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Skelaxin (Metaxalone)
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Skelaxin

Skelaxin is a muscle relaxant, but experts aren't exactly sure how it works, since it doesn't work directly on the muscles. They believe it relieves pain by relaxing the nerves causing your muscles to tighten or cramp up.

Other names for this medication:
Fenaplus, Flexura, Metadol, Metaxalone, Mobiswift, Skeltab

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Furadantin, Trileptal, Differin, Levothroid, Ticlid, Allegra, Arava, Kamagra, Xalatan, Benemid, Bandhan, Ciplin, Ziana, Mefnor, Xepalat, Vistaril,

Also known as: Metaxalone

Description

Skelaxin (metaxalone) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain.

Skelaxin is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

Dosage

Usual Adult Dose for Muscle Spasm:

800 mg orally 3 to 4 times a day.

Usual Pediatric Dose for Muscle Spasm:

>= 12 years: 800 mg orally 3 to 4 times a day.

Detailed Skelaxin dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of metaxalone can be fatal.

Storage

Keep out of the reach of children. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Skelaxin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Skelaxin if you are allergic to metaxalone, or if you have:

anemia (low red blood cells); severe kidney disease; or severe liver disease.

To make sure Skelaxin is safe for you, tell your doctor if you have liver or kidney disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether metaxalone passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Skelaxin is not approved for use by anyone younger than 12 years old.

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Reconstruction of MRI data encoded with arbitrarily shaped, curvilinear, nonbijective magnetic fields. Images of mandibular interdental alveolar bone in the premolar and molar regions were obtained using micro-CT and compact CT. Shoots of a soil- or sand-grown dwarf bean variety were exposed to O(3) concentrations in the range of 500 to 900 ppb for up to 5 h. This implies that some tumor cells can escape the immune defenses of the normal immunocompetent host by mechanisms other than loss of tumor-specific transplantation and Class I major histocompatibility antigens. Pilot test of an organizational culture model in a medical setting. Thickness and type of ceramic as well as extrinsic colorants, glazing, and a luting agent affect the color coordinates of monochromatic industrial ceramic. Male gender and age were the strongest predictive factors for low bone mass.

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Regulation of succinate dehydrogenase: does the membrane environment change the catalytic activity of the enzyme?. Older patients, patients with organ system failure and patients with co-morbid conditions were at high risk of developing nosocomial infections. An interesting case of indeterminate leprosy developing at the site of dog bite is being reported. Bone bruises on magnetic resonance imaging (MRI) are common in patients with acute knee ligament injuries and have been well described for injuries involving the anterior and posterior cruciate ligaments and the medial collateral ligament. The intervention was designed using an evidence-based approach to effective implementation.

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The MLR is a clinically relevant in vitro assay where lymphocytes from one individual (effector, E) are incubated with the lymphocytes of another individual (stimulator, S) which have been previously rendered incapable of blast transformation by gamma-irradiation. Alcohol misuse in South african male adolescents: a qualitative investigation. To determine the effect of early administration of high-dose intravenous corticosteroids on duration of emergency room treatment and hospital admission rate in patients with acute asthma. Exclusion criteria were traumatic strictures, panurethral strictures, lichen sclerosus, and failed hypospadias repair. The results indicated that the extract obtained by dry saponification has the highest contents of octacosanol and triacontanol among extracts by all used extraction methods including dry saponification, saponification in alcohol, saponification in water (neutralized and non-neutralized), and transesterification. The findings in end-to-end repairs distracted at 8 weeks and those of grafted nerves at 12 weeks were comparable to those in distracted normal nerves. Information on coffee consumption and occupation was re-coded following standard criteria. Using in situ FTIR spectroscopy, ZIF-8 framework was investigated when loaded with CO2 in a diamond anvil cell at high pressures far beyond the conventional gas adsorption pressure. In order to gain further insight into the evolution of novelty and diversity, we describe a simple computational model of gene regulation that controls the development of locomotive multicellular organisms through a fixed set of simple structural genes. Endotoxin damages platelets and leukocytes, both of which can form prostaglandins and could be the source of a dilator prostaglandin.

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Herein we have reported primary graft dysfunction early posttransplantation due to cast nephropathy, associated with thrombotic microangiopathy. It seems that C in Iran is higher than that in developed countries, possibly because of its social structure. However, by applying differential gene expression analysis the sensitivity and predictability of the test may be increased. In slightly over one-third, the microtic ears were associated with marked horizontal and vertical asymmetries. Most patients treated at home by ECPs appeared satisfied and compliant with the care provided, according to the measures used in this study. The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization by neoplastic cells for new membrane biogenesis. Effects of newer oral contraceptives on the inhibition of coagulation and fibrinolysis in relation to dosage and type of steroid. Contrary to this longstanding recommendation, in our experience we have observed that there is no such skip area. The 90-day risk of stroke after a transient ischemic attack has been estimated to be approximately 10 percent, with one half of strokes occurring within the first two days of the attack. As representative RTK family-members the epidermal growth factor receptor (EGFR) and the c-Met receptor were studied.

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In the circulation, the IGFs bind to IGF-binding proteins (IGFBPs), which determine their bioavailability and regulate the interaction between the IGFs and IGF-1R. Lidocaine use for pain management during paediatric dental rehabilitation under general anaesthesia. Twenty-four rats were randomized into four groups: (1) sham-operated controls, (2) dobutamine group--subjected to abdominal hypertension and peritonitis-induced sepsis using cecal ligation and puncture (CLP), then treated with 10 microg x kg(-1) min(-1) intravenous (IV) dobutamine infusion, (3) levosimendan group--as in 2, then treated with levosimendan IV bolus 200 microg x kg(-1) followed by 200 microg x kq(-1) min(-1) IV infusion, and (4) a control group as in 2, with no treatment. In the Asia Pacific Cohort Studies Collaboration, total cholesterol (TC), high density lipoprotein cholesterol (HDLC) and triglycerides (TG) were measured for 333,297, 71,777 and 84,015 participants, respectively. These findings raise the possibility that PCa could soon transition from being a poorly understood, heterogeneous disease with a variable clinical course to being a collection of homogenous subtypes identifiable by molecular criteria, associated with distinct risk profiles, and perhaps amenable to specific management strategies or targeted therapies. Such an approach incorporates the advantages of both methodologies at the same time. Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing. The nature of protein-sorbitol-water interaction in solution at the molecular level, has been investigated using molecular dynamics simulations. The expression of IL-6 mRNA decreased 10 h after restimulation of P.

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Treatment of NAGS deficiency with N-carbamyglutamate, a stable analog of NAG, can restore deficient urea cycle function and normalize blood ammonia in affected patients. Plastic surgery in congenital anomalies: abnormalities of hands and feet. It remains to be determined whether propranolol also attenuates the expression of hypertrophy-associated foetal genes. Hospital admission rates for obesity and related comorbid conditions have increased more than four-fold over the past decade amongst children and young people. To simplify procedures to generate T cell lines, we used a CD4 peptide library for T cell stimulation instead of ill-defined viral lysates, without the requirement of dendritic cells. The advantages of these constructs over the conventional vectors presently used to express foreign genes in insect cell systems and their utilization in the production of virus insecticides are discussed. To perform a qualitative systematic overview of the measurement properties of the most commonly utilized walk tests in the cardiorespiratory domain: the 2-min walk test (2MWT), 6-min walk test (6MWT), 12-min walk test (12MWT), self-paced walk test (SPWT), and shuttle walk test (SWT). Novel antitumor artemisinin derivatives targeting G1 phase of the cell cycle. ACS releases guidelines on nutrition and physical activity during and after cancer treatment.

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We retrospectively reviewed the excretory urograms and CT scans of 32 patients (29 men and three women, 35-76 years old) with transitional cell carcinoma of the bladder who underwent orthotopic neobladder reconstruction with anastomosis to the native urethra after cystectomy. The complex care of the organ donor during preparation for organ removal and provision of the best organs for transplantation is often the responsibility of the organ procurement coordinator. CD4 cell lines were infected with laboratory cyclophosphamide adverse drug reactions strains and peripheral blood mononuclear cells were infected with primary isolates for evaluation of the anti-HIV effects. A laser-scanning confocal fluorescence microscope (LSCFM) was used to track the intravenously injected rhodamine-labeled MFLs within this cortical area, through the cranial window. These results establish the basis to understand and implement a more personalised approach for the interpretation of PSA blood levels in the context of PCa screening and diagnosis.

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Sesquiterpenoids and tirucallane triterpenoids from the roots of Scorzonera divaricata. In the human endometrium, we have recently reported that IL-15 messenger ribonucleic acid (mRNA) levels significantly increased during the secretory phase compared with those during the proliferative phase. Combination chemotherapy with drugs that target different viral proteins might be more effective than monotherapy. Childless families of RCT carriers have possibility to have healthy offsprings. Trauma can result in the severing of the dental pulp vessels, leading to hypoxia and ultimately to pulp necrosis. The relationship between dysfunctional voiding and congenital vesicoureteral reflux. Preclinical and clinical studies using different formats of BsAbs are described in this review using PubMed as a literature search tool.

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Properties of glutamine release from muscle and its importance for the immune system. The effect of diverting colostomy on anastomotic healing after resection of left colon obstruction. The existence of anti-neutrophil cytoplasm antibodies is helpful for differentiation and timely therapy of rapid progressive glomerulonephritis and the pulmonary renal syndrome. The more hydrophilic dyes such as TPPS2o (tetraphenylporphine disulfonates with the sulfonates groups cleocin dose on opposite rings), TPPS3 (tetraphenylporphine trisulfoantes), TPPS4 (tetraphenylporphine tetrasulfonates), A1PCS3 (aluminium phthalocyanine trisulfonates) and A1PCS4 (aluminium phthalocyanine tetrasulfonates) localized mainly extracellularly in the tumorous stroma. Clinical aspects of the relationship between oral contraceptives and abnormalities of the hemostatic system: relation to the development of cardiovascular disease. Staphylococcus aureus and Escherichia coli in nham (Thai-style fermented pork sausage). The advantages of using a Tenckhoff tube in continuous ambulatory peritoneal dialysis. Retinal and choroidal morphology was observed in animals of comparable age.

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