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Zocor (Simvastatin)
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Zocor

Zocor is a lipid-lowering medication. It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth.

Other names for this medication:
Actalipid, Docsimvasta, Dosavastatin, Lipex, Lipinorm, Lodales, Normotherin, Simbastatin, Simgal, Simvastatin, Simvastatina, Simvastatinum, Simvofix, Sinvacor, Sivastin, Statinal, Vasilip, Zocord, Zorced, Zorstat, Zosta, Zostin, Zostine, Zovast, Zovastin, Zovatin, Zurocid

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Also known as: Simvastatin

Description

Zocor is an HMG-CoA reductase inhibitor. Zocor is used to: reduce the risk of heart attack, stroke, and death due to coronary heart disease; reduce the risk of heart attack, stroke, blood vessel blockage, or chest pain caused by angina; low high cholesterol and triglycerides; increase high-density lipoprotein (HDL, "good") cholesterol levels. Zocor is also known as Imvastatin, Simlup, Simcardis, Ranzolont, Simvador. Zocor works by reducing the production of certain fatty substances in the body, including cholesterol. Generic name of Zocor is Simvastatin. Brand name of Zocor is Zocor.

Dosage

Take Zocor exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Zocor is usually taken at bedtime or with an evening meal. If you take this medicine more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using Zocor, you may need frequent blood tests at your doctor's office.

You may need to take Zocor on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Zocor is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

Detailed Zocor dosage information

Overdose

If you overdose Zocor and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Zocor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Zocor if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with Zocor. These drugs should not be used while you are taking Zocor:

cyclosporine; danazol; gemfibrozil; nefazodone; an antibiotic - clarithromycin, erythromycin, telithromycin; antifungal medication - itraconazole, ketoconazole, posaconazole, voriconazole; hepatitis C medications - boceprevir, telaprevir; or HIV/AIDS medication - atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Zocor, tell your doctor if you are already using any of these other medicines:

lomitapide; or heart medication - amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure Zocor is safe for you, tell your doctor if you have:

history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily.

Zocor can cause a condition that results in the breakdown of skeletal muscle tissue, potentially leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take Zocor if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Zocor.

Zocor pregnancy and breastfeeding warnings (more detail)

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Sex ratio of transsexuals in Germany: the development over three decades. An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki-Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. However, the relationship between quantitative serum and qualitative urine levels of TCA-related compounds and their metabolites has not been comprehensively studied. We reviewed the experimental and clinical considerations of this strategy and we presented its problems and limitations. It is highly appealing to develop sensitive and accurate methods to detect deletions from sequencing data, especially deletions with microhomology and deletions with microinsertion. The 7 and 10-year actuarial progression-free survival (PFS), cancer-specific survival (CSS), overall survival (OS), potency, and continence rates were recorded.

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The evidence from randomised trials does not show significant benefit from azathioprine, interferon beta-1a or methotrexate but none of the trials was large enough to rule out small or moderate benefit. Autocrine and paracrine growth regulation of breast cancer: clinical implications. Hemoglobin Vancouver is a new abnormal hemoglobin with an amino acid substitution of the normal aspartyl residue 73 of the beta chain by a tyrosyl residue. Results from the present study showed that HFD in mice induces obesogenic changes, including increased numbers of ghrelin precursor-expressing cells and increased affinity of ghrelin-reactive IgG. We find that in response to proteasome inhibition, CHOP enhances the expression of a collection of genes encoding transcription regulators, including ATF5, which is preferentially translated during eIF2 phosphorylation. We hypothesized that ifosfamide and concomitantly applied mesna could have an influence on the flow properties of blood, and thus carried out an in vitro study. Furthermore, VIL2 is required for the maintenance of trimethylated histone H3 Lys-27 at MAF5 through the physical association with a component of polycomb repression complex 2. They reported few problems with customers and the majority of pharmacists would participate again. Recent insights on the medicinal chemistry of metal-based compounds: hints for the successful drug design. The p53 tumor suppressor protein is a biologically very important molecule.

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Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus are the most common secondary invaders. Characterization of the 175-kilodalton erythrocyte binding antigen of Plasmodium falciparum. Anxiety can lead to psychological stress, which has been shown to influence HIV disease progression. The difference between injuries on the right and the left is questionable and probably not as significant as previously thought. Taken together, we suggest that CTM alleviates repression by CE2, which allows HSF to be heat-inducibly phosphorylated and presume that phosphorylation is a prerequisite for the activator function of HSF when it binds to an atypical HSE.

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The present study was designed to assess the effect of matrine, an active component of Chinese traditional medicine, on angiotensin II (Ang II)-induced hyperplastic growth of cardiac fibroblasts in vitro. These results show that the presence of markings at the center of a flower are not so important as the presence of markings that will direct bees there. This study investigated eight new hepatitis C virus infections among patients treated at an outpatient hemodialysis facility. This new approach thus provides a potentially more cost-effective, label-free enzyme screening technique. Pharmacokinetics and clinical studies of norfloxacin in the pediatric field. Even though steroids are well known to be effective on managing AIA and its nasal polyps, histochemical examinations after steroid therapy and at recurrence, involving eosinophil infiltration of nasal polyps, have been less studied. The absorbance data of the kinetic assays are fitted by non-linear regression coupled to the numeric integration of the related differential equation. Early Vasospasm after Aneurysmal Subarachnoid Hemorrhage Predicts the Occurrence and Severity of Symptomatic Vasospasm and Delayed Cerebral Ischemia.

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In vitro activities of several antimicrobial agents against recently isolated and genotyped Chlamydia trachomatis urogenital serovars D through K. The inability to extinguish these associations is a key factor contributing to relapse. Effects of long- and short-term exposure to carbaryl on survival, growth and reproduction of Daphnia ambigua. Reorientional dynamics of water molecules in anionic hydration shells. Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by homozygous mutations of the survival motor neuron gene 1 (SMN1). Some standards and concepts were tested with building materials. Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit day. Pain and discomfort levels were compared between active and nonactive phases of the device. Hence, the STI genes from different human sources are highly conserved though mutagenesis still occurs. Two days after the first-stage surgery locoregional transarterial targeting chemoimmunotherapy was given.

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To examine the sensory effects of extreme sodium depletion in humans, 10 normal volunteers were fed a very-low-sodium diet and were treated with diuretics for 10 d. To investigate the association between single nucleotide polymorphisms (SNPs) in the adiponectin-encoding gene ADIPOQ and changes in serum lipid levels in HIV-1-infected patients after antiretroviral therapy (ART). Stability analysis of time-delay neural networks subject to stochastic perturbations. Thermoregulation and body fluids: role of blood volume and central venous pressure. The results of this study may well have relevance to indigenous communities in other countries that are faced with high levels of STI and substance abuse. Males in all age-groups (except in those aged 15-29 years) and females aged 0 to 4 years had higher drowning death rates than the average rate. All of the present findings suggest that cytoplasmic protein, nonstructure-bound or structure-forming, might be present in intact cells which could form microtrabecular structures when specimens are fixed by chemical fixatives without any extractions. Inflammation promotes oral squamous carcinoma immune evasion via induced programmed death ligand-1 surface expression. Studies of macrophage biology have been significantly advanced by the availability of cell lines such as RAW264.7 cells.

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