggregation in patients with chronic renal insufficiency not under dialytic treatment. Middle theolair 250 mg hond latency auditory-evoked potentials in myotonic dystrophy: relation to the size of the CTG trinucleotide repeat and intelligent quotient.

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Interaction of rifampicin and isoniazid with large unilamellar liposomes: spectroscopic location studies. Telepathology with an integrated services digital network--a new tool for image transfer in surgical pathology: a preliminary report. It appears that the kappa-opioid PD117302, but not the NSAID naproxen, inhibits the upregulation of ICAM-1 in arthritic joints, suggesting these agents act via different mechanisms. SF-6D scores were estimated from the NDI, neck and arm pain scores were estimated using a linear regression model. Using several chimeras generated systematically in the N terminus, a 10-residue motif near the M1 region was identified in which only three amino acids are different between Kir2.3 and Kir2.1. Blind predictions indicate that the KIX domain is a putative three-helix bundle, although the chirality of the bundle could not be uniquely plavix drug classification anticoagulant determined.

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