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Tofranil (Imipramine)
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Tofranil

Tofranil, synthetic drug used in the treatment of depression and enuresis (bed-wetting). Tofranil was the first tricyclic antidepressant. Introduced into medicine in the late 1950s, Tofranil was the first tricyclic antidepressant, a class named for its three-ring molecular structure.

Other names for this medication:
Alzoset, Antidep, Anxidep, Anxitab, Anxofit, Depforte, Depnil, Deprid, Depsan, Depsodep, Depsol, Diamin, Diazariv, Eldep, Estidep, Imilor, Imodep, Imprim, Imprin, Karthin, Libomin, Nimipose, Normadep, Toframine, Trydep

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Also known as: Imipramine

Description

Imipramine is used to treat depression. It belongs to a group of medicines known as tricyclic antidepressants (TCA). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.

Imipramine tablets are also used to treat enuresis (bedwetting) in children.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain imipramine. It may not be specific to Tofranil-PM. Please read with care.

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For depression: Adults—At first, 75 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day, unless you are in the hospital. Some hospitalized patients may need higher doses. Teenagers and older adults—At first, 25 to 50 mg per day using the tablets. Your doctor may adjust your dose as needed and switch you to the capsule form. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): For depression: Adults—At first, 75 milligrams (mg) per day. Your doctor may adjust your dose as needed. However the dose is usually not more than 200 mg per day. Some hospitalized patients may need higher doses. Teenagers and older adults—30 to 40 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 100 mg per day. Children—Use and dose must be determined by your doctor. For enuresis (bedwetting): Children 6 years of age and older—At first, 25 milligrams (mg) once a day, taken 1 hour before bedtime. Your doctor may adjust the dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of Tofranil can be fatal.

Overdose symptoms may include irregular heartbeats, feeling like you might pass out, seizures, or coma.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tofranil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Tofranil if you are allergic to Generic Tofranil components. Be very careful with Generic Tofranil if you are pregnant, planning to become pregnant, or are breast-feeding. Do not take Generic Tofranil if you are recovering from a recent heart attack or take MAO inhibitors, such as the antidepressants Nardil and Parnate. Be very careful with Generic Tofranil if you have diabetes, hypoglycemia, a history of mental disorders. Be very careful with Generic Tofranil if you are taking albuterol (Proventil, Ventolin), antidepressants that act on serotonin, including Prozac, Paxil and Zoloft, antipsychotic drugs such as Mellaril and chlorpromazine, barbiturates such as Nembutal and Seconal, blood pressure medications such as Catapres, Carbamazepine (Tegretol), cimetidine (Tagamet), decongestants such as Sudafed, drugs that control spasms, such as Cogentin, Epinephrine (EpiPen), Flecainide (Tambocor), Guanethidine, Methylphenidate (Ritalin), Norepinephrine, other antidepressants such as Elavil and Pamelor, Phenytoin (Dilantin), Propafenone (Rythmol), Quinidine, thyroid medications such as Synthroid, tranquilizers and sleep aids such as Halcion, Xanax, and Valium. Avoid alcohol. Do not participate in any activities that require full alertness if you are unsure about your ability. Try to stay out of the sun as much as possible. It can be dangerous to stop Generic Tofranil taking suddenly.

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Disagreement Between the Structure of the dTpT Thymine Pair Determined by NMR and Molecular Dynamics Simulations Using Amber 14 Force Fields. These data provide a novel mechanism of action of this small molecule with the potential for use in TRAIL-resistant tumors. However, these complex settings are hard to recapitulate in vitro. This article presents an analysis of current management strategies for cocaine abuse and dependence. The percentage of children vaccinated at each place was calculated overall and by age, race/ethnicity, income, and Metropolitan Statistical Area (MSA). This chapter reviews a few studies on shiftwork in countries of Asia and South America. Differences in affinity of anti-CD4 monoclonal antibodies predict their effects on syncytium induction by human immunodeficiency virus. Solution hybridization with probes specific for MT-I or MT-II mRNA established that these genes were co-induced in each of the organs and that the liver and kidney contained the highest absolute levels of these mRNAs, whereas in the intestine and spleen they were 10-20-fold lower. There have been few studies investigating the risk factors for bulimia nervosa (BN), and most have been in Anglo-Saxon countries. To determine the elements taken into account by French general practitioners to establish the initial diagnosis of benign prostatic hyperplasia (BPH) and to estimate the prevalence of BPH.

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Rat Nav1.2, Nav1.4, or Nav1.5 alpha subunits heterologously expressed in Chinese hamster ovary cells were analyzed by whole cell voltage clamp recording. To investigate the effects of non-drug interventions on the sleep quality of patients after mechanical cardiac valve implantation. Urticaria and parasites: case report and general view over the most common pathogens of chronic urticaria. It is suggested to be used along with routine treatment of RLS in hemodialysis patients. Steroid hormone formation in vitro by human ovarian follicles with different structures. Imbalance between production and scavenging of superoxide anion results in hypertension by the inactivation of nitric oxide, and the increased oxidative stress from the resultant peroxynitrite that is produced promotes inflammatory processes such as atherosclerosis. The potential mechanisms and clinical implications of our observations are discussed. After 4 weeks of treatment, complete resolution was observed in three cases, and substantial improvement was achieved in the other three patients.

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Simultaneous nitrification and denitrification in a novel membrane bioelectrochemical reactor with low membrane fouling tendency. The six electrodes were produced by spark cutting from a large antimony single crystal. The patients developed PKAS between 2 and 11 days after surgery. Preoperative pancreatic function appears to significantly influence long-term body weight after pylorus-preserving pancreatoduodenectomy. Mutated epigenetic modifiers, including DNMT3A, IDH1/2 and TET2, can be targeted by small molecule inhibitors, hypomethylating agents and histone deacetylase inhibitors. Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection. Avian influenza is a contagious disease of birds widely spread in wild fowl (namely ducks) and most feared in domestic birds, which may be infected with the highly pathogenic strains of the virus (HPAI). The genetic basis of NOA related to partial deletions of the Y-chromosome has been intensely investigated. The studied series of natural materials (spruce wood, pine bark, cork, peat, fusinite, lignite, oxidised lignite, bituminous coal and anthracite) was extended to include industrial carbon-rich materials: coke, activated carbon F-400 and Multisorb 100.

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The test battery consists of four different modules addressing different prosodic cues, namely duration, question vs statement, sentence stress, and speaker gender. The distribution of the mutations in the spatial structure of the ribosome showed a strong bias, with the strongly deleterious mutations being mainly localized at the interface of the large subunit and the mild ones on the solvent side. Effect of vitamin A and iron supplementation on hemoglobin and serum vitamin A level in pregnancy. Its use should therefore be restricted to selected low risk patients only. The voltammetric behavior of bone marrow of leukaemia and its clinical application. Partner support may be an important and potentially modifiable target for interventions to improve pregnancy outcomes. Prevalence of the APOC3 promoter polymorphisms T-455C and C-482T in Asian-Indians. The kinase suppressor of Ras (KSR) is a loss-of-function allele that suppresses the rough eye phenotype of activated Ras in Drosophila and the multivulval phenotype of activated Ras in Caenorhabditis elegans. Because of its role in carcinogenesis, apoptosis, and angiogenesis, it is an excellent target for developing new drugs with selectivity for prevention and/or treatment of human cancers. Several enkephalin-containing proteins with molecular weights between 8,000 and 20,000 daltons were purified from the bovine adrenal medulla.

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Interpretation three-dimensional visualization introduces an advantage in preoperative planning for corrective osteotomy of 3D femoral deformity, and the custom-made osteotomy guide is crucial to realize such a deliberate plan during the actual procedures. No differences were seen between rats receiving CDD alone and rats receiving CDD plus losartan with regard to the biochemical, morphological or molecular alterations induced by the CDD. We report two cases of toxic epidermal necrolysis related to the misuse of griseofulvin. Muscular coordination of knee motion during the terminal-swing phase of normal gait. Using a candidate approach for genes involved in planar cell polarity (PCP) signaling, we identified Drosophila Abl (dAbl) as a modulator of Frizzled(Fz)/PCP signaling. niger of ulstrasonic and glutaraldehyde using quantitative suspenion germicidal tests and simulated on-the-spot tests. injection of 10 mug/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. Intruder gonadectomy and elicitation of territorial aggression in the rat. The present study evaluated the relationship between mean county and state altitude in the United States and total age-adjusted suicide rates, firearm-related suicide rates, and non-firearm-related suicide rates. Cochrane Central Register of Controlled Trials and MEDLINE from inception to 1 July 2015 was searched.

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Characteristics, epidemiology, pathophysiology, diagnostic considerations, and appropriate testing options for myasthenia gravis (MG) are included. Three outcome measures are assessed in this paper: the SF-36, a generic measure of well being and functioning, the ALS Functional Rating Scale and the Carer Strain Index. For most people, fiber is probably harmless and it may do some good. An experimental, pre-intervention postintervention control group design was used in this study. Use of body mass index and body mass index growth charts for assessment of childhood weight status in the United States: a systematic review. Losses from lysimeters treated with inorganic fertiliser were 1.1 and 3.3 kg NO(3)(-)-N ha(-1) year(-1) in runoff and 31 and 79 kg NO(3)(-)-N ha(-1) year(-1) in tile-drainage. These data suggest that the higher number of infected house bees, the higher risk of transmission to queens. Posterior approach white line advancement ptosis repair: the evolving posterior approach to ptosis surgery.

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The following intraclass correlations for height and weight were found. Infections in the chicken embryo have been used to study the development of drug resistance in an embryo adapted strain of E. The research evidence has revealed several factors that can affect guideline uptake, and a variety of strategies that can facilitate implementation. The contrast maximum of bone marrow and soft tissue, best detectable in STIR- and T2-weighted spin echo images, occurred in the 1st-2nd week. Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells. Wild exhibits nonspecific binding with ssRNA/ssDNA fragments under electrostatic conditions and showed annealing and displacement of RNA strands in comparison to mutant. Pericardial adipose tissue is a visceral depot that promotes metabolic and cardiovascular adaptations. Three-dimensional-optical coherence tomography imaging of chronic thromboembolic pulmonary hypertension. We have found that the filum terminale (FT), a previously unexplored, expendable, and easily accessible tissue at the caudal end of the spinal cord, is a source of multipotent cells in postnatal rats and humans. Mutations in either the ETFA, ETFB, and ETFDH genes can cause MADD but very little is known about disease specific mechanisms due to a paucity of animal models.

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Suppressor activity varied among sites and followed a distribution curve that was displaced towards low suppression when resorption sites calcitriol drug classification were compared to healthy embryonic implants. Medical records of all the deceased patients between the 8(th) of February 1998 and 28(th) of February 1999 were reviewed. Mortality, repeat revascularization, myocardial infarction, and stent thrombosis. The photoexcited and adsorbed azo dye on the capillary surface of a PLCF induces uniform and highly ordered orientation of the liquid crystal (LC). Accumulating evidence reveals that bisphosphonate therapy has a significant effect in preventing skeletal complications in multiple myeloma, breast cancers, and prostate cancer, and in reducing skeletal complications in other metastatic bone malignancies.

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The general pattern of proteins synthesized from 14C-labeled amino acids during derepression was not significantly different in the presence or absence of rhizobitoxine. Relatively high titres (1/32-1/128) IgE responses were provoked by administration of OVA, while BSA stimulated only low titres (1/2-1/4) IgE. A 9-year-old female donkey, belonging to the unique and endangered indigenous breed of donkey in Portugal, was diagnosed with a sialolith in the rostral portion of the right parotid duct based on clinical, oral, dental, and radiographic examination results. In addition, we will concentrate on those aspects of the STEM which apply to biological uses, and we will therefore ignore the more esoteric applications, such as convergent beam diffraction patterns. The findings emphasise the importance of refined delineation of both clinical and pathological phenotype in furthering understanding of FTLD and its molecular substrate. Total of 3668 children of whom 2212 were well nourished and 1456 were malnourished.

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Kinetics of a cellular nitric oxide/cGMP/phosphodiesterase-5 pathway. Thus, for subjects at risk of lung carcinoma who could be followed by annual chest X-rays, sputum cytology did not improve survival, but for high risk subjects who had only a single screening examination, sputum cytology increased the number of early lung carcinomas detected. Oligonucleotides (ODNs) of 25 nucleotide length and complementary to genomic sequence subsuming the rd1 point mutation in the gene encoding the beta-subunit of minipress medication dosage rod photoreceptor cGMP-phosphodiesterase (beta-PDE), were synthesized with a wild type nucleotide base at the rd1 point mutation position. Prospective, randomized, controlled, intention-to-treat design comparing prophylaxis with fluconazole versus placebo for the first 28 days of life. An overview is provided here on the use of transgenic technology for the functional analysis of plant genes in model plants and a link made to their utilization in transgenic crops. Experiments on male rats showed enterally administered tetracycline and chlortetracycline to promote an elevation of the blood sugar level.

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The disease among most patients who died having a galactose elimination capacity greater than 13 mumol ran a subacute course. Theropod dinosaurs attained the largest body sizes among terrestrial predators, and were also unique in being exclusively bipedal. However, mitochondrial GSH controls hepatocyte susceptibility to TNF through modulation of reactive oxygen species, without inactivation of NF-kappaB-dependent survival pathways. Other case reports are reviewed and the anaesthetic management of patients with mediastinal tumours is discussed. The findings suggest a number of countermeasures for future on-orbit missions, some of which may not be relevant for expeditionary missions (e.g., to Mars). Renal function under the effect of ethambutol treatment of patients with destructive pulmonary tuberculosis. Ventricular remodeling of the native heart after heterotopic heart transplantation.

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By examining the expression of marker genes in RNAi embryos, we show that Tc-kni is required only for the formation of the posterior parts of the antennal and mandibular segments (i.e. Limits of Molecular Dithienylethene Switches Caused by Ferrocenyl Substitution. A review of the scientific literature on pesticide residues in freshwater and marine zooplankton indicates that despite the great number of pesticides in current use, only residues of the persistent organochlorine insecticides, many of which have been restricted or removed from general use in North America, have been determined. Some sesquiterpene lactones were recently demonstrated to inhibit inducible nitric oxide synthase (iNOS)-dependent nitric oxide (NO) synthesis. Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis. Upon incubation of LDL (0.1 mg of protein/ml) with purified, reconstituted rabbit P450 2E1 in the presence of NADPH and the NADPH-cytochrome P450 reductase, time- and P450 2E1 concentration-dependent LDL oxidation was observed, as analyzed by determining the formation of peroxides, thiobarbituric acid reactive substances (TBARS), and conjugated dienes. Abnormally reduced dorsomedial prefrontal cortical activity and effective connectivity with is bystolic generic yet amygdala in response to negative emotional faces in postpartum depression.

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A new imaging technique for the diagnosis of vesicoureteral reflux. The acknowledgment of the genetic component in the majority of pathologies, not only hereditary or oncological, and of the individual biological responses to therapies and in infectious diseases, is now granted. Hepatocyte growth factor preserves graft-versus-leukemia effect and T-cell reconstitution after marrow transplantation. In addition, the M1 subunit was found to be localized as a halo around isolated rat liver nuclei. Atomic insight into the CD4 binding-induced conformational changes in HIV-1 gp120. Septic arthritis of the hip must be managed promptly to avoid the serious complications associated with the condition. In this new photometric assay fecal samples are pretreated with detergent and high concentrations of salts. Spectroscopic and microcalorimetric studies on the molecular binding of food colorant acid red 27 with deoxyribonucleic acid.

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The PAAC produced cardiac hypertrophy by increasing LVW/BW, LVWT, LV protein content, LV collagen content and mean CSA of cardiomyocytes. Milk urea-nitrogen negatively affected first-service breeding success in commercial dairy cows in Prince Edward Island, Canada. This paper examined a number of leadership theories and established that Transformational Leadership is often cited as an appropriate leadership model for nursing. This effect seems to be due to bacterial toxins and not related with microbial pathogenicity. Par-4 exerts growth inhibitory effects on breast cancer cells and chemosensitizes them to docetaxel. These circuits are amiloride 5 mg tablet functionally dominated by partly closed limbic (regulating misery-fleeing behaviour) and extrapyramidal (regulating reward-seeking behaviour) cortico-striato-thalamo-cortical (CSTC) circuits. As a second objective, we evaluated whether Delta(9)-THC-tolerant rats were more vulnerable to morphine in a self-administration paradigm. The secretory proprotein convertase (PC) family comprises nine members: PC1/3, PC2, furin, PC4, PC5/6, PACE4, PC7, SKI-1/S1P, and PCSK9. mAb 9-OE immunoreactivity, unlike mAbs 5-OE and 13-OE, was restricted to only the axons and terminations of the primary sensory olfactory neurons in the frog nervous system. Combination of mood stabilizers with quetiapine for treatment of acute bipolar disorder: an open label study.

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This hypothesis is significant as such short loops can fold quickly and so would not be bound by the Leventhal paradox, giving insight into the possible nature of the funnel in protein folding. Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response. Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. Here we present a detailed compilation of practical methods for implementing these techniques with emphasis in their analytical or micropreparative applications. Annotation of these genes provided comprehensive information regarding the sex differentiation of flowers, including the signaling system, hormone biosynthesis and regulation, transcription regulation and ubiquitin-mediated proteolysis. hsa-miR-339-5p play important role in the regulation of lung cancer and it may be potential to be used as biomarker to predict lung cancer progression. In spite of technical advances in diagnostic radiology the recognition of a perinephric abscess is still a challenge to even the most experienced urologist. Forty-three anterolateral thigh flap procedures were performed over a 2-year period. Postmortem lung and kidney biopsies were taken for semiquantitative analysis of intravascular fat.

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Transition from pediatric to adult health care is fraught with difficulties. A quality assurance system ensured that computer-generated dosimetry matched film dosimetry in all cases. They were selected in five European countries: Belgium, Denmark, Greece, Sweden and the UK, and seen for psychological testing and a paediatric examination when they were 5 years old. Based on a new target-triggered aptamer molecular machine, a label-free and non-enzymatic target recycling amplification strategy for sensitive fluorescence detection of ATP in human serums is described. The two proteins that are derived from the N-terminal 87 kd region of the viral polyprotein are a 35 kd protein and HC-Pro (52 kd). Tuberous Sclerosis Complex (TSC) is a multiorgan disorder caused by a defect in the mTOR (mechanistic/mammalian target of rapamycin) pathway. The tremendous proliferation of new programs in allied health education is contrasted with the situation which existed in the pre-Flexner era of medical education. Excellent local disease control was achieved by using combined surgery and adjuvant hormonal therapy in patients with positive lymph nodes. Both assessments included the symptoms of the patients and the coping strategies, burden, distress and levels of EE of the relatives.

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The need to upskill rural general practitioners in mental health care. Nasal polyposis, a rare disease in childhood, can present itself as an idiopathic disease. Increased inhibitor of differentiation 4 (id4) expression in glioblastoma: a tissue microarray study. Several growth factors and cytokines have been implicated, with primary roles suggested for transforming growth factor-beta, connective tissue growth factor, angiotensin II and endothelin-1. Demographic implications of recent and prospective trends in old age mortality. Prevalence and dissemination of Salmonella serotypes along the slaughtering process in Brazilian small poultry slaughterhouses. However, further research (to identify whether genetic disposition or social and environmental circumstances are involved) is required. Predictors of psychosocial adjustment in patients newly diagnosed with gynecological cancer. After the incorporation of the sludges into the soil, increased bacterial counts were noted and substantial hydrocarbon elimination was achieved in 30 days, showing that bioremediation may be a possible technology for cleaning soils polluted with these sludges. they do not change their spatial field patterns or lasing frequencies.

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